Evalution of endogenous intoxication in patients on herpesassociated multiforme exudative erythema

In this work the determination of the parameters of endogenous intoxication in patients herpes associated multiforme exudative erythema in the context of the severity of the disease compared with patients with exudative erythema multiforme other etiologies and patients with recurrent herpes simplex. Shown that patients herpes associated multiform exudative erythema of the oral cavity have a pronounced degree of endogenous intoxication, which is directly correlated with the degree of severity of the disease, which gives grounds for inclusion in the scheme of complex treatment of patients with herpeszoster bahatoformatne exudative erythema methods of detoxication therapy

Management of wastewater from landfill of inorganic fiberglass

ArticleSustainability is one of the key factors in smart environment management and include the reduction of environment footprint. The waste and wastewater management plans are aimed on actions to reduce the amount of waste and environmental pollution. This includes collection of waste, logistics, storage, processing or valorisation and also treatment. The aim of this research was to evaluate environmental pollution risk and to demonstrate one of the wastewater management schemes to reduce the pollution level. Evaluation of the better management scheme was performed in one of the landfills in Latvia, where fiberglass waste and other inorganic waste is stored. Onsite evaluation results demonstrated the need to develop a better wastewater management scheme of inorganic fiberglass landfill. After that, laboratory–scale experiments for conventional coagulation and biodegradation tests have been performed for efficient management

Heterogeneity of population of microorganisms grown in presence of iron oxide maghemite nanoparticles

In this work γ-Fe2O3 MNPs were obtained by laser target evaporation and water based suspensions were prepared. Maximum permissive dose of iron in water (MPD) is 0.3 mg/L. It was found that 100 MPD dose of iron induces formation of non-typical colonies after 72 or 96 hours exposition: against a background of small black colonies large white colonies appeared due to a disruption in tyrosine synthesis. Multiple re-cloning of the white colonies grown with MNPs showed that they retained their properties both under standard conditions (temperature of 24 °C) and at the temperatures up to 37o C. E.nigrum grown with MNPs demonstrated very scant extension of small colonies at the cultivation temperature of 24o C, their growth was completely blocked at 37°C. Significant changes in the structure of the population were noted. First of all, large cells with pronounced aggregation were observed among the black colonies. These aggregates consisted of large cells connected to each other by matrix. In the white colonies the appearance of very long threadlike cells connecting different groups of the cells establishing an intercellular communication was evident. Fe2O3 MNPs induce an increase in the heterogeneity of the population, expressed as a change in morpho-physiological states. © 2018 The Authors, published by EDP Sciences.The work was supported by the Ministry of Education and Science of the Russian Federation (project No. 3.6121.210 )7 and R FFI №16-34-015 92 grant s. e tW hank R ndrA ade, Iu. Novoselova and I.V. Beketov for special support. Selected measurements were made at ISG KER services UPV/EHU

CLINICAL AND MORPHOLOGICAL PARRALLELS IN THE COURSE OF RESPIRATORY SARCOIDOSIS

Sarcoidosis is a systemic disease characterized by the development of chronic immune inflammation and formation of granulomas. It is important to know clinical, morphological and immunologic variants of the course of this disease in order to investigate the pathomorphologic parameters of the granuloma.Of late negative trends have been observed in the changes of sarcoidosis pathomorphology. Due to the above it is important to investigate predictors for the course of this disease, including specific parameters of granulematous inflammatory process in various clinical variants not only from the point of view of diagnostics but further management tactics for those suffering from this disease

Reasoning for obligatory preclinical diagnostics of feline chronic kidney disease

Diseases of the urinary system of various etiologies are common in all species of animals and over time, they can lead to the development of chronic kidney disease (CKD) as the progressive process in which renal function gradually decreases over several years. In modern veterinary medicine, there is a problem of a steeply increase in cases of chronic kidney disease in cats. Pathology occurs most often in aged animals, but recent studies have registered cases of chronic renal dysfunction in young ones as well. In chronic kidney disease the kidneys do not work well for a long time, causing a number of changes in the body. Unfortunately, early symptoms are often missed by pet owners and the disease is not noticed for a long time. In most cases, the diagnosis of chronic kidney disease is established only when effective treatment is no longer possible or ineffective and treatment is able to maintain the homeostasis of the body only to a certain extent and for a short time. Undoubtedly, this approach to the diagnosis and treatment of kidney disease requires changes. In view of the fact that the duration of the preclinical stage of CKD can reach several years, the goals of our study were to show the benefits of early diagnosis of chronic kidney disease in cats and the introduction of a new concept of systematic body screening of clinically healthy animals and animals at risk. Also, the goals were to delay the moment of the kidneys compensatory reserve exhaustion and onset of clinical symptoms, which require constant symptomatic and replacement therapy. Reducing the percentage of early mortality of patients and the maximum possible increase in the duration of the preclinical stage of renal pathology were also aimed at. Efforts were also aimed at reducing the percentage of early mortality of patients and the maximum possible increase in the duration of the preclinical stage of renal pathology. Since nephroprotective therapy at the preclinical stage is highly effective in most clinical cases and allows to significantly slow down the progression of any chronic nephropathy, including CKD, there is a need for the formation of innovative diagnostic approaches at the early stages of the disease. It is proposed to conduct a cumulative assessment of the anamnesis in animals from risk groups, monitoring the level of creatinine in the blood serum, complete clinical analysis of urine, ultrasound examination of the kidneys, measurement of protein concentration, since these indicators have not only prognostic value and determine the tactics of treatment, but are also important factors pathogenesis of CKD. Since each parameter will not provide a complete state of the disease, since none of them is 100 % specific, an integrated approach to the early diagnosis of chronic kidney disease is needed for. It is necessary to take into account all the methods listed above, as well as monitoring the condition of the body of animals that have contracted any viral or bacterial infection, or have acute kidney damage, diabetes, hypertension, or metabolic disorders

PRODUCTION OF ELECTRICALLY CONDUCTIVE CERAMICS BASED ON ZIRCONIUM DIOXIDE ZrO2-Y2O3-Gd2O3 AND ZrO2-Y2O3-Yb2O3

A series of ZrO2-Y2O3-Gd2O3 and ZrO2-Y2O3-Yb2O3 powders with different content of stabilizing additives has been obtained. The powders are intended for the manufacture of ce-ramic samples and the study of their electrical conductive properties

Healthcare delivery for HIV-positive people with tuberculosis in Europe

Background In a 2013 survey, we reported distinct discrepancies in delivery of tuberculosis (TB) and HIV services in eastern Europe (EE) vs. western Europe (WE). Objectives To verify the differences in TB and HIV services in EE vs. WE. Methods Twenty-three sites completed a survey in 2018 (EE, 14; WE, nine; 88% response rate). Results were compared across as well as within the two regions. When possible, results were compared with the 2013 survey. Results Delivery of healthcare was significantly less integrated in EE: provision of TB and HIV services at one site (36% in EE vs. 89% in WE; P = 0.034), and continued TB follow-up in one location (42% vs. 100%; P = 0.007). Although access to TB diagnostics, standard TB and HIV drugs was generally good, fewer sites in EE reported unlimited access to rifabutin/multi-drug-resistant TB (MDR-TB) drugs, HIV integrase inhibitors and opioid substitution therapy (OST). Compared with 2013, routine usage of GeneXpert was more common in EE in 2018 (54% vs. 92%; P = 0.073), as was access to moxifloxacin (46% vs. 91%; P = 0.033), linezolid (31% vs. 64%; P = 0.217), and bedaquiline (0% vs. 25%; P = 0.217). Integration of TB and HIV services (46% vs. 39%; P = 1.000) and provision of OST to patients with opioid dependency (54% vs. 46%; P = 0.695) remained unchanged. Conclusion Delivery of TB and HIV healthcare, including integration of TB and HIV care and access to MDR-TB drugs, still differs between WE and EE, as well as between individual EE sites

PRODUCTION OF ZIRCONIUM DIOXIDE POWDERS FOR ELECTRIC CONDUCTIVE CERAMICS

Powders ZrO2-Er2O3-Gd2O3, ZrO2-Y2O3-Sm2O3, ZrO2-Y2O3-Gd2O3 and ZrO2-Y2O3-Yb2O3 with various content of stabilizing additives are obtained, intended for the manufacture of ceramics and measurement of its electrical conductive properties

Experience of the successful treatment with canakinumab of a patient with NLPC4-associated autoinflammatory syndrome with enterocolitis

The article shows the observation of rare NLPC4-associated autoinflammatory syndrome with enterocolitis and familial cold urticaria. Diagnosis is confirmed molecularly-genetically: previously not described mutation c.928C>T in the heterozygous state in NLRC4 gene is discovered by a method of the new generation sequencing. The use of a monoclonal antibody to the interleukin 1 canakinumab provided complete relief of fever and skin and intestinal symptoms in just 1 week of treatment. Later the signs of inflammation have disappeared completely; the patient’s quality of life improved and life-threatening complications were prevented. The above example demonstrates the high clinical efficacy of canakinumab in the patient with NLRC4-associated autoinflammatory syndrome and suggests promising therapeutic use of interleukin 1 blockers in such patients. There were no adverse events during canakinumab therapy