Immersive learning research

Editorial. Material for the special issue "Immersive Learning Research" of the Journal of Universal Computer Science.Welcome to the Journal of Universal Computer Science (J.UCS) special issue organized by the Immersive Learning Research Network (iLRN) following the 2017 iLRN conference. This issue includes eight papers on the focused topic "Immersive Learning Research", including extended versions of papers presented at iLRN 2017 and articles from the public call for papers.info:eu-repo/semantics/publishedVersio

The Case of the Off-Center, Levitating Bar in the Large Magellanic Cloud

I explore the hypothesis that many of the unusual aspects of the apparent stellar bar of the Large Magellanic Cloud are the result of viewing a triaxial stellar bulge that is embedded in a highly obscuring thin disk. Specifically, this hypothesis explains the observed off-center position of the bar within the disk, the differing apparent distances of the bar and disk, the near alignment of the bar's major axis position angle and the disk's line-of-nodes, and the asymmetric appearance of the bar itself. Indirectly, it may also play a role in explaining the microlensing rate toward the LMC and the recently observed large velocity dispersion of RR Lyrae stars.Comment: 5 emulateapj style pages, accepted for publication in ApJ

Using hoops structures for gestation or breeding barns

Dr. Danny Burns, who has operated a veterinary practice the past 23 years, also has been part of a farm partnership for 10 years. He and his partner now have about 650 sows, in addition to a row crop operation. Dean Ekstrom has a 90-sow farrow-tofinish operation in Webster County. He also was named a 1997 Master Pork Producer

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal of the symposium was to highlight recent advances and developments in the field of alcohol and nutrition. The symposium was focused on experimental and clinical aspects in relation to the role of different types of dietary nutrients and malnutrition in the pathogenesis of alcoholic liver disease (ALD). The following is a summary of key research presented at this session. The speakers discussed the role of dietary fats and carbohydrates in the development and progression of alcohol-induced multi-organ pathology in animal models of ALD, analyzed novel nutrition-related therapeutics (specifically, betaine and zinc) in the treatment of ALD, and addressed clinical relevance of malnutrition and nutrition support in ALD. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows

Size Estimates of the Extinct Marine Snake Pterosphenus schucherti from Eocene-aged Sediments of Central Georgia

Fossil snakes are most often identified from isolated vertebrae, complicating estimations of total body lengths of extinct taxa. Here we estimate the range of total body length of the late Eocene North American palaeophiid marine snake Pterosphenus schucherti based on 29 recently collected fossil vertebrae from Wilkinson County, Georgia, USA. Previous research suggests that the palaeophiids are most closely related to modern boids. Total body length estimates here are based on family-specific regressions of centrum length versus known total body length in extant members of Boidae, Pythonidae, and Colubridae. The high correlation coefficients for the family specific regressions supports previous studies that used centrum length to estimate total body length in extinct snakes. Here, size estimates for Pterosphenus schucherti ranged from 2.5 to 4.8 m using boids, 3.4 to 13.0 m using pythonids, and 2.8 to 5.3 m using colubrids. This study demonstrates how the lumping of multiple extant clades greatly increases the range of variability for length estimations. For the TL estimates of fossil snakes, it appears that regressions generated from the lowest taxonomic level of the most closely related extant species should be used

Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing.

Recent efforts to comprehensively characterize great ape genetic diversity using short-read sequencing and single-nucleotide variants have led to important discoveries related to selection within species, demographic history, and lineage-specific traits. Structural variants (SVs), including deletions and inversions, comprise a larger proportion of genetic differences between and within species, making them an important yet understudied source of trait divergence. Here, we used a combination of long-read and -range sequencing approaches to characterize the structural variant landscape of two additional Pan troglodytes verus individuals, one of whom carries 13% admixture from Pan troglodytes troglodytes. We performed optical mapping of both individuals followed by nanopore sequencing of one individual. Filtering for larger variants (>10 kbp) and combined with genotyping of SVs using short-read data from the Great Ape Genome Project, we identified 425 deletions and 59 inversions, of which 88 and 36, respectively, were novel. Compared with gene expression in humans, we found a significant enrichment of chimpanzee genes with differential expression in lymphoblastoid cell lines and induced pluripotent stem cells, both within deletions and near inversion breakpoints. We examined chromatin-conformation maps from human and chimpanzee using these same cell types and observed alterations in genomic interactions at SV breakpoints. Finally, we focused on 56 genes impacted by SVs in >90% of chimpanzees and absent in humans and gorillas, which may contribute to chimpanzee-specific features. Sequencing a greater set of individuals from diverse subspecies will be critical to establish the complete landscape of genetic variation in chimpanzees

The Role of Tumor Necrosis Factor Associated Factors (TRAFs) in Vascular Inflammation and Atherosclerosis

TNF receptor associated factors (TRAFs) represent a family of cytoplasmic signaling adaptor proteins that regulate, bundle, and transduce inflammatory signals downstream of TNF- (TNF-Rs), interleukin (IL)-1-, Toll-like- (TLRs), and IL-17 receptors. TRAFs play a pivotal role in regulating cell survival and immune cell function and are fundamental regulators of acute and chronic inflammation. Lately, the inhibition of inflammation by anti-cytokine therapy has emerged as novel treatment strategy in patients with atherosclerosis. Likewise, growing evidence from preclinical experiments proposes TRAFs as potent modulators of inflammation in atherosclerosis and vascular inflammation. Yet, TRAFs show a highly complex interplay between different TRAF-family members with partially opposing and overlapping functions that are determined by the level of cellular expression, concomitant signaling events, and the context of the disease. Therefore, inhibition of specific TRAFs may be beneficial in one condition and harmful in others. Here, we carefully discuss the cellular expression and signaling events of TRAFs and evaluate their role in vascular inflammation and atherosclerosis. We also highlight metabolic effects of TRAFs and discuss the development of TRAF-based therapeutics in the future.Fil: Gissler, Mark Colin. Albert Ludwigs University of Freiburg; AlemaniaFil: Stachon, Peter. Albert Ludwigs University of Freiburg; AlemaniaFil: Wolf, Dennis. Albert Ludwigs University of Freiburg; AlemaniaFil: Marchini, Timoteo Oscar. Albert Ludwigs University of Freiburg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentin