Damage model for FRP-confined concrete columns under cyclic loading

International audienceIn structural engineering, seismic vulnerability reduction of existing structures is a crucial issue. External reinforcement with fiber-reinforced polymer (FRP) holds interest in achieving this aim. Its use as a retrofitting method is limited, however, for a number of reasons, including the lack of numerical tools for predicting cyclic loading. This paper presents a simplified stress-strain model suitable for monotonic and cycling loading capable of predicting the FRP's effect on reinforced-concrete columns. The model was inspired by two well-known concrete constitutive laws: one based on damage mechanics (La Borderie's concrete-damage model, 1991); the other on extensive experimental studies (Eid and Paultre's confined-concrete model, 2008). Validation is provided using experimental results on reinforced concrete columns subjected to axial and flexural cyclic loading. The proposed approach also deals with steel-bar rupture, considering low-cycle fatigue effects. All the simulations were conducted with multifiber Timoshenko beam elements

Stress-strain model for FRP-confined concrete columns under cyclic and seismic loading

In structural engineering, seismic vulnerability reduction of existing structures is a crucial issue. External reinforcement with fiber-reinforced polymer (FRP) holds interest in achieving this aim. Its use as a retrofitting method is limited, however, for a number of reasons, including the lack of numerical tools for predicting cyclic loading. This paper presents a simplified stress-strain model suitable for monotonic and cycling loading capable of predicting the FRP's effect on reinforced-concrete col umns. The model is inspired by two well-known concrete constitutive laws: one based on damage mechanics (La Borderie's concrete-damage model, 1991); the other on extensive experimental studies (Eid & Paultre's confined-concrete model, 2008). Validation is provided using experimental results on reinforced concrete columns subjected to axial and flexural cyclic loading. All the simulations were conducted with multifiber Timoshenko beam elements

Retrofitting reinforced concrete structures with FRP: Numerical simulations using multifiber beam elements

In structural engineering, seismic vulnerability reduction of existing structures is a crucial issue. External reinforcement by Polymer Reinforced Fibers (FRP) is an interesting tool in order to fulfill this aim. However, the use of FRP reinforcement as a retrofitting method is limited, one of the reasons being the lack of predicting numerical tools for cyclic loading. This paper presents a method to predict the behavior of beam-column structures considering the FRP reinforcement effect. It describes the construction of a 1D concrete constitutive model suitable for monotonic and cycling loadings. The model is inspired on two well-known concrete models, the first one based on the damage mechanics theory (La Borderie concrete damage model), and the second one based on experimental studies (Eid & Paultre's confined concrete model). Validation of the approach is done using experimental results on reinforced concrete beam and columns submitted to axial and flexural cyclic loading. The proposed method deals also with steel bar rupture considering low cycle fatigue effects. All the simulations are done using multifiber Timoshenko beam elements

Metabolic consequences of chronic sleep restriction in rats:Changes in body weight regulation and energy expenditure

Epidemiological studies have shown an association between short or disrupted sleep and an increased risk to develop obesity. In animal studies, however, sleep restriction leads to an attenuation of weight gain that cannot be explained by changes in energy intake. In the present study, we assessed whether the attenuated weight gain under conditions of restricted sleep is a consequence of an overall increase in energy expenditure. Adult male rats were subjected to a schedule of chronic sleep restriction (SR) for 8 days with a 4 h window of unrestricted rest per day. Electroencephalogram and electromyogram recordings were performed to quantify the effect of the sleep restriction schedule on sleep-wake patterns. In a separate experiment, we measured sleep restriction-induced changes in body weight, food intake, and regulatory hormones such as glucose, insulin, leptin and corticosterone. To investigate whether a change in energy expenditure underlies the attenuation of weight gain, energy expenditure was measured by the doubly labeled water method from day 5 until day 8 of the SR protocol. Results show a clear attenuation of weight gain during sleep restriction but no change in food intake. Baseline plasma glucose, insulin and leptin levels are decreased after sleep restriction which presumably reflects the nutritional status of the rats. The daily energy expenditure during SR was significantly increased compared to control rats. Together, we conclude that the attenuation of body weight gain in sleep restricted rats is explained by an overall increase in energy expenditure together with an unaltered energy intake. Published by Elsevier Inc

Modèle cyclique de béton confiné par TFC pour poteaux circulaires en béton armé

International audienceIn structural engineering, the seismic vulnerability reduction of existing structures is a crucial issue. External reinforcement using Fiber Reinforced Polymer (FRP) is an interesting tool in order to fulfill this aim.This paper presents a method to simulate the behavior of existing columns considering FRP reinforcement effect. It describes the construction of a 1D confined concrete behavior law suitable for monotonic and cycling loadings. The law is inspired on two well-known concrete laws, the first one based on damage mechanics theory (La Borderie concrete damage law) and the second one based on experimental studies (Eid & Paultre concrete monotonic law). Structures are discretized using multifiber beam elements. Validation of the approach is provided using experimental tests of RC columns under axial and flexural cyclic loading.En génie parasismique, la réduction de la vulnérabilité des structures existantes est un enjeux majeur. Le renforcement externe d'éléments par collage de Tissus de Fibre de Carbone (TFC) est une réponse intéressanteà cette problématique. Cet article présente la construction d'un modèle uniaxial de béton confiné adapté au cas des chargements monotones et cycliques. Ce modèle est fondé sur deux modèles bien connus, le premier basé sur la théorie de l'endommagement (La Borderie) et le second basé sur une série d'études expérimentales (Eid & Paultre). Le modèle est implanté dans un codé eléments finis multifibres. Une validation expérimentale de ce modèle est menée enétudiant le cas de poteaux en béton armé soumisà un chargement cyclique de flexion composée

A mode-of-action ontology model for safety evaluation of chemicals: outcome of a series of workshops on repeated dose toxicity

Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this challenge is linked to the capacity to cover a comprehensive set of interdependent mechanisms of action, link them to adverse effects and interpret their probability to be triggered in the light of the exposure at the (sub)cellular level. Inherent to its structured nature, an ontology addressing repeated dose toxicity could be a scientific and transparent way to achieve this goal. Additionally, repeated dose toxicity evaluation through the use of a harmonized ontology should be performed in a reproducible and consistent manner, while mimicking as accurately as possible human physiology and adaptivity. In this paper, the outcome of a series of workshops organized by Cosmetics Europe on this topic is reported. As such, this manuscript shows how experts set critical elements and ways of establishing a mode-of-action ontology model as a support to risk assessors aiming to perform animal-free safety evaluation of chemicals based on repeated dose toxicity data

Challenges in working towards an internal Threshold of Toxicological Concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

The Threshold of Toxicological Concern (TTC) is an important risk assessment tool which establishes acceptable low-level exposure values to be applied to chemicals with limited toxicological data. One of the logical next steps in the continued evolution of TTC is to develop this concept further so that it is representative of internal exposures (TTC based on plasma concentration). An internal TTC (iTTC) would provide threshold values that could be utilized in exposure-based safety assessments. As part of a Cosmetics Europe (CosEu) research program, CosEu has initiated a project that is working towards the development of iTTCs that can be used for the human safety assessment. Knowing that the development of an iTTC is an ambitious and broad-spanning topic, CosEu organized a Working Group comprised a balance of multiple stakeholders (cosmetics and chemical industries, the EPA and JRC and academia) with relevant experience and expertise and workshop to critically evaluate the requirements to establish an iTTC. Outcomes from the workshop included an evaluation on the current state of the science for iTTC, the overall iTTC strategy, selection of chemical databases, capture and curation of chemical information, ADME and repeat dose data, expected challenges, as well as next steps and ongoing work

A novel, cellulose synthesis inhibitory action of ancymidol impairs plant cell expansion

The co-ordination of cell wall synthesis with plant cell expansion is an important topic of contemporary plant biology research. In studies of cell wall synthesis pathways, cellulose synthesis inhibitors are broadly used. It is demonstrated here that ancymidol, known as a plant growth retardant primarily affecting gibberellin biosynthesis, is also capable of inhibiting cellulose synthesis. Its ability to inhibit cellulose synthesis is not related to its anti-gibberellin action and possesses some unique features never previously observed when conventional cellulose synthesis inhibitors were used. It is suggested that ancymidol targets the cell wall synthesis pathway at a regulatory step where cell wall synthesis and cell expansion are coupled. The elucidation of the ancymidol target in plant cells could potentially contribute to our understanding of cell wall synthesis and cell expansion control

Impacts of climate change on plant diseases – opinions and trends

There has been a remarkable scientific output on the topic of how climate change is likely to affect plant diseases in the coming decades. This review addresses the need for review of this burgeoning literature by summarizing opinions of previous reviews and trends in recent studies on the impacts of climate change on plant health. Sudden Oak Death is used as an introductory case study: Californian forests could become even more susceptible to this emerging plant disease, if spring precipitations will be accompanied by warmer temperatures, although climate shifts may also affect the current synchronicity between host cambium activity and pathogen colonization rate. A summary of observed and predicted climate changes, as well as of direct effects of climate change on pathosystems, is provided. Prediction and management of climate change effects on plant health are complicated by indirect effects and the interactions with global change drivers. Uncertainty in models of plant disease development under climate change calls for a diversity of management strategies, from more participatory approaches to interdisciplinary science. Involvement of stakeholders and scientists from outside plant pathology shows the importance of trade-offs, for example in the land-sharing vs. sparing debate. Further research is needed on climate change and plant health in mountain, boreal, Mediterranean and tropical regions, with multiple climate change factors and scenarios (including our responses to it, e.g. the assisted migration of plants), in relation to endophytes, viruses and mycorrhiza, using long-term and large-scale datasets and considering various plant disease control methods