93 research outputs found
Pressure-dependent optical investigations of -(BEDT-TTF)I: tuning charge order and narrow gap towards a Dirac semimetal
Infrared optical investigations of -(BEDT-TTF)I have been
performed in the spectral range from 80 to 8000~cm down to temperatures
as low as 10~K by applying hydrostatic pressure. In the metallic state, ~K, we observe a 50\% increase in the Drude contribution as well as the
mid-infrared band due to the growing intermolecular orbital overlap with
pressure up to 11~kbar. In the ordered state, , we extract how
the electronic charge per molecule varies with temperature and pressure:
Transport and optical studies demonstrate that charge order and metal-insulator
transition coincide and consistently yield a linear decrease of the transition
temperature by ~K/kbar. The charge disproportionation
diminishes by /kbar and the optical gap between
the bands decreases with pressure by -47~cm/kbar. In our high-pressure
and low-temperature experiments, we do observe contributions from the massive
charge carriers as well as from massless Dirac electrons to the low-frequency
optical conductivity, however, without being able to disentangle them
unambiguously.Comment: 13 pages, 17 figures, submitted to Phys. Rev.
Structure and requirement of the Spt6 SH2 domain and an in vitro system to test the âtorpedo modelâ of transcription termination
COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological subtypes, and clinical characteristics of intracranial hemorrhage (ICH) in coronavirus disease (COVID-19) patients. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the literature by screening the PubMed database and included patients diagnosed with COVID-19 and concomitant ICH. We performed a pooled analysis, including a prospectively collected cohort of critically ill COVID-19 patients with ICH, as part of the PANDEMIC registry (Pooled Analysis of Neurologic Disorders Manifesting in Intensive Care of COVID-19). Results: Our literature review revealed a total of 217 citations. After the selection process, 79 studies and a total of 477 patients were included. The median age was 58.8 years. A total of 23.3% of patients experienced the critical stage of COVID-19, 62.7% of patients were on anticoagulation and 27.5% of the patients received ECMO. The prevalence of ICH was at 0.85% and the mortality at 52.18%, respectively. Conclusion: ICH in COVID-19 patients is rare, but it has a very poor prognosis. Different subtypes of ICH seen in COVID-19, support the assumption of heterogeneous and multifaceted pathomechanisms contributing to ICH in COVID-19. Further clinical and pathophysiological investigations are warranted to resolve the conflict between thromboembolic and hemorrhagic complications in the future
The multimodal Munich Clinical Deep Phenotyping study to bridge the translational gap in severe mental illness treatment research
Introduction: Treatment of severe mental illness (SMI) symptoms, especially negative symptoms and cognitive dysfunction in schizophrenia, remains a major unmet need. There is good evidence that SMIs have a strong genetic background and are characterized by multiple biological alterations, including disturbed brain circuits and connectivity, dysregulated neuronal excitation-inhibition, disturbed dopaminergic and glutamatergic pathways, and partially dysregulated inflammatory processes. The ways in which the dysregulated signaling pathways are interconnected remains largely unknown, in part because well-characterized clinical studies on comprehensive biomaterial are lacking. Furthermore, the development of drugs to treat SMIs such as schizophrenia is limited by the use of operationalized symptom-based clusters for diagnosis.
Methods: In line with the Research Domain Criteria initiative, the Clinical Deep Phenotyping (CDP) study is using a multimodal approach to reveal the neurobiological underpinnings of clinically relevant schizophrenia subgroups by performing broad transdiagnostic clinical characterization with standardized neurocognitive assessments, multimodal neuroimaging, electrophysiological assessments, retinal investigations, and omics-based analyzes of blood and cerebrospinal fluid. Moreover, to bridge the translational gap in biological psychiatry the study includes in vitro investigations on human-induced pluripotent stem cells, which are available from a subset of participants.
Results: Here, we report on the feasibility of this multimodal approach, which has been successfully initiated in the first participants in the CDP cohort; to date, the cohort comprises over 194 individuals with SMI and 187 age and gender matched healthy controls. In addition, we describe the applied research modalities and study objectives.
Discussion: The identification of cross-diagnostic and diagnosis-specific biotype-informed subgroups of patients and the translational dissection of those subgroups may help to pave the way toward precision medicine with artificial intelligence-supported tailored interventions and treatment. This aim is particularly important in psychiatry, a field where innovation is urgently needed because specific symptom domains, such as negative symptoms and cognitive dysfunction, and treatment-resistant symptoms in general are still difficult to treat
Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study
Structure and requirement of the Spt6 SH2 domain and an in vitro system to test the âtorpedo modelâ of transcription termination.
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Das Storz-Endospine nach Destandau, ein mobiles Endoskopiesystem zur Behandlung des lumbalen Bandscheibenvorfalls und der lumbalen Stenose: erste Ergebnisse in 25 FĂ€llen
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