Analisa Spasial Kerawanan Bencana Tsunami Di Wilayah Pesisir Kabupaten Kulon Progodaerah Istimewa YOGYAKARTA

Salah satu ancaman bencana yang ada di Indonesia adalah bahaya geologis berupa gempa bumi dan tsunami. Tsunami merupakan bencana alam yang belum dapat diperediksi kapan dan dimana terjadinya. Penelitian ini bertujuan untuk mengetahui dan memetakan daerah yang rawan bencana tsunami wilayah Pesisir Kabupaten Kulon Progo.Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dimana pengambilan lokasi titik penelitian dilakukan secara random dan analisa data yang dilakukan bertujuan untuk menguji hipotesis yang sudah ada. Pengolahan data dilakukan dengan analisis daerah rawan tsunami berdasarkan parameter yang mempengaruhi, dan penentuan daerah rawan tsunami. Proses pemodelan melalui proses pembobotan dan skoring parameter yang berpengaruh kemudian ditumpang susunkan untuk mendapatkan peta kerawanan bencana tsunami. Melalui analisis dan pemodelan SIG, dapat diketahui wilayah pesisir Kabupaten Kulon Progo dalam kelas kerawanan tsunami dan dapat diketahui nilai luas dan persentase luas dalam tingkat kerawanan tsunami dimana kelas sangat rawan 475, 30 Ha (4,21%), kelas rawan 3621, 98 (32,10%), kelas agak rawan 2441, 24 Ha ( 21,63%), kelas aman 3316, 03 Ha (29,38%), dan kelas sangat aman 1430, 85 (12,68%)

State of Florida Division of Administrative Hearings: Fourth Motion to Dismiss

Legal documents related to a dispute between the Sawmill Slough Conservation Club vs. the University of North Floridahttps://digitalcommons.unf.edu/sawmill_history/1020/thumbnail.jp

Using the Gene Ontology to Annotate Key Players in Parkinson's Disease

The Gene Ontology (GO) is widely recognised as the gold standard bioinformatics resource for summarizing functional knowledge of gene products in a consistent and computable, information-rich language. GO describes cellular and organismal processes across all species, yet until now there has been a considerable gene annotation deficit within the neurological and immunological domains, both of which are relevant to Parkinson's disease. Here we introduce the Parkinson's disease GO Annotation Project, funded by Parkinson's UK and supported by the GO Consortium, which is addressing this deficit by providing GO annotation to Parkinson's-relevant human gene products, principally through expert literature curation. We discuss the steps taken to prioritise proteins, publications and cellular processes for annotation, examples of how GO annotations capture Parkinson's-relevant information, and the advantages that a topic-focused annotation approach offers to users. Building on the existing GO resource, this project collates a vast amount of Parkinson's-relevant literature into a set of high-quality annotations to be utilized by the research community

Material Peredam Suara Dengan Menggunakan Kombinasi Damen, Serabut Kelapa, Dan Dinding Bata

Penelitian dilakukan dengan menguji model benda uji di dalam Universitas Kristen Petra, Laboratorium Akustik, Gedung J.101. Model benda uji diberi sumber bunyi yang kemudian diukur perbedaan suara di dalam dan di luar model benda uji dalam satuan desibel (dB) menggunakan alat sound meter. Penelitian ini bertujuan untuk membandingkan efektivitas dari berbagai macam insulasi suara serta memperkaya pilihan kontraktor akan variasi peredam suara. Tipeinsulasi yang ditinjauadalah berbagai macam komposisi campuran dan kombinasi campuran. Pada penelitian ini, dinding yang terbuat dari campuran semen, pasir, dengan 5% volume kombinasi damen dan serabut kelapa dengan dinding bata. Terdapat 3 macam kombinasi, yaitu: 30% damen dan 70% serabut kelapa, 50% damen dan 50% serabut kelapa, dan 70% damen dan 30% serabut kelapa. Komposisi campuran beton menggunakan 2 macam, yaitu: 1 pc : 2 ps dan 1 pc : 3 ps. Kesimpulan yang didapat bahwa tiap macam insulasi memiliki kelebihan dan kekurangan tersendiri dari sisi efektivitas, ekonomis, dan penerapan di lapangan

Supporting User-Defined Functions on Uncertain Data

Uncertain data management has become crucial in many sensing and scientific applications. As user-defined functions (UDFs) become widely used in these applications, an important task is to capture result uncertainty for queries that evaluate UDFs on uncertain data. In this work, we provide a general framework for supporting UDFs on uncertain data. Specifically, we propose a learning approach based on Gaussian processes (GPs) to compute approximate output distributions of a UDF when evaluated on uncertain input, with guaranteed error bounds. We also devise an online algorithm to compute such output distributions, which employs a suite of optimizations to improve accuracy and performance. Our evaluation using both real-world and synthetic functions shows that our proposed GP approach can outperform the state-of-the-art sampling approach with up to two orders of magnitude improvement for a variety of UDFs. 1

Pelatihan Pembuatan Cendera Mata untuk Persiapan Entrepreneur Baru bagi Ibu-Ibu PKK di RW 10 Kel. Lesanpuro, Kec. Kedungkandang, Kota Malang

Warga RT. 07 RW. 10 Kel. Lesanpuro, Kec. Kedungkandang, Kota Malang dengan jumlah warga sekitar 30 KK, sebagian besar ibu-ibu PKK memiliki waktu yang senggang untuk melakukan kegiatan yang produktif dan diharapkan dapat menambah pendapatan harian. Secara subjektif para ibu-ibu rumah tangga mengeluarkan anggaran belanja harian yang relatif meningkat yang tidak dapat dihindarkan karena inflasi, walaupun relatif masih rendah, harga bahan pokok seperti sembako. Pelatihan pembuatan cendera mata yang sedang laku dan memiliki banyak permintaan di pasaran dilakukan oleh ibu-ibu PKK dalam rangka persiapan entrepreneur baru. Adapun pelatih untuk membuat cendera mata adalah pelatih yang sudah berpengalaman di bidang pembuatan cendera mata dari pernik-pernik dan clay. Jumlah peserta meningkat dari sepuluh orang menjadi 30 orang ibu-ibu PKK. Metode yang digunakan adalah Project Based-Learning, yakni pelatihan dengan metode teori dan langsung praktik. Keluaran dari kegiatan pengabdian masyarakat ini adalah publikasi media elektronik, dan publikasi video. Para peserta sangat antusias untuk mengikuti kegiatan ini. Kegiatan membuat cendera mata ini belum pernah dilakukan, sehingga merupakan hal baru dan diharapkan dapat dipasarkan dengan harga memadai bagi para turis domestik maupun manca negara dan acara perhelatan

Yield stress, heterogeneities and activated processes in soft glassy materials

The rheological behavior of soft glassy materials basically results from the interplay between shearing forces and an intrinsic slow dynamics. This competition can be described by a microscopic theory, which can be viewed as a nonequilibrium schematic mode-coupling theory. This statistical mechanics approach to rheology results in a series of detailed theoretical predictions, some of which still awaiting for their experimental verification. We present new, preliminary, results about the description of yield stress, flow heterogeneities and activated processes within this theoretical framework.Comment: Paper presented at "III Workshop on Non Equilibrium Phenomena...", Pisa 22-27 Sep. 200

Youth Gambling: The health and wellbeing of New Zealand secondary school students in 2012

Gambling has become a widely available activity in today’s society (Hardoon & Derevensky, 2002; Turchi & Derevensky, 2006). In fact, many researchers “have noted that an entire generation has now grown up in an era when lottery and casino gambling is widely available and heavily advertised” (Volberg, Gupta, Griffiths, Ólason, & Delfabbro, 2010, p. 3). Evidence suggests that it has become a popular past-time not only for adults, but also for children and young people (Derevensky & Gupta, 2000; Gupta & Derevensky, 1998a; Hardoon & Derevensky, 2002; Jacobs, 2000; Splevins, Mireskandari, Clayton, & Blaszczynski, 2010; Turchi & Derevensky, 2006). Moreover, research indicates that gambling is one of the first risky activities that adolescents become involved with (i.e. they begin gambling prior to experimentation with alcohol, drugs, sexual behaviour) (Volberg, et al., 2010). Whilst for many youth involvement in gambling does not result in problematic behaviour, others go on to experience serious problems (Dickson, Derevensky, & Gupta, 2003). A vast range of adolescent gambling prevalence studies that have been undertaken over the past 25 years, across different countries, and incorporating general populations as well as youth specifically. Rates of youth problem gambling have often been found to be higher than the rates identified for adults (Huang & Boyer, 2007; Shaffer & Hall, 1996; Welte, Barnes, Tidwell, & Hoffman, 2008; Williams, Page, Parke, & Rigbye, 2008), with some estimating them to be more than double those of adults (Gupta & Derevensky, 1998a; Jackson, Dowling, Thomas, Bond, & Patton, 2008; Lesieur, et al., 1991), or up to three times as high (Rigbye, 2010). However, it has also been recognised that there is far less research in this field compared to that which has explored other youth risk behaviours such as substance use (Blinn-Pike, Worthy, & Jonkman, 2010). The gap in New Zealand-based information regarding prevalence of youth gambling has been identified previously (Bellringer, et al., 2003; Rossen, Tse, & Vaidya, 2009) and in 2003 it was recommended that research be undertaken to measure the involvement of New Zealand youth in gambling as well as associated factors and gambling-related problems (Bellringer, et al., 2003). A limited body of research has since employed various sources of data to consider youth gambling in New Zealand (e.g. Gray, 2010; Ministry of Health, 2008, 2009; Rossen, 2008; Rossen, Butler, & Denny, 2011). An extremely valuable source of information on New Zealand youth is the University of Auckland’s (UoA) National youth health and wellbeing surveys. To date, the UoA’s Adolescent Health Research Group (AHRG) has completed three National youth health and wellbeing surveys. The Youth2000 Survey Series aim to provide nationally representative information on the health and wellbeing of young people attending New Zealand secondary schools. The Survey Series includes a wide range of questions about issues that contribute to the health and wellbeing of young people (such as substance use, injuries and violence, home and family) and allow researchers to take an ecological approach to identifying overall risk and protective factors in young people’s lives. Youth’12, a survey of 8,500 secondary school students throughout New Zealand, is the most recent survey to be undertaken by the AHRG. The inclusion of gambling items in the Youth’12 survey provides a unique opportunity to examine the impacts of gambling and problem gambling on secondary school students throughout New Zealand within an ecological framework. This report was commissioned by the Ministry of Health and begins with a comprehensive review of the local and international youth gambling literature, followed by an overview of the Youth2000 Survey Series and methodology for Youth’12. A thorough analysis of Youth’12 gambling items was undertaken with results being reported under the following eight categories (detailed results for each set of analyses are also provided in the appendices): - Students and their own gambling (Section Five); - Unhealthy gambling amongst students (Section Six); - Attitudes and motivating factors towards gambling (Section Seven); - The impacts of others’ gambling on students (Section Eight); and, - Risk and protective factors for student gambling (Section Nine); - Gambling and Māori taitamariki in Aotearoa (Section 10); - Gambling and Pacific young people in New Zealand (Section 11); and, - Gambling and Asian young people in New Zealand (Section 12). Finally, a discussion chapter provides an overview of the findings and implications

Bioactive fraction of geopropolis from Melipona scutellaris decreases neutrophils migration in the inflammatory process: involvement of nitric oxide pathway

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOThe aim of this study was to evaluate the activity of the ethanolic extract of geopropolis (EEGP) from Melipona scutellaris and its fractions on the modulation of neutrophil migration in the inflammatory process, and the participation of nitric oxide (NO) pathway, as well as to check the chemical profile of the bioactive fraction. EEGP and its aqueous fraction decreased neutrophil migration in the peritoneal cavity and also the interaction of leukocytes (rolling and adhesion) with endothelial cells. The levels of chemokines CXCL1/KC and CXCL2/MIP-2 were not altered after treatment with EEGP and the aqueous fraction. It was found that the injection of NO pathway antagonists abolished the EEGP and the aqueous fraction inhibitory activity on the neutrophil migration. The expression of intercellular adhesion molecule type 1 (ICAM-1) was reduced, and nitrite levels increased after treatment with EEGP and aqueous fraction. In the carrageenan-induced paw edema model, EEGP and the aqueous fraction showed antiedema activity. No pattern of flavonoid and phenolic acid commonly found in propolis samples of Apis mellifera could be detected in the aqueous fraction samples. These data indicate that the aqueous fraction found has promising bioactive substances with anti-inflammatory activity2013FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP [2009/12352-3, 2010/20214-7]2009/12352-3; 2010/20214-

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53.

The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor response is also dependent on wild-type p53. Novel 3-(2-anilinoethyl)-substituted imidazotetrazines are reported that have activity independent of MGMT, MMR and p53. This is achieved through a switch of mechanism so that bioactivity derives from imidazotetrazine-generated arylaziridinium ions that principally modify guanine-N7 sites on DNA. Mono- and bi-functional analogs are reported and a quantitative structure-activity relationship (QSAR) study identified the p-tolyl-substituted bi-functional congener as optimized for potency, MGMT-independence and MMR-independence. NCI60 data show the tumor cell response is distinct from other imidazotetrazines and DNA-guanine-N7 active agents such as nitrogen mustards and cisplatin. The new imidazotetrazine compounds are promising agents for further development and their improved in vitro activity validates the principles on which they were designed