121 research outputs found
Oculomotor interference during manual response preparation: evidence from the response-cueing paradigm
Preparation provided by visual location cues is known to speed up behavior. However, the role of concurrent saccades in response to visual cues remains unclear. In this study, participants performed a spatial precueing task by pressing one of four response keys with one of four fingers (two of each hand) while eye movements were monitored. Prior to the stimulus, we presented a neutral cue (baseline), a hand cue (corresponding to left vs. right positions), or a finger cue (corresponding to inner vs. outer positions). Participants either remained fixated on a central fixation point or moved their eyes freely. The results demonstrated that saccades during the cueing interval altered the pattern of cueing effects. Finger cueing trials in which saccades were spatially incompatible (vs. compatible) with the subsequently required manual response exhibited slower manual RTs. We propose that interference between saccades and manual responses affects manual motor preparation
An evaluation of scanpath-comparison and machine-learning classification algorithms used to study the dynamics of analogy making
Sensorimotor supremacy: Investigating conscious and unconscious vision by masked priming
According to the sensorimotor supremacy hypothesis, conscious perception draws on
motor action. In the present report, we will sketch two lines of potential
development in the field of masking research based on the sensorimotor supremacy
hypothesis. In the first part of the report, evidence is reviewed that masked,
invisible stimuli can affect motor responses, attention shifts, and semantic
processes. After the review of the corresponding evidence â so-called masked
priming effects â an approach based on the sensorimotor supremacy hypothesis is
detailed as to how the question of a unitary mechanism of unconscious vision can
be pursued by masked priming studies. In the second part of the report,
different models and theories of backward masking and masked priming are
reviewed. Types of models based on the sensorimotor hypothesis are discussed
that can take into account ways in which sensorimotor processes (reflected in
masked priming effects) can affect conscious vision under backward masking
conditions
Pediatric Measles Vaccine Expressing a Dengue Antigen Induces Durable Serotype-specific Neutralizing Antibodies to Dengue Virus
Dengue disease is an increasing global health problem that threatens one-third of the world's population. Despite decades of efforts, no licensed vaccine against dengue is available. With the aim to develop an affordable vaccine that could be used in young populations living in tropical areas, we evaluated a new strategy based on the expression of a minimal dengue antigen by a vector derived from pediatric live-attenuated Schwarz measles vaccine (MV). As a proof-of-concept, we inserted into the MV vector a sequence encoding a minimal combined dengue antigen composed of the envelope domain III (EDIII) fused to the ectodomain of the membrane protein (ectoM) from DV serotype-1. Immunization of mice susceptible to MV resulted in a long-term production of DV1 serotype-specific neutralizing antibodies. The presence of ectoM was critical to the immunogenicity of inserted EDIII. The adjuvant capacity of ectoM correlated with its ability to promote the maturation of dendritic cells and the secretion of proinflammatory and antiviral cytokines and chemokines involved in adaptive immunity. The protective efficacy of this vaccine should be studied in non-human primates. A combined measlesâdengue vaccine might provide a one-shot approach to immunize children against both diseases where they co-exist
Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands
Identification of functionally relevant determinants on the complement component c3 with monoclonal antibodies.
Differential Effect of a Bilateral Deep Cerebellar Nuclei Lesion on Externally and Internally Triggered Saccades in Humans
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