1,185 research outputs found
Kinetic pathways of the Nematic-Isotropic phase transition as studied by confocal microscopy on rod-like viruses
We investigate the kinetics of phase separation for a mixture of rodlike
viruses (fd) and polymer (dextran), which effectively constitutes a system of
attractive rods. This dispersion is quenched from a flow-induced fully nematic
state into the region where the nematic and the isotropic phase coexist. We
show experimental evidence that the kinetic pathway depends on the overall
concentration. When the quench is made at high concentrations, the system is
meta-stable and we observe typical nucleation-and-growth. For quenches at low
concentration the system is unstable and the system undergoes a spinodal
decomposition. At intermediate concentrations we see the transition between
both demixing processes, where we locate the spinodal point.Comment: 11 pages, 6 figures, accepted in J. Phys.: Condens. Matter as
symposium paper for the 6th Liquid Matter Conference in Utrech
Kinetics of absorption of carbon dioxide in aqueous ammonia solutions
AbstractIn the present work the absorption of carbon dioxide into aqueous ammonia solutions has been studied in a stirred cell reactor, at low temperatures and ammonia concentrations ranging from 0.1 to about 7 kmol m−3. The absorption experiments were carried out at conditions where the so-called pseudo first order mass transfer regime was obeyed–and hence the kinetics of the reaction between carbon dioxide and ammonia could be derived. The results were interpreted according to the well-established zwitterion mechanism
Integration through transients for Brownian particles under steady shear
Starting from the microscopic Smoluchowski equation for interacting Brownian
particles under stationary shearing, exact expressions for shear-dependent
steady-state averages, correlation and structure functions, and
susceptibilities are obtained, which take the form of generalized Green-Kubo
relations. They require integration of transient dynamics. Equations of motion
with memory effects for transient density fluctuation functions are derived
from the same microscopic starting point. We argue that the derived formal
expressions provide useful starting points for approximations in order to
describe the stationary non-equilibrium state of steadily sheared dense
colloidal dispersions.Comment: 17 pages, Submitted to J. Phys.: Condens. Matter; revised version
with minor correction
Emerging evidence for CHFR as a cancer biomarker : from tumor biology to precision medicine
Novel insights in the biology of cancer have switched the paradigm of a "one-size-fits-all" cancer treatment to an individualized biology-driven treatment approach. In recent years, a diversity of biomarkers and targeted therapies has been discovered. Although these examples accentuate the promise of personalized cancer treatment, for most cancers and cancer subgroups no biomarkers and effective targeted therapy are available. The great majority of patients still receive unselected standard therapies with no use of their individual molecular characteristics. Better knowledge about the underlying tumor biology will lead the way toward personalized cancer treatment. In this review, we summarize the evidence for a promising cancer biomarker: checkpoint with forkhead and ring finger domains (CHFR). CHFR is a mitotic checkpoint and tumor suppressor gene, which is inactivated in a diverse group of solid malignancies, mostly by promoter CpG island methylation. CHFR inactivation has shown to be an indicator of poor prognosis and sensitivity to taxane-based chemotherapy. Here we summarize the current knowledge of altered CHFR expression in cancer, the impact on tumor biology and implications for personalized cancer treatment
Cavitation-induced force transition in confined viscous liquids under traction
We perform traction experiments on simple liquids highly confined between
parallel plates. At small separation rates, we observe a simple response
corresponding to a convergent Poiseuille flow. Dramatic changes in the force
response occur at high separation rates, with the appearance of a force plateau
followed by an abrupt drop. By direct observation in the course of the
experiment, we show that cavitation accounts for these features which are
reminiscent of the utmost complex behavior of adhesive films under traction.
Surprisingly enough, this is observed here in purely viscous fluids.Comment: Submitted to Physical Review Letters on May 31, 2002. Related
informations on http://www.crpp.u-bordeaux.fr/tack.htm
The association of early life socioeconomic conditions with prediabetes and type 2 diabetes: results from the Maastricht study
markdownabstractBackground: Using cross-sectional data from The Maastricht Study, we examined the association of socioeconomic conditions in early life with prediabetes and T2DM in adulthood. We also examined potential mediating pathways via both adulthood socioeconomic conditions and adult BMI and health behaviours.
Methods: Of the 3263 participants (aged 40-75 years), 493 had prediabetes and 906 were diagnosed with T2DM. By using logistic regression analyses, the associations and possible mediating pathways were examined.
Results: Participants with low early life socioeconomic conditions had a 1.56 times higher odds of prediabetes (95% confidence interval (CI) = 1.21-2.02) and a 1.61 times higher odds of T2DM (95% CI = 1.31-1.99). The relation between low early life socioeconomic conditions and prediabetes was independent of current socioeconomic conditions (OR = 1.38, 95% CI = 1.05-1.80), whereas the relation with T2DM was not independent of current socioeconomic conditions (OR = 1.10, 95% CI = 0.87-1.37). BMI party mediated the association between early life socioeconomic conditions and prediabetes.
Conclusions: Socioeconomic inequalities starting in early life were associated with diabetes-related outcomes in adulthood and suggest the usefulness of early life interventions aimed at tackling these inequalities
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