1,831 research outputs found
Factors affecting mortality in late stage Parkinson’s Disease
To determine the effect of dysphagia and hospital admissions on mortality in late stage Parkinson’s disease
Non-immune fetal hydrops: etiology and outcome according to gestational age at diagnosis.
OBJECTIVE: Fetal hydrops is associated with increased perinatal morbidity and mortality. The etiology and outcome of fetal hydrops may differ according to the gestational age at diagnosis. The aim of this study was to evaluate the cause, evolution and outcome of non-immune fetal hydrops (NIFH), according to the gestational age at diagnosis. METHODS: This was a retrospective cohort study of all singleton pregnancies complicated by NIFH, at the Fetal Medicine Unit at St George's University Hospital, London, UK, between 2000 and 2018. All fetuses had detailed anomaly and cardiac ultrasound scans, karyotyping and infection screening. Prenatal diagnostic and therapeutic intervention, gestational age at diagnosis and delivery, as well as pregnancy outcome, were recorded. Regression analysis was used to test for potential association between possible risk factors and perinatal mortality. RESULTS: We included 273 fetuses with NIFH. The etiology of the condition varied significantly in the three trimesters. Excluding 30 women who declined invasive testing, the cause of NIFH was defined as unknown in 62 of the remaining 243 cases (25.5%). Chromosomal aneuploidy was the most common cause of NIFH in the first trimester. It continued to be a significant etiologic factor in the second trimester, along with congenital infection. In the third trimester, the most common etiology was cardiovascular abnormality. Among the 152 (55.7%) women continuing the pregnancy, 48 (31.6%) underwent fetal intervention, including the insertion of pleuroamniotic shunts, fetal blood transfusion and thoracentesis. Fetal intervention was associated significantly with lower perinatal mortality (odds ratio (OR), 0.30 (95% CI, 0.14-0.61); P  0.05). CONCLUSIONS: An earlier gestational age at diagnosis of NIFH was associated with an increased risk of aneuploidy and worse pregnancy outcome, including a higher risk of perinatal loss. Fetal therapy was associated significantly with lower perinatal mortality. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology
Effect of isospin dependent cross-section on fragment production in the collision of charge asymmetric nuclei
To understand the role of isospin effects on fragmentation due to the
collisions of charge asymmetric nuclei, we have performed a complete
systematical study using isospin dependent quantum molecular dynamics model.
Here simulations have been carried out for , where n
varies from 47 to 59 and for , where m varies from 14
to 23. Our study shows that isospin dependent cross-section shows its influence
on fragmentation in the collision of neutron rich nuclei
Reporting on data monitoring committees in neonatal randomised controlled trials is inconsistent
Aim: To evaluate the reported use of Data Monitoring Committees (DMCs), the frequency of interim analysis, pre-specified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). Methods: We reviewed neonatal RCTs published in four high impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria. Results: Seventy neonatal trials were identified in four general medical journals: Lancet, New England Journal of Medicine (NEJM), British Medical Journal and Journal of American Medical Association (JAMA). 43 (61.4%) studies reported the presence of a DMC, 36 (51.4%) explicitly mentioned interim analysis; stopping rules were reported in 15 (21.4%) RCTs and 7 (10%) trials were terminated early. The NEJM most frequently reported these parameters compared to the other three journals reviewed. Conclusion: While the majority of neonatal RCTs report on DMC involvement and interim analysis there is still scope for improvement. Clear documentation of safety related issues should be a central component of reporting in neonatal trials involving newborn infants
Hydrodynamic theory of an electron gas
The generalised hydrodynamic theory of an electron gas, which does not rely
on an assumption of a local equilibrium, is derived as the long-wave limit of a
kinetic equation. Apart from the common hydrodynamics variables the theory
includes the tensor fields of the higher moments of the distribution function.
In contrast to the Bloch hydrodynamics, the theory leads to the correct plasmon
dispersion and in the low frequency limit recovers the Navies-Stocks
hydrodynamics. The linear approximation to the generalised hydrodynamics is
closely related to the theory of highly viscous fluids.Comment: 4 pages, revte
The Neoarchaean Uyea Gneiss Complex, Shetland: an onshore fragment of the Rae Craton on the European Plate
A tract of amphibolite facies granitic gneisses and metagabbros in northern Shetland, U.K., is here named the Uyea Gneiss Complex. Zircon U–Pb dating indicates emplacement of the igneous protoliths of the complex c. 2746–2726 Ma, at a later time than most of the Archaean protoliths of the Lewisian Gneiss Complex of mainland Scotland. Calc-alkaline geochemistry of the Uyea Gneiss Complex indicates arc-affinity and a strong genetic kinship among the mafic and felsic components. Zircon Hf compositions suggest an enriched mantle source and limited interaction with older crust during emplacement. Ductile fabrics developed soon after emplacement, with zircon rims at c. 2710 Ma, but there was little further deformation until Caledonian reworking east of the Uyea Shear Zone. There is no evidence for the Palaeoproterozoic reworking that dominates large tracts of the Lewisian Gneiss Complex and of the Nagssugtoqidian Orogen of East Greenland. The more northerly location of the Uyea Gneiss Complex and extensive offshore basement of similar age implies that, prior to the opening of the North Atlantic Ocean, these rocks were contiguous with the Archaean Rae Craton
Statistical evolution of isotope composition of nuclear fragments
Calculations within the statistical multifragmentation model show that the
neutron content of intermediate mass fragments can increase in the region of
liquid-gas phase transition in finite nuclei. The model predicts also
inhomogeneous distributions of fragments and their isospin in the freeze-out
volume caused by an angular momentum and external long-range Coulomb field.
These effects can take place in peripheral nucleus-nucleus collisions at
intermediate energies and lead to neutron-rich isotopes produced in the
midrapidity kinematic region.Comment: 14 pages with 4 figures. GSI preprint, Darmstadt, 200
Bragg resonances for tunneling between edges of a 2D Quantum Hall system
A theory is presented for tunneling between compressible regions on the sides
of a narrow incompressible Quantum Hall strip. Assuming that electron
interactions lead to formation of a Wigner crystal on the edges of the
compressible regions, we consider the situation when the non-conservation of
electron momentum required for transport is provided, in the absence of
disorder, by umklapp scattering on the crystal. The momentum given to the
crystal is quantized due to the Bragg condition, which leads to resonances in
tunneling conductivity as a function of the incompressible strip width, similar
to those reported recently by N. Zhitenev, M. Brodsky, R. Ashoori, and M.
Melloch.Comment: 4 pages RevTex, 2 figure
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