Placenta percreta following first trimester miscarriage

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135586/1/ijgo140.pd

Metodología analítica para la determinación de policosanol en tabletas revestidas con dosis de 20 mg

Las tabletas revestidas, con dosis de 20 mg de policosanol, fueron recientemente desarrolladas debido a la necesidad de facilitar la administración de este fármaco a los pacientes que requieren dicha dosis, la cual es la más elevada dosis diaria recomendada.1 Teniendo en cuenta las exigencias actuales de la Industria Farmacéutica en cuanto a la necesidad de contar con un método analítico validado que permita realizar el control de calidad y los estudios de estabilidad a cada nueva forma farmacéutica,2 se adaptó la metodología utilizada en el análisis de las tabletas con dosis de 10 mg de policosanol3 y en estas condiciones se realizó la validación del método para este nuevo producto

A Universal Decline Law of Classical Novae. III. GQ Mus 1983

We present a unified model of infrared (IR), optical, ultraviolet (UV), and X-ray light curves for the 1983 outburst of GQ Muscae (Nova Muscae 1983) and estimate its white dwarf (WD) mass. Based on an optically thick wind model of nova outbursts, we model the optical and IR light curves with free-free emission, and the UV 1455 \AA and supersoft X-ray light curves with blackbody emission. The best fit model that reproduces simultaneously the IR, optical, UV 1455 \AA, and supersoft X-ray observations is a 0.7 \pm 0.05 M_\sun WD for an assumed chemical composition of the envelope, X=0.35-0.55, X_{CNO} =0.2-0.35, and Z = 0.02, by mass weight. The mass lost by the wind is estimated to be \Delta M_{wind} \sim 2 \times 10^{-5} M_\sun. We provide a new determination of the reddening, E(B-V) = 0.55 \pm 0.05, and of the distance, \sim 5 kpc. Finally, we discuss the strong UV flash that took place on JD 2,445,499 (151 days after the outburst).Comment: to appear in ApJ, 17 pages including 20 figure

Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study

Objective To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen. Methods We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls). Results 57 patients (93% women) were included with a median age of 54 years [45–63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6–12] vs. 2 [1–4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5–77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens. Conclusion pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined

Syndrome de platypnée-orthodéoxie : une cause rare d’hypoxémie sévère

International audienceIntroduction: The platypnea-orthodeoxia syndrome (PO) includes: (i) a dyspnea increasing with orthostatism and decreasing in supine position, (ii) wide positional range in arterial oxygen saturation with tachycardia, (iii) and hypoxemia refractory to oxygen therapy. This syndrome is usually related to a cardiac right-left shunt, and rarely to a pulmonary shunt.Observation: We report a case of a patient presenting with a post-lung infection dyspnea associated with severe hypoxemia and shunt effect at blood gas. Contrast-enhanced CT-scan showed no pulmonary embolism. PO syndrome was suspected given the transcutaneous blood oxygen saturation variation from 90% in supine position to 60% in standing position, tachycardia, and absence of response to the intensive oxygen therapy.Conclusion: This syndrome should be known by physicians as a possible differential diagnose for refractory dyspnea to oxygen since effective treatment is available

Evolution spatiale et temporelle des pesticides dans un réseau de canaux

A liquid-liquid extraction method using pulsed column was performed to quantify at the ng/l level the pesticide pollution effect. Over a period of one year on the Languedoc-Roussillon area, the surface water of a canal network fed by the Rhône river was analysed in order to identify organic pollutants. Among the 110 substances found by this method, 7 are pesticides : lindane, alachlor, metolachlor, methyl parathion, simazine, terbutylazine and atrazine. This study permit to know their concentration evolution as a function of seasons, rain and swelling. A spatial evolution was shown their slow disapearance along the canal, phenomenon explained by their degradation or sedimentation. / Dans le but de quantifier l'effet de pollution des pesticides, une technique d'extraction liquide-liquide par colonne pulsée est mise en oeuvre permettant leur détection à des teneurs allant jusqu'au ng/l. Durant un an, la composition organique des eaux d'un réseau de canaux, situé en région Languedoc-Roussillon et alimenté par l'eau du Rhône, a été étudiée. Cette recherche s'est concrétisée par la détection et la quantification de 110 composés dont 7 pesticides : lindane, alachlor, métolachlor, méthyl parathion, simazine, terbutylazine et atrazine. Cette étude a permis de connaître l'évolution de leur concentration en fonction des saisons, des épisodes pluvieux et des crues. Un suivi spatial a montré leur lente disparition le long du canal, phénomène expliqué par leur dégradation ou leur sédimentation

Pneumopathies sévères à Cytomégalovirus et broncho-pneumopathie chronique obstructive

International audienceSummary: Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease.Introduction: We describe two cases of immunocompetent patients with chronic obstructive pulmonary disease (COPD) who developed severe cytomegalovirus (CMV) pneumonia. The clinical and radiological context and CMV replication in broncho-alveolar lavage suggested a diagnosis of CMV pneumonia.Case histories: We report two cases in patients with moderate chronic obstructive pulmonary disease not treated with long-term steroid therapy who developed bilateral pneumonia with hypoxaemia. The only pathogen identified was CMV with replication of the virus in the broncho-alveolar lavage. Investigation failed to detect any associated immune deficiency.Conclusion: Severe cytomegalovirus pneumonia could be encouraged by the existence of chronic obstructive pulmonary disease due to local inflammatory changes