Remarks of James E. Denny before the Study Group on Legal Remedies, Commission on Government Procurement

Legalities of patent infringements resulting from government procurement policie

Rapid recreation assessment: a tool to assess visitor use and associated impacts at coastal and marine protected areas

As more people discover coastal and marine protected areas as destinations for leisure-time pursuits, the task of managing coastal resources while providing opportunities for high quality visitor experiences becomes more challenging. Many human impacts occur at these sites; some are caused by recreation and leisure activities on-site, and others by activities such as agriculture, aquaculture, or residential and economic development in surrounding areas. Coastal management professionals are continually looking for effective ways to prevent or mitigate negative impacts of visitor use. (PDF contains 8 pages) Most coastal and marine protected area managers are challenged with balancing two competing goals—protection of natural and cultural resources and provision of opportunities for public use. In most cases, some level of compromise between the goals is necessary, where one goal constrains or “outweighs” the other. Often there is a lack of clear agreement about the priority of these competing goals. Consequently, while natural resource decisions should ultimately be science-based and objective, such decisions are frequently made under uncertainty, relying heavily upon professional judgment. These decisions are subject to a complex array of formal and informal drivers and constraints—data availability, timing, legal mandate, political will, diverse public opinion, and physical, human, and social capital. This paper highlights assessment, monitoring, and planning approaches useful to gauge existing resource and social conditions, determine feasibility of management actions, and record decision process steps to enhance defensibility. Examples are presented from pilot efforts conducted at the Rookery Bay National Estuarine Research Reserve (NERR) and Ten Thousand Islands National Wildlife Refuge (NWR) in South Florida

Tuning gastropod locomotion: Modeling the influence of mucus rheology on the cost of crawling

Common gastropods such as snails crawl on a solid substrate by propagating muscular waves of shear stress on a viscoelastic mucus. Producing the mucus accounts for the largest component in the gastropod's energy budget, more than twenty times the amount of mechanical work used in crawling. Using a simple mechanical model, we show that the shear-thinning properties of the mucus favor a decrease in the amount of mucus necessary for crawling, thereby decreasing the overall energetic cost of locomotion.Comment: Corrected typo

Can the Ayres Spelling Scale be Relied on for Measuring the Individual Class Achievement?

Twenty words were selected at random from column Q of the Ayres Spelling Scale. These words were given as a dictated spelling test to 29 pupils in the 5th grade of the I. S. T. C. Training School. The papers were scored and it was also determined how many times each word was missed. The ten easiest words were then considered as one test and the ten most difficult words as a second test

Preacher\u27s Magazine Volume 72 Number 02

EDITORIAL Thanks to an Old Friend and Welcome to a New Feature, Randal E. Denny FEATURE Judgment, She Wrote, Wesley D. Tracy; How Pastors Can Bring Unity, Robert Moeller PREACHING Preach, Pastor!, Harold R. Crosser; Stump Preaching, Frank Eifert CHRISTIAN HOLIDAYS Caesar or Christ?, C. S. Cowles; The Word Became Flesh: A Christmas Reading, Peter A. Samuelson; Christmas Reminds Us Babies Are Important, Morris Chalfant; Senior Ornaments on Our Tree, J. Grant Swank Jr. PASTOR, BE ENCOURAGED The Barren Times, C. Neil Strait CHRISTIAN MINISTRY Public Ministry, Private Pain, Bill O’Connor THEOLOGY Preaching the Trinity, Roderick T. Leupp PASTORAL CARE A Strategy for Counseling Couples Cohabiting Before Marriage, Don Weston; Counseling the Suffering: Seven Ways to Help Hurting People, Victor M. Parachin; A Handful of Lock Washers, Stephen W. Nease PASTOR’S PROFESSIONAL GROWTH Leading People, Clyde M. Hughes PASTOR’S PERSONAL GROWTH Prayer-Life Crises in the Church, K. P. Yohannan; Confession of a Sinking Preacher, Alan Redpath; As Salty Today as Then—1914, Leland May SOUNDING BOARD A Personal Letter, Richard S. Taylor MINISTER’S RESOURCE LIBRARY 12 Best Books of Recent Date, Compiled by David Grosse MINISTER’S MATE A Moving Experience, Betty Thompson CHURCH ADMINISTRATION Making Church Crises Stepping-stones to Blessing, Robert E. Coleman CHURCH GROWTH Secrets of Small-Church Leadership, Ron Klassen and John Koessler STEWARDSHIP The Preretirement Years: A Time for Planning, Don Walter TODAY’S BOOKS FOR TODAY’S PREACHERS WORSHIP AND PREACHING HELPS, James W. Tharp PICTURE WINDOWS FOR PREACHING, Compiled by Derl G. Keefer HIGHPOINT, B. W. Hambrickhttps://digitalcommons.olivet.edu/cotn_pm/1683/thumbnail.jp

Preacher\u27s Magazine Volume 72 Number 02

EDITORIAL Thanks to an Old Friend and Welcome to a New Feature, Randal E. Denny FEATURE Judgment, She Wrote, Wesley D. Tracy; How Pastors Can Bring Unity, Robert Moeller PREACHING Preach, Pastor!, Harold R. Crosser; Stump Preaching, Frank Eifert CHRISTIAN HOLIDAYS Caesar or Christ?, C. S. Cowles; The Word Became Flesh: A Christmas Reading, Peter A. Samuelson; Christmas Reminds Us Babies Are Important, Morris Chalfant; Senior Ornaments on Our Tree, J. Grant Swank Jr. PASTOR, BE ENCOURAGED The Barren Times, C. Neil Strait CHRISTIAN MINISTRY Public Ministry, Private Pain, Bill O’Connor THEOLOGY Preaching the Trinity, Roderick T. Leupp PASTORAL CARE A Strategy for Counseling Couples Cohabiting Before Marriage, Don Weston; Counseling the Suffering: Seven Ways to Help Hurting People, Victor M. Parachin; A Handful of Lock Washers, Stephen W. Nease PASTOR’S PROFESSIONAL GROWTH Leading People, Clyde M. Hughes PASTOR’S PERSONAL GROWTH Prayer-Life Crises in the Church, K. P. Yohannan; Confession of a Sinking Preacher, Alan Redpath; As Salty Today as Then—1914, Leland May SOUNDING BOARD A Personal Letter, Richard S. Taylor MINISTER’S RESOURCE LIBRARY 12 Best Books of Recent Date, Compiled by David Grosse MINISTER’S MATE A Moving Experience, Betty Thompson CHURCH ADMINISTRATION Making Church Crises Stepping-stones to Blessing, Robert E. Coleman CHURCH GROWTH Secrets of Small-Church Leadership, Ron Klassen and John Koessler STEWARDSHIP The Preretirement Years: A Time for Planning, Don Walter TODAY’S BOOKS FOR TODAY’S PREACHERS WORSHIP AND PREACHING HELPS, James W. Tharp PICTURE WINDOWS FOR PREACHING, Compiled by Derl G. Keefer HIGHPOINT, B. W. Hambrickhttps://digitalcommons.olivet.edu/cotn_pm/1683/thumbnail.jp

Characterizing the gut microbiota during plasmodium infection and antimalarial treatment.

Plasmodium, the parasitic cause of malaria, is a global pathogen, annually causing 216 million infections and 445,000 deaths. As drug resistance continues develop and no effective vaccine is available, it is critical to understand the factors underlying the severity of this disease. Plasmodium is an extra-gastrointestinal tract infection where the parasite infects red blood cells causing clinical malaria. However, recent publications have pointed to interactions between the gut microbiota and malaria. With this in mind, the role of the gut microbiota in malaria infection was studied. C57BL/6 mice from different vendors displayed differential resistance and susceptibility to severe malaria, and cecal contents transplanted from these mice to germ-free mice recapitulated the observed phenotypes. Similarly, resistant mice possessed a much more robust humoral immune response than susceptible mice, which is critical for Plasmodium clearance. When the cecal contents from resistant and susceptible mice were sequenced, Lactobacillus and Bifidobacterium genera were enriched in resistant mice. Moreover, treating susceptible mice with probiotics containing these bacterial genera after antibiotic administration led to a lower parasite burden. These observations point to a previously unknown role for the microbiota in modulating the severity of malaria. To further characterize the interactions between the host and gut microbiota in malaria, different components of gut homeostasis were investigated in both mild and severe disease. While intestinal permeability increased in both resistant and susceptible mice, there were no significant differences between the two groups. However, susceptible mice were shown to have greater numbers of lamina propria immune cells as well as greater abundances of cecal metabolites and bile acids during infection compared to resistant mice. Consistent with the decreased abundance of bile acids, histology showed much greater and prolonged damage and hemozoin deposition in the livers of susceptible mice compared to resistant mice. Despite these differences, the microbiota composition of resistant and susceptible mice became more similar during infection, although these changes were not associated with susceptibility or resistance when the altered cecal contents were transferred into germ-free mice. However, there were distinct differences in the functional capacity of the resistant and susceptible microbiota during infection. Susceptible mice showed significant increases in genes related to bacterial motility and flagellar assembly. Overall, there are profound differences in gut homeostasis during severe and mild Py infection. Finally, it was investigated whether antimalarial drugs, particularly clinically relevant artemisinin combination therapies (ACTs), could disrupt the gut microbiota. As previously shown, the composition of the gut microbiota alone can modulate the severity of Py infection; if ACTs change the microbiota composition, future infections could be more severe. To test this hypothesis, two common ACTs, artesunate plus amodiaquine and artemether plus lumefantrine, were used to orally treat mice while fecal pellets were collected to characterize the gut microbiota before and after treatment. After either ACT treatment, the overall species abundance in mice was similar to baseline. While alpha diversity remained unchanged by any treatment, there were minor, inconsistent changes in beta diversity that returned to baseline. With these findings, it does not appear that ACTs change the gut microbiota. This work has greatly increased the scientific knowledge concerning the three-fold interaction between host, gut microbiota, and Plasmodium. While much work still needs to be done, these findings can provide a contextual foundation on which future work can be built

Labor Law

Covers cases on the jurisdictional conflict between state courts and the National Labor Relations Board

Documentation of the Analyses of the Benefits and Costs of Aeronautical Research and Technology models (ABC-ART). Volume 2: Appendices

Fleet variables are defined, and source codes for each module are presented

Documentation of the analysis of the benefits and costs of aeronautical research and technology models, volume 1

The analysis of the benefits and costs of aeronautical research and technology (ABC-ART) models are documented. These models were developed by NASA for use in analyzing the economic feasibility of applying advanced aeronautical technology to future civil aircraft. The methodology is composed of three major modules: fleet accounting module, airframe manufacturing module, and air carrier module. The fleet accounting module is used to estimate the number of new aircraft required as a function of time to meet demand. This estimation is based primarily upon the expected retirement age of existing aircraft and the expected change in revenue passenger miles demanded. Fuel consumption estimates are also generated by this module. The airframe manufacturer module is used to analyze the feasibility of the manufacturing the new aircraft demanded. The module includes logic for production scheduling and estimating manufacturing costs. For a series of aircraft selling prices, a cash flow analysis is performed and a rate of return on investment is calculated. The air carrier module provides a tool for analyzing the financial feasibility of an airline purchasing and operating the new aircraft. This module includes a methodology for computing the air carrier direct and indirect operating costs, performing a cash flow analysis, and estimating the internal rate of return on investment for a set of aircraft purchase prices