Optical-inertia space sextant for an advanced space navigation system, phase B

Optical-inertia space sextant for advanced space navigation syste

The development of thirty self-administering and self-scoring elaborative thinking exercises

Thesis (Ed.M.)--Boston Universit

Mining for Process Improvements: Analyzing Software Repositories in Agile Retrospectives

Software Repositories contain knowledge on how software engineering teams work, communicate, and collaborate. It can be used to develop a data-informed view of a team's development process, which in turn can be employed for process improvement initiatives. In modern, Agile development methods, process improvement takes place in Retrospective meetings, in which the last development iteration is discussed. However, previously proposed activities that take place in these meetings often do not rely on project data, instead depending solely on the perceptions of team members. We propose new Retrospective activities, based on mining the software repositories of individual teams, to complement existing approaches with more objective, data-informed process views.Comment: In IEEE/ACM 42nd International Conference on Software Engineering Workshops (ICSEW'20

Developing and Validating a Risk Score for Lower-Extremity Amputation in Patients Hospitalized for a Diabetic Foot Infection

Objective: Diabetic foot infection is the predominant predisposing factor to nontraumatic lower-extremity amputation (LEA), but few studies have investigated which specific risk factors are most associated with LEA. We sought to develop and validate a risk score to aid in the early identification of patients hospitalized for diabetic foot infection who are at highest risk of LEA. Research Design and Methods: Using a large, clinical research database (CareFusion), we identified patients hospitalized at 97 hospitals in the U.S. between 2003 and 2007 for culture-documented diabetic foot infection. Candidate risk factors for LEA included demographic data, clinical presentation, chronic diseases, and recent previous hospitalization. We fit a logistic regression model using 75% of the population and converted the model coefficients to a numeric risk score. We then validated the score using the remaining 25% of patients. Results: Among 3,018 eligible patients, 21.4% underwent an LEA. The risk factors most highly associated with LEA (P 11,000 per mm3. The model showed good discrimination (c-statistic 0.76) and excellent calibration (Hosmer-Lemeshow, P = 0.63). The risk score stratified patients into five groups, demonstrating a graded relation to LEA risk (P < 0.0001). The LEA rates (derivation and validation cohorts) were 0% for patients with a score of 0 and ~50% for those with a score of ≥21. Conclusions: Using a large, hospitalized population, we developed and validated a risk score that seems to accurately stratify the risk of LEA among patients hospitalized for a diabetic foot infection. This score may help to identify high-risk patients upon admission

Prognostic value of the ratio between prothesis area and indexed annulus area measured by multiSlice-CT for transcatheter aortic valve implantation procedures

Background Postprocedural aortic regurgitations following transcatheter aortic valve implantation (TAVI) procedures remain an is- sue. Benefit of oversizing strategies to prevent them isn’t well established. We compared different level of oversizing in our cohort of con- secutive patients to address if severe oversizing compared to normal sizing had an impact on post-procedural outcomes. Methods From January 2010 to August 2013, consecutive patients were referred for TAVI with preoperative Multislice-CT (MSCT) and the procedures were achieved using Edwards Sapien® or Corevalve devices®. Retrospectively, according to pre-procedural MSCT and the valve size, pa- tients were classified into three groups: normal, moderate and severe oversizing; depending on the ratio between the prosthesis area and the annulus area indexed and measured on MSCT. Main endpoint was mid-term mortality and secondary endpoints were the Valve Academic Research Consortium (VARC-2) endpoints. Results Two hundred and sixty eight patients had a MSCT and underwent TAVI procedure, with mainly Corevalve®. While all-cause and cardiovascular mortality rates were similar in all groups, post-procedural new pacemaker (PM) implantation rate was significantly higher in the severe oversizing group (P = 0.03), while we observed more in-hospital congestive heart-failure (P = 0.02) in the normal sizing group. There was a trend toward more moderate to severe aortic regurgitation (AR) in the normal sizing group (P = 0.07). Conclusions Despite a higher rate of PM implantation, oversizing based on this ratio reduces aortic leak with lower rates of post-procedural complications and a similar mid-term survival

PREDICTION OF LOW ENGINE ORDER INLET DISTORTION DRIVEN RESONANCE IN A LOW ASPECT RATIO FAN

ABSTRACT This paper presents a forced response prediction of 3 resonances in a low aspect ratio modern fan rotor and compares with other worker&apos;s experimental data. The incoming disturbances are due to low engine-order inlet distortion from upstream screens. The resonances occur in the running range at 3 and 8 engine orders which cross low modes (flap, torsion and stripe) of the blade. The fan was tested with on-blade instrumentation at both on-and off-resonant conditions to establish the unsteady pressures due to known distortion patterns. The resulting steady and unsteady flow in the fan blade passages has been predicted by three methods, all threedimensional. The first is a linearised unsteady Euler method; the second is a non-linear unsteady Navier-Stokes method; the third method uses a similar level of aerodynamic modelling as the second but also includes a coupled model of the structural dynamics. The predictions for the 3 methods are presented against the test data, and further insight into the problem is obtained through post-processing of the data. Predictions of the blade vibration response are also obtained. Overall the level of agreement between calculations and measurements is considered encouraging although further research is needed

The role of a thermally sprayed CuNiIn underlayer in the durability of a dry-film lubricant system in fretting: a phenomenological model

Dry film lubricant coatings (DFL) are employed to reduce friction and damage in highly loaded contacts. Metallic underlayers, e.g. CuNiIn, can be beneficial however, there is no detailed explanation of the mechanism. This work investigates the effect of CuNiIn on fretting of a MoS2-based DFL in a cylinder-on-flat contact with a fretting amplitude of 300 µm. Two test types were run: 1. DFL without CuNiIn; 2. DFL on the cylindrical sample and DFL with CuNiIn underlayer on the flat sample. The CuNiIn increased the system’s durability. A phenomenological model highlighting the important low friction and highly wear resistant interfacial material is developed. The increased durability is ascribed to the high roughness of the CuNiIn onto which the DFL was deposited

Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects

CD8+ cytotoxic T lymphocyte (CTL) activity is currently believed to be one of the key immunologic mechanisms responsible for the prevention or attenuation of HIV-1 infection. The induction of CD8+ T cell activation may also result in the production of soluble or non-classical lytic factors that are associated with protection from infection or slower disease progression. Traditionally, CD8+ CTL responses have been measured by the classic chromium release assay, monitoring the ability of T cells (Effector cells) to lyse radiolabelled HLA – matched “target cells” that express the appropriate antigen-MHC complex. This method is not only labor intensive, semi quantitative assay at best, but also needs fresh, non-cryopreserved cells. Recently, cytokine specific ELISPOT assays or tetrameric MHC-I/ peptide complexes have utilized to directly quantitate circulating CD8+ effector cells, and these assays are more sensitive, quantitative and reproducible than the traditional CTL lysis assay and can also be performed on cryopreserved cells. Although these are reproducible assays for the assessment of soluble antiviral activity secreted by activated T cell populations they can be extremely expensive to perform. We have used FACS Analysis to measure Granzyme B release as a function of cell mediated cytotoxicity. This method helps quantitate the CTL activity and also identifies the phenotype of the cells elucidating this immune response. The method described not only monitors immunological response but also is also simple to perform, precise and extremely time efficient and is ideal for screening a large number of samples