Technological activity in the european regions

This paper investigates technological activity in the European regions. The analysis is based on a statistical databank set up by CRENoS on regional patenting at the European Patent Office spanning from 1978 to 2001 and classified by ISIC sectors at the 2 digit level. We consider 175 regions of 17 countries in Europe, the 15 members of the European Union plus Switzerland and Norway. An analysis of the spatial distribution of innovation activities in Europe is performed. Some global and local indicators for spatial association are presented, signaling the presence of a general dependence process in the distribution of the phenomena under examination. The analysis is implemented for different manufacturing sectors to assess for the presence of significant differences in the their spatial features. Moreover, the extent and strength of spatial externalities are evaluated for some subperiods spanning from the early eighties to the late nineties

L'Econometria per le indagini territoriali: appunti metodologici e un'applicazione alla Sardegna

Il recente interesse scientifico per la new economic geography ha favorito il sorgere e il consolidarsi di un filone di ricerca di economia applicata che mira alla formalizzazione e misurazione delle relazioni spaziali fra fenomeni economici. Questa attività di ricerca, dapprima relegata in una nicchia accademica, oggi trova progressivamente applicazione nei corsi universitari, segno di una disciplina che suscita interesse per l’approccio innovativo all’indagine delle dinamiche sociali ed economiche. L’econometria spaziale nasce come branca dell’econometria tradizionale con la finalità di affrontare le problematiche connesse all’impiego di dati georeferenziati, cioè collegati ad entità geografiche. Fra i vari temi assumono rilevanza particolare l’interdipendenza (o autocorrelazione) e l’eterogeneità (o eteroschedasticità) spaziale. Per essi, troppo spesso, gli elementi forniti dalla econometria tradizionale appaiono insufficienti. Questo lavoro si propone di rendere esplicite le peculiarità proprie delle tecniche dell’econometria spaziale insieme ad alcune istruzioni d’uso per le loro applicazioni concrete

Association between attention and heart rate fluctuations in pathological worriers

Recent data suggests that several psychopathological conditions are associated with alterations in the variability of behavioral and physiological responses. Pathological worry, defined as the cognitive representation of a potential threat, has been associated with reduced variability of heart beat oscillations (i.e., decreased heart rate variability; HRV) and lapses of attention indexed by reaction times (RTs). Clinical populations with attention deficit show RTs oscillation around 0.05 and 0.01 Hz when performing a sustained attention task. We tested the hypothesis that people who are prone to worry do it in a predictable oscillating pattern revealed through recurrent lapses in attention and concomitant oscillating HRV. Sixty healthy young adults (50% women) were recruited: 30 exceeded the clinical cut-off on the Penn State Worry Questionnaire (PSWQ; High-Worry, HW); the remaining 30 constituted the Low-Worry (LW) group. After a diagnostic assessment, participants performed two 15-min sustained attention tasks, interspersed by a standardized worry-induction procedure. RTs, HRV and moods were assessed. The analyses of the frequency spectrum showed that the HW group presents a significant higher and constant peak of RTs oscillation around 0.01 Hz (period 100 s) after the induction of worry, in comparison with their baseline and with the LW group that was not responsive to the induction procedure. Physiologically, the induction significantly reduced high-frequency HRV and such reduction was associated with levels of self-reported worry. Results are coherent with the oscillatory nature of the default mode network (DMN) and further confirm an association between cognitive rigidity and autonomic nervous system inflexibility

Inclusione e leadership: il ruolo del dirigente scolastico nella promozione della valorizzazione delle differenze

Il contributo presenta i risultati emersi da una ricerca che ha coinvolto 24 dirigenti scolastici, che hanno partecipato a dei focus group sul loro ruolo nel favorire l’inclusione degli studenti con Bisogni Educativi Speciali. I focus group hanno focalizzato l’attenzione sulla responsabilità del capo d’istituto nella promozione del benessere a scuola di tutti gli studenti, specie di coloro che presentano maggiori difficoltà. Dall’indagine emerge la grande importanza del dirigente nel promuovere l’inclusione. La ricerca evidenzia, inoltre, la necessità di una maggiore formazione di tutto il personale scolastico (compresi i dirigenti) sulla pedagogia e didattica speciale, per avere strumenti più incisivi da realizzare per un clima più attento alla valorizzazione delle differenze.

Straightforward preparation of biologically active dimers of ferulic acid

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is an ubiquitous phenolic compound in plant tissues, and it constitutes a naturally occurring antioxidant compound found in many foods. Here we present different convenient ways to obtain five naturally occurring DiFAs via peroxidase-mediated oxidative coupling reactions or classic cross-coupling oxidations through a sustainable, safe and inexpensive chemistry. Such compounds arise from 5-5’, 8-8’, 8-5’ and 8-O-4’ coupling and some of them have been tested as potential inhibitors of micotoxin production in vitro

Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance

The antifungal activity of magnolol and honokiol, two naturally occurring hydroxylated biphenyls, and of their synthetic derivatives was evaluated on a collection of representative isolates of Fusarium oxysporum, F. solani and F. verticillioides of clinical and ecological concern. The tested compounds were proposed as a ‘natural’ alternative to conventional fungicides, even though a larger range of concentrations (5–400 μg/ml) was applied. The activity of magnolol and honokiol was compared with that of terbinafine (0.1–10 μg/ml), and fluconazole (1–50 μg/ml), two fungicides widely used in treating fungal infections on humans. Magnolol showed similar fungicidal activity compared to fluconazole, whereas honokiol was more effective in inhibiting mycelium growth compared to this fungicide on all tested clinical Fusarium spp. isolates. Compared to terbinafine, honokiol showed similar antifungal activity when tested on clinical F. solani isolates, whereas magnolol was less effective at all selected concentrations (5–400 μg/ml). The different position of the phenol-OH group, as well as its protection, explain different in vitro activities between magnolol, honokiol, and their derivatives. Furthermore, magnolol showed mycelium dry weight reduction at a concentration of 0.5 mM when tested on a set of agricultural isolates of Fusaria, leading to complete inhibition of some of them. Magnolol and honokiol are proposed as efficient and safe candidates for treating clinically relevant Fusaria.Fil: Oufensou, Safa. Università Degli Studi Di Sassari; ItaliaFil: Scherm, Barbara. Università Degli Studi Di Sassari; ItaliaFil: Pani, Giovanna. Università Degli Studi Di Sassari; ItaliaFil: Balmas, Virgilio. Università Degli Studi Di Sassari; ItaliaFil: Fabbri, Davide. Istituto Di Chimica Biomolecolare; ItaliaFil: Dettori, Maria Antonietta. Istituto Di Chimica Biomolecolare; ItaliaFil: Carta, Paola. Istituto Di Chimica Biomolecolare; ItaliaFil: Malbrán, Ismael. Universidad Nacional de La Plata. Facultad de Ciencias Agrarias y Forestales. Departamento de Ciencias Biológicas. Centro de Investigaciones de Fitopatología. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones de Fitopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Migheli, Quirico. Università Degli Studi Di Sassari; ItaliaFil: Delogu, Giovanna. Istituto Di Chimica Biomolecolare; Itali

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions