Closing Thoughts on “Information Systems Research: Thinking Outside the Basket and Beyond the Journal”

This essay provides a rejoinder by the original authors to the set of responses to Fitzgerald, B., Dennis, A. R., An, J., Tsutsui, S., & Muchala, R. C. (2019). Information systems research: Thinking outside the basket and beyond the journal. Communications of the Association for Information Systems, 45, 110-133

Sensitivity Analysis of Optimum Tutor Staffing Schedule using Discrete Event Simulation

This study utilized the discrete-event simulation (DES) approach to optimize the daily tutor cost for the Unified Tutoring Center, located at the Daytona Beach campus of Embry-Riddle Aeronautical University. The simulation model was built using Arena version 12, and the objective of the study was to determine an optimum tutor staffing schedule to reduce operating costs, while also servicing as many students as possible and with the students experiencing a minimal wait time. Data was collected by videotaping four weeks (or 20 nights) worth of evening tutoring sessions. Two models, the General Study Room and the Physics & Chemistry Lab, were validated by comparing the observed tutor utilization with the model’s output utilization. A sensitivity analysis was conducted on both models based on average waiting time, maximum waiting time and maximum tutor utilization. A more practical tutor staffing schedule was found for the General Study Room and the Physics & Chemistry Lab, yielding an overall decrease in the weekly operational cost of tutors by $178.50

Measuring Organization of Large Surficial Clasts in Heterogeneous Gravel Beach Sediments

The natural stratification and interlocking “organization” of armored sediments in heterogeneous, coarse-grained, beaches provides protection and enhances habitat for borrowing sedentary megafauna and macrofauna such as hard-shelled clams. Here, we develop a novel metric for quantifying sediment organization of large surficial beach clasts through sedimentologic and photogrammetric analyses of 37 lower intertidal heterogeneous gravel beaches in western Prince William Sound, Alaska (USA). Grain size, photogrammetric, and Wolman Pebble Count clast-size data from 64, ~1-m2 study plots are combined into a clast-size-independent “Organization Metric” to quantify the degree of organization in the meshed arrangement of larger surficial sediments. This metric was validated through field manipulation experiments and comparisons of adjacent plots characterized by different clast sizes. Application of this metric to subsets of Prince William Sound beaches that underwent differential treatment following the Exxon Valdez oil spill reveals persistent physical effects of artificial beach disturbance even 21 years after the cleanup. This has important implications for beach management (e.g., cleaning or dredging) and for the diverse and productive sedentary megafaunal assemblages that live within these sediments. Overall, this study provides a new approach for quantifying organization of heterogenous coarse sediments in diverse natural settings; in particular, heterogenous gravel beaches

Use of Immersive Virtual Reality in the Assessment and Treatment of Alzheimer's Disease: A Systematic Review.

BACKGROUND: Immersive virtual reality (iVR) allows seamless interaction with simulated environments and is becoming an established tool in clinical research. It is unclear whether iVR is acceptable to people with Alzheimer's disease (AD) dementia or useful in their care. We explore whether iVR is a viable research tool that may aid the detection and treatment of AD. OBJECTIVES: This review examines the use of iVR in people with AD or mild cognitive impairment (MCI). METHODS: Medline, PsycINFO, Embase, CINAHL, and Web of Science databases were searched from inception. PRISMA guidelines were used with studies selected by at least two researchers. RESULTS: Nine studies were eligible for inclusion. None reported any issues with iVR tolerability in participants with MCI and AD on assessment or treatment tasks. One study demonstrated capability for detecting prodromal AD and correlated with neuroanatomical substrates. Two studies showed iVR to have high accuracy in differentiating participants with AD from controls but were not hypothesis driven or with adequate controls measures. In a small validation study and two longitudinal case studies, iVR cognitive training was positively rated but did not demonstrate reliable benefit. CONCLUSION: iVR is emerging as a viable method of assessing older adults and people with AD. Strongest benefits were seen when closely integrated with theoretical models of neurodegeneration and existing screening methods. Further randomized controlled trials integrated with clinical populations are required. This will consolidate the power of iVR for assessment of MCI and clarify treatment efficacy beyond current applications in physical rehabilitation

Effect of Sedentary and Physical Activities on Children’s Food Choice

International Journal of Exercise Science 10(5): 702-712, 2017. Childhood obesity is a growing public health concern. Research has shown sedentary behavior (SB) increases children’s unhealthy food consumption, while physical activity (PA) decreases caloric intake and increases energy expenditure. The purpose of this study was to examine child snack choice following a bout of active, SB, and a mix of SB and active (SB-A). Participants included a volunteer sample of children (n=24) ranging from 9-13 years of age. A within-subjects simple experimental design was used, and children participated in three conditions: active, SB, and SB-A. After each condition, the children were asked to choose one snack from two healthy and two unhealthy options. The children were randomized into one of the six possible condition sequences (4 children per group) based on when they enrolled in the study. Data were analyzed in SPSS (v21) using the Friedman, Wilcoxon Signed-Rank, and Kruskal-Wallis tests. There was not a statistically significant difference in the overall model comparing the three conditions on snack choice (p=0.15). Overweight/obese children were significantly more likely than normal weight children to choose a healthier snack option after the active condition (p=0.02). There was no difference between boys and girls for snack choice following the active (p\u3e0.05), SB (p\u3e0.05), and SB-A (p\u3e0.05). Our overall findings suggest SB and active had no effect on children’s snack choice. Promoting PA to children who are overweight/obese could lead to decreased energy intake and increased energy expenditure combating the obesity epidemic

Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand

Although the mechanisms for sustained chemokine gradients and recurring cell infiltration in sterile peritonitis have not been elucidated, toll-like receptors (TLRs) have been implicated. To abate the deleterious recruitment of neutrophils in sterile inflammation, we repeatedly administered a TLR7 ligand that hyposensitized to TLR7 and receptors that converged on the MyD88-signaling intermediary and reduced cellular infiltration in murine autoimmune models of multiple sclerosis and arthritis. To reduce potential adverse effects, a polyethylene glycol polymer was covalently attached to the parent compound (Tolerimod1). The proinflammatory potency of Tolerimod1 was 10-fold less than the unconjugated TLR7 ligand, and Tolerimod1 reduced neutrophil recruitment in chemically induced peritonitis and colitis. The effects of Tolerimod1 were mediated by the radioresistant cells in radiation chimeric mice and by mast cells in reconstituted mast cell-deficient mice (KitW-sh). Although the Tolerimod1 had weak proinflammatory agonist activity, it effectively reduced neutrophil recruitment in sterile peritoneal inflammation

Personality Goes a Long a Way: An Interhemispheric Connectivity Study

Throughout the development of psychology the delineation of personality has played a central role. Together with the NEO-PI-R, a questionnaire derived from the Five Factor Model of Personality, and recent advances in research technology it is now possible to investigate the relationship between personality features and neurophysiological brain processes. The NEO-FFI, the short version of the NEO-PI-R, reliably measures five main personality traits: Neuroticism, Extraversion, Openness to experience, Agreeableness, and Conscientiousness. As behavior and some psychiatric disorders have been related to interhemispheric connectivity, the present study used the combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to measure frontal interhemispheric connectivity and its association with personality as indexed by the NEO-FFI. Results demonstrated that prefrontal interhemispheric connectivity between the left and right dorsolateral prefrontal cortex correlates with Agreeableness in healthy subjects. This is the first study to relate personality features to interhemispheric connectivity through TMS–EEG and suggests that Agreeableness relates to the effectiveness of prefrontal communication between hemispheres

IKKα negatively regulates ASC-dependent inflammasome activation.

The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report that IκB kinase α (IKKα) is a critical negative regulator of apoptosis-associated specklike protein containing a C-terminal caspase-activation-andrecruitment (CARD) domain (ASC)-dependent inflammasomes. IKKα controls the inflammasome at the level of the adaptor ASC, which interacts with IKKα in the nucleus of resting macrophages in an IKKα kinase-dependent manner. Loss of IKKα kinase activity results in inflammasome hyperactivation. Mechanistically, the downstream nuclear effector IKK-related kinase (IKKi) facilitates translocation of ASC from the nucleus to the perinuclear area during inflammasome activation. ASC remains under the control of IKKα in the perinuclear area following translocation of the ASC/IKKα complex. Signal 2 of NLRP3 activation leads to inhibition of IKKα kinase activity through the recruitment of PP2A, allowing ASC to participate in NLRP3 inflammasome assembly. Taken together, these findings reveal a IKKi-IKKα-ASC axis that serves as a common regulatory mechanism for ASC-dependent inflammasomes

Key Data Gaps for Understanding Trends in Prescription Opioid Analgesic Abuse and Diversion Among Chronic Pain Patients and Nonmedical Users

Population dynamics of medical and nonmedical prescription opioid usage and adverse outcomes were modeled. Critical parameter values were determined by their amount of influence on model behavior. Results suggest that closing these data gaps would help researchers to better identify ways to reduce the risk of adverse outcomes