Cal Poly Dining: The Avenue Redesign

Executive Summary Campus Dining is planning to close VG’s Cafe during the 2015-2016 school year; as a result, the remaining restaurants on campus need to accommodate the additional student demand. The student team consisting of Eric Calbonero, Derek Nollsch, and Casey Reilly met with Campus Dining’s Director of Operations, Greg Yeo, about this issue—he directed the team toward a redesign of The Avenue Food Court. To redesign The Avenue, the project team focused on several key deliverables as follows: Study current customer trends in The Avenue Develop a proposed facilities layout and design Perform a capacity analysis of The Avenue Technical Report of Findings First, the project team needed to define key stakeholders and communicate their goals. After this, the team observed the Avenue and performed the following time studies: customer inter-arrival time, register processing time, and the processing times of each of the restaurants in The Avenue. These observations were done to create a current state 2D and 3D model of the restaurant. Next, the project team created a simulation model of The Avenue to test each of four different experiments on the system. The first experiment was to test the result of the projected 10% increase in customer demand. The second experiment was to test the result of equal demand across all restaurants. The third experiment was to test the result of an equal processing time across all restaurants. Finally, the fourth experiment was to test the result of increasing the number of register queues from three to four. After performing the experiments on the simulation model, the project team was able to create a 2D and 3D model of the proposed changes to The Avenue. The proposed changes were as follows: Replace the salad bar with a smaller, tiered design Add an additional restaurant with the necessary equipment Simplify menus to reduce processing time Add two additional POS stations with an associated queue As a result of the projected 10% increase in sales, The Avenue is projected to earn an additional $1,663 in revenues per day. However, the proposed changes are expected to cost a total of$33,500—resulting in a payback period of 20.14 business days

MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease

MicroRNA (miRNA) has the potential for cross-regulation and functional integration of discrete biological processes during complex physiological events. Utilizing the common human condition tendinopathy as a model system to explore the cross-regulation of immediate inflammation and matrix synthesis by miRNA we observed that elevated IL-33 expression is a characteristic of early tendinopathy. Using in vitro tenocyte cultures and in vivo models of tendon damage, we demonstrate that such IL-33 expression plays a pivotal role in the transition from type 1 to type 3 collagen (Col3) synthesis and thus early tendon remodelling. Both IL-33 effector function, via its decoy receptor sST2, and Col3 synthesis are regulated by miRNA29a. Downregulation of miRNA29a in human tenocytes is sufficient to induce an increase in Col3 expression. These data provide a molecular mechanism of miRNA-mediated integration of the early pathophysiologic events that facilitate tissue remodelling in human tendon after injury

Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis

Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy. Methods: Torn supraspinatus tendon (established pathology) and matched intact subscapularis tendon (representing ‘early pathology’) biopsies were collected from patients undergoing arthroscopic shoulder surgery. Control samples of subscapularis tendon were collected from patients undergoing arthroscopic stabilisation surgery. Markers of inflammation and HMGB1 were quantified by reverse transcriptase PCR (RT-PCR) and immunohistochemistry. Human tendon-derived primary cells were derived from hamstring tendon tissue obtained during hamstring tendon anterior cruciate ligament reconstruction and used through passage 3. In vitro effects of recombinant HMGB1 on tenocyte matrix and inflammatory potential were measured using quantitative RT-PCR, ELISA and immunohistochemistry staining. Results: Tendinopathic tissues demonstrated significantly increased levels of the danger molecule HMGB1 compared with control tissues with early tendinopathy tissue showing the greatest expression. The addition of recombinant human HMGB1 to tenocytes led to significant increase in expression of a number of inflammatory mediators, including interleukin 1 beta (IL-1β), IL-6, IL-33, CCL2 and CXCL12, in vitro. Further analysis demonstrated rhHMGB1 treatment resulted in increased expression of genes involved in matrix remodelling. Significant increases were observed in Col3, Tenascin-C and Decorin. Moreover, blocking HMGB1 signalling via toll-like receptor 4 (TLR4) silencing reversed these key inflammatory and matrix changes. Conclusion: HMGB1 is present in human tendinopathy and can regulate inflammatory cytokines and matrix changes. We propose HMGB1 as a mediator driving the inflammatory/matrix crosstalk and manipulation of the HMGB1/TLR4 axis may offer novel therapeutic approaches targeting inflammatory mechanisms in the management of human tendon disorders

Understanding and Evaluating Quality of Life for Individuals with Intellectual Disabilities: A Northwestern Vermont Population Study

Introduction There are 7-8 million individuals with intellectual or developmental disabilities living in the US. • 91,795 of this population lives in Vermont • Historically marginalized and isolated community • Socioeconomic, health-related, and emotional burden • Public health-related disparity Champlain Community Services (CCS): non-profit service provider and coordinator for 86 persons with intellectual disabilities in Northwestern Vermont Objectives: • Develop and apply measures to better understand and evaluate quality of life in the population CCS serves. • Recommend improvement to CCS data collection and evaluation methods. • Provide a basis for future recommendations to CCS services that are aligned to the needs of consumers.https://scholarworks.uvm.edu/comphp_gallery/1275/thumbnail.jp

Achieving integrated self-directed Cancer aftercare (ASICA) for melanoma: how a digital intervention to support total skin self-examination was used by people treated for cutaneous melanoma.

BACKGROUND: Melanoma incidence has quadrupled since 1970 and melanoma is now the second most common cancer in individuals under 50. Targeted immunotherapies for melanoma now potentially enable long-term remission even in advanced melanoma, but these melanoma survivors require ongoing surveillance, with implications for NHS resources and significant social and psychological consequences for patients. Total skin self-examination (TSSE) can detect recurrence earlier and improve clinical outcomes but is underperformed in the UK. To support survivors, the Achieving Self-directed Integrated Cancer Aftercare (ASICA) intervention was developed to prompt and improve TSSE performance, with subsequent reporting of concerns and submission of skin photos to a Dermatology Nurse Practitioner (DNP). ASICA was delivered as a randomized pilot trial. METHODS: This paper reports on process evaluation. Data on participants' demographics and the concerns they reported during the trial were tabulated and displayed using Microsoft Excel and SPSS. We explored which participants used ASICA, and how frequently, to report any skin concerns. We also determined how the interactions had worked in terms of quality of skin photographs submitted, clinical assessments made by the DNP, and the assessments and decisions made for each concern. Finally, we explored significant events occurring during the trial. Data on participants' demographics and the concerns they reported during the trial were tabulated and displayed using SPSS. A semi-structured interview was undertaken with the DNP to gain perspective on the range of concerns presented and how they were resolved. RESULTS: Of 121 recruited melanoma patients receiving ASICA for 12 months, 69 participants submitted a total of 123 reports detailing 189 separate skin-related concerns and including 188 skin photographs. Where participants fully complied with follow-up by the DNP, concerns were usually resolved remotely, but 19 (10.1%) were seen at a secondary care clinic and 14 (7.4%) referred to their GP. 49 (25.9%) of concerns were not completely resolved due to partial non-compliance with DNP follow-up. CONCLUSION: Melanoma patients randomized to the ASICA intervention were able to report skin-related concerns that could be resolved remotely through interaction with a DNP. Feasibility issues highlighted by ASICA will support further development and optimization of this digital tool. TRIAL REGISTRATION: Clinical Trials.gov , NCT03328247 . Registered on 1 November 2017

The Grizzly, February 20, 1981

SAC Approves Spring Term 1981 Allocations • SPC to Propose Journalism Seminar • USGA Announces New Officers • Grizzly Planning Satire Issue • Professional Credentials Committee Explored • Departmental Focus: Biology Department • USGA Notes • Astronomy Club Planning Open House • Music News Defends JDB • Lorelei Outcast • Alumni Office Sponsors Homecoming II • Sorority Pledging With Frats • Graterford Visit Provides New Insights • Classics Club Planning Another Trip • Special Olympics Slated for March • Athletic Department Announces Play-off Plans • Sports Profile: Greg Gifford • Basketball Team Clinches MAC Southern Division • Textile Downs Lady Hoopsters • Grapplers: 10-5-1https://digitalcommons.ursinus.edu/grizzlynews/1053/thumbnail.jp

The gas-phase structure of the decasilsesquioxane Si₁₀O₁₅H₁₀

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