11 research outputs found
Death and the Societies of Late Antiquity
Ce volume bilingue, comprenant un ensemble de 28 contributions disponibles en français et en anglais (dans leur version longue ou abrĂ©gĂ©e), propose dâĂ©tablir un Ă©tat des lieux des rĂ©flexions, recherches et Ă©tudes conduites sur le fait funĂ©raire Ă lâĂ©poque tardo-antique au sein des provinces de lâEmpire romain et sur leurs rĂ©gions limitrophes, afin dâouvrir de nouvelles perspectives sur ses Ă©volutions possibles. Au cours des trois derniĂšres dĂ©cennies, les transformations considĂ©rables des mĂ©thodologies dĂ©ployĂ©es sur le terrain et en laboratoire ont permis un renouveau des questionnements sur les populations et les pratiques funĂ©raires de lâAntiquitĂ© tardive, pĂ©riode marquĂ©e par de multiples changements politiques, sociaux, dĂ©mographiques et culturels. Lâapparition de ce qui a Ă©tĂ© initialement dĂ©signĂ© comme une « Anthropologie de terrain », qui fut le dĂ©but de la dĂ©marche archĂ©othanatologique, puis le rĂ©cent dĂ©veloppement dâapproches collaboratives entre des domaines scientifiques divers (archĂ©othanatologie, biochimie et gĂ©ochimie, gĂ©nĂ©tique, histoire, Ă©pigraphie par exemple) ont Ă©tĂ© dĂ©cisives pour le renouvellement des problĂ©matiques dâĂ©tude : rĂ©vision dâanciens concepts comme apparition dâaxes dâanalyse inĂ©dits. Les recherches rassemblĂ©es dans cet ouvrage sont articulĂ©es autour de quatre grands thĂšmes : lâĂ©volution des pratiques funĂ©raires dans le temps, lâidentitĂ© sociale dans la mort, les ensembles funĂ©raires en transformation (organisation et topographie) et les territoires de lâempire (du cĆur aux marges). Ces Ă©tudes proposent un rĂ©examen et une rĂ©vision des donnĂ©es, tant anthropologiques quâarchĂ©ologiques ou historiques sur lâAntiquitĂ© tardive, et rĂ©vĂšlent, Ă cet Ă©gard, une mosaĂŻque de paysages politiques, sociaux et culturels singuliĂšrement riches et complexes. Elles accroissent nos connaissances sur le traitement des dĂ©funts, lâemplacement des aires funĂ©raires ou encore la structure des sĂ©pultures, en rĂ©vĂ©lant une diversitĂ© de pratiques, et permettent au final de relancer la rĂ©flexion sur la maniĂšre dont les sociĂ©tĂ©s tardo-antiques envisagent la mort et sur les Ă©lĂ©ments permettant dâidentifier et de dĂ©finir la diversitĂ© des groupes qui les composent. Elles dĂ©montrent ce faisant que nous pouvons vĂ©ritablement apprĂ©hender les structures culturelles et sociales des communautĂ©s anciennes et leurs potentielles transformations, Ă partir de lâĂ©tude des pratiques funĂ©raires.This bilingual volume proposes to draw up an assessment of the recent research conducted on funerary behavior during Late Antiquity in the provinces of the Roman Empire and on their borders, in order to open new perspectives on its possible developments. The considerable transformations of the methodologies have raised the need for a renewal of the questions on the funerary practices during Late Antiquity, a period marked by multiple political, social, demographic and cultural changes. The emergence field anthropology, which was the beginning of archaeothanatology, and then the recent development of collaborative approaches between various scientific fields (archaeothanatology, biochemistry and geochemistry, genetics, history, epigraphy, for example), have been decisive. The research collected in this book is structured around four main themes: Evolution of funerary practices over time; Social identity through death; Changing burial grounds (organisation and topography); Territories of the Empire (from the heart to the margins). These studies propose a review and a revision of the data, both anthropological and archaeological or historical on Late Antiquity, and reveal a mosaic of political, social, and cultural landscapes singularly rich and complex. In doing so, they demonstrate that we can truly understand the cultural and social structures of ancient communities and their potential transformations, based on the study of funerary practices
Simulated intestinal fluid as transport medium in the Caco-2 cell culture model
The Caco-2 model is widely used as a predictive tool for the oral absorption of drug candidates. Presently, transport experiments in the Caco-2 system are usually performed in 'HBSS-like' buffers. In this paper, we investigate the possibility of using simulated intestinal buffers as donor solvent during Caco-2 experiments. Toxicity assessment of these buffers on the monolayer showed that FASSIF was compatible with the Caco-2 model for at least 2 h. On the other hand, FESSIF was toxic to the monolayer. The functionality of the Caco-2 cells was assessed by determination of the transport of model compounds and the metabolic activity of hydrolases in presence of these buffers. Similar P(app) values for the (passive) theophyllin transport as well as for the (active) phenylalanine transport were obtained in TM and FASSIF. It was demonstrated that NaTC (present in FASSIF) had a P-gp inhibitory activity, as inclusion of NaTC in the apical compartment resulted in an increased absorptive and decreased secretory transport of CsA. The activity of the aminopeptidase enzyme was similar in both models. These results suggest that FASSIF can be used as an apical medium in the Caco-2 system. Since bile salts are also present in physiological conditions, the use of FASSIF may increase the relevance for the prediction of oral absorption using Caco-2 experiments.status: publishe
L'aide aux aidants en Alsace Bossue
STRASBOURG ILLKIRCH-Pharmacie (672182101) / SudocSudocFranceF
Transistor analogs of emergent iono-neuronal dynamics
Neuromorphic analog metal-oxide-silicon (MOS) transistor circuits promise compact, low-power, and high-speed emulations of iono-neuronal dynamics orders-of-magnitude faster than digital simulation. However, their inherently limited input voltage dynamic range vs power consumption and silicon die area tradeoffs makes them highly sensitive to transistor mismatch due to fabrication inaccuracy, device noise, and other nonidealities. This limitation precludes robust analog very-large-scale-integration (aVLSI) circuits implementation of emergent iono-neuronal dynamics computations beyond simple spiking with limited ion channel dynamics. Here we present versatile neuromorphic analog building-block circuits that afford near-maximum voltage dynamic range operating within the low-power MOS transistor weak-inversion regime which is ideal for aVLSI implementation or implantable biomimetic device applications. The fabricated microchip allowed robust realization of dynamic iono-neuronal computations such as coincidence detection of presynaptic spikes or pre- and postsynaptic activities. As a critical performance benchmark, the high-speed and highly interactive iono-neuronal simulation capability on-chip enabled our prompt discovery of a minimal model of chaotic pacemaker bursting, an emergent iono-neuronal behavior of fundamental biological significance which has hitherto defied experimental testing or computational exploration via conventional digital or analog simulations. These compact and power-efficient transistor analogs of emergent iono-neuronal dynamics open new avenues for next-generation neuromorphic, neuroprosthetic, and brain-machine interface applications
The coming decade of digital brain research - A vision for neuroscience at the intersection of technology and computing
Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales â from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europeâs Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are
To develop a concept for the coming decade of digital brain research
To discuss it with the research community at large, with the aim of identifying points of convergence and common goals
To provide a scientific framework for current and future development of EBRAINS
To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research
To identify and address key ethical and societal issues
While we do not claim that there is a âone size fits allâ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience.
Comments on this manuscript are welcome
This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here.
All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals.
New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after