Discomfort criteria for single-axis vibrations

Experimental investigations were conducted to determine the fundamental relationships governing human subjective discomfort response to single-axis vibrations. The axes investigated were vertical, lateral, longitudinal, roll, and pitch, and the vibrations used were both sinusoidal and random in nature. Results of these investigations provided the basis for: (1) development of a scale of passenger discomfort that is common to all axes of vibration; and (2) generation of discomfort criteria for each axis of each axis and for both types of vibration. Furthermore, empirical equations describing discomfort responses within each axis of vibration are included

Ride quality meter

A ride quality meter is disclosed that automatically transforms vibration and noise measurements into a single number index of passenger discomfort. The noise measurements are converted into a noise discomfort value. The vibrations are converted into single axis discomfort values which are then converted into a combined axis discomfort value. The combined axis discomfort value is corrected for time duration and then summed with the noise discomfort value to obtain a total discomfort value

Metabolism of Nonessential N15-Labeled Amino Acids and the Measurement of Human Whole-Body Protein Synthesis Rates

Eight N-15 labeled nonessential amino acids plus (15)NH4Cl were administered over a 10 h period to four healthy adult males using a primed-constant dosage regimen. The amount of N-15 excreted in the urine and the urinary ammonia, hippuric acid, and plasma alanine N-15 enrichments were measured. There was a high degree of consistency across subjects in the ordering of the nine compounds based on the fraction of N-15 excreted (Kendall coefficient of concordance W = 0.83, P is less than 0.01). Protein synthesis rates were calculated from the urinary ammonia plateau enrichment and the cumulative excretion of N-15. Glycine was one of the few amino acids that gave similar values by both methods

Management of Mechanical Ventilation in Decompensated Heart Failure.

Mechanical ventilation (MV) is a life-saving intervention for respiratory failure, including decompensated congestive heart failure. MV can reduce ventricular preload and afterload, decrease extra-vascular lung water, and decrease the work of breathing in heart failure. The advantages of positive pressure ventilation must be balanced with potential harm from MV: volutrauma, hyperoxia-induced injury, and difficulty assessing readiness for liberation. In this review, we will focus on cardiac, pulmonary, and broader effects of MV on patients with decompensated HF, focusing on practical considerations for management and supporting evidence

The influence of correlation on the extreme traffic loading of bridges

Accurate traffic loading models based on measured data are essential for the accurate assessment of existing bridges. There are well-established methods for the Monte Carlo simulation of single lanes of traffic, and this can easily be extended to model the loading on bridges with two independent streams of traffic in opposing directions. However, a typical highway bridge will have multiple lanes in the same direction, and various types of correlation are evident in measured traffic. This paper analyses traffic patterns using multi-lane WIM data collected at two European sites. It describes an approach to the Monte Carlo simulation of this traffic which applies variable bandwidth kernel density estimators to empirical traffic patterns of vehicle weights, gaps and speeds. This method provides a good match with measured data for multi-truck bridge loading events, and it is shown that correlation has a small but significant effect on lifetime maximum load effects

Sludge Digestion By Anaerobic Fluidized Beds. II: Kinetic Model

A model has been developed to describe the gas production and soluble-COD variations from the digestion of waste-activated sludge in the anaerobic fluidized-bed reactor. It indicates that a substantial rate increase can be attained by prehydrolysis of the biological sludge, external to the reactor. The model indicates that the rate-limiting step is in the sludge hydrolysis. The model is developed from an assumption of first-order kinetics in a set of series and parallel, irreversible reactions. That is, the formation of soluble substrate is first order with respect to the particulate biomass present, and that the production of methane is first order with respect to the soluble substrate present. The amount of particulate biomass can be approximated by the sludge-suspended solids and that the amount of soluble substrate can be approximated by the soluble COD present in the reactor. The model correlates well with the laboratory data observed in the study. © ASCE

Effect of vibration duration on human discomfort

The duration effects of random vertical vibration on passenger discomfort were studied in a simulated section of an aircraft cabin configured to seat six persons in tourist-class style. Variables of the study included time of exposure (0.25 min to 60 min) and the rms amplitude of vibration (0.025g to 0.100g). The vibrations had a white noise spectrum with a bandwidth of 10 Hz centered at 5 Hz. Data indicate that the discomfort threshold occurred at an rms vertical acceleration level of 0.027g for all durations of vibration. However, for acceleration levels that exceeded the discomfort threshold, a systematic decrease in discomfort occurred as a function of increasing duration of vibration. For the range of accelerations used, the magnitude of the discomfort decrement was shown to be independent of acceleration level. The results suggest that discomfort from vertical vibration applied in the frequency range at which humans are most sensitive decreases with longer exposure, which is the opposite of the recommendation of the International Standard ISO 2631-1974 (E) Guide for the Evaluation of Human Exposure to Whole-Body Vibration

An experimental study for determining human discomfort response to roll vibration

An experimental study using a passenger ride quality apparatus (PRQA) was conducted to determine the subjective reactions of passengers to roll vibrations. The data obtained illustrate the effect upon human comfort of several roll-vibration parameters: namely, roll acceleration level, roll frequency, and seat location (i.e., distance from axis of rotation). Results of an analysis of variance indicated that seat location had no effect on discomfort ratings of roll vibrations. The effect of roll acceleration level was significant, and discomfort ratings increased markedly with increasing roll acceleration level at all roll frequencies investigated. Of particular interest, is the fact that the relationship between discomfort ratings and roll acceleration level was linear in nature. The effect of roll frequency also was significant as was the interaction between roll acceleration level and roll frequency

Non-immune fetal hydrops: etiology and outcome according to gestational age at diagnosis.

OBJECTIVE: Fetal hydrops is associated with increased perinatal morbidity and mortality. The etiology and outcome of fetal hydrops may differ according to the gestational age at diagnosis. The aim of this study was to evaluate the cause, evolution and outcome of non-immune fetal hydrops (NIFH), according to the gestational age at diagnosis. METHODS: This was a retrospective cohort study of all singleton pregnancies complicated by NIFH, at the Fetal Medicine Unit at St George's University Hospital, London, UK, between 2000 and 2018. All fetuses had detailed anomaly and cardiac ultrasound scans, karyotyping and infection screening. Prenatal diagnostic and therapeutic intervention, gestational age at diagnosis and delivery, as well as pregnancy outcome, were recorded. Regression analysis was used to test for potential association between possible risk factors and perinatal mortality. RESULTS: We included 273 fetuses with NIFH. The etiology of the condition varied significantly in the three trimesters. Excluding 30 women who declined invasive testing, the cause of NIFH was defined as unknown in 62 of the remaining 243 cases (25.5%). Chromosomal aneuploidy was the most common cause of NIFH in the first trimester. It continued to be a significant etiologic factor in the second trimester, along with congenital infection. In the third trimester, the most common etiology was cardiovascular abnormality. Among the 152 (55.7%) women continuing the pregnancy, 48 (31.6%) underwent fetal intervention, including the insertion of pleuroamniotic shunts, fetal blood transfusion and thoracentesis. Fetal intervention was associated significantly with lower perinatal mortality (odds ratio (OR), 0.30 (95% CI, 0.14-0.61); P  0.05). CONCLUSIONS: An earlier gestational age at diagnosis of NIFH was associated with an increased risk of aneuploidy and worse pregnancy outcome, including a higher risk of perinatal loss. Fetal therapy was associated significantly with lower perinatal mortality. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology

Noise and vibration ride comfort criteria

Two of the most important factors, namely, vibration and noise, were studied to (1) determine whether composite or separate noise and vibration criteria are needed for the prediction of ride quality, (2) determine a noise correction for the previously-defined vibration criteria of the ride quality model, (3) assess whether these noise corrections depend on the nature of the vibration stimuli, i.e., deterministic as opposed to random, and (4) specify noise-vibration criteria for this combined environment. The stimuli for the study consisted of octave bands of noise centered at 500 or 2,000 Hz and vertical vibrations composed of either 5 Hz sinusoidal vibration or random vibrations centered at 5 Hz and with a 5 Hz bandwidth. The noise stimuli were presented at levels ranging from ambient to 95 dB(A) and the vibrations at levels ranging from 0.02 to 0.13g rms