Selection of the optimal completion of horizontal wells with multi-stage hydraulic fracturing of the low-permeable formation, field C

At the moment, many fields of Western Siberia are in the later stages of development. In this regard, the multilayer fields are actually involved in the development of hard to recover reserves by conducting well interventions. However, most of these assets may not to be economical profitable without application of horizontal drilling and multi-stage hydraulic fracturing treatment. Moreover, location of frac ports in relative to each other, number of stages, volume of proppant per one stage are the main issues due to the fact that the interference effect could lead to the loss of oil production. The optimal arrangement of horizontal wells with multi-stage hydraulic fracture was defined in this paper. Several analytical approaches have been used to predict the started oil flow rate and chose the most appropriate for field C reservoir J1. However, none of the analytical equations could not take into account the interference effect and determine the optimum number of fractures. Therefore, the simulation modelling was used. Finally, the universal equation is derived for this field C, the reservoir J1. This tool could be used to predict the flow rate of the horizontal well with hydraulic fracturing treatment on the qualitative level without simulation model

Modulation of Circumstellar Extinction in a Young Binary System with a Low-Mass Companion in a Noncoplanar Orbit

The cyclic activity model of a young star with the low-mass secondary component (q = M2/M1 <= 0.1) accreting a matter from circumbinary disk is considered. It is assumed that the orbit is circular and the disk and orbital planes are non-coplanar. Sets of hydrodynamics models of such a system have been calculated by the SPH method and then the variations of the circumstellar extinction and phase light curves were determined. The calculations showed that depending on the model parameters and orientation of the system in regards to an observer the different in shape and amplitude light curves can be observed. An important property of the considered models is also the dependence of the mass accretion rate onto the components on the phase of the orbital period. The results of the calculation can be used for analysis of the cyclic activity of UX Ori stars and young stars with the long-lasting eclipses.Comment: 14 pages, 7 figure

Assessment of pharmacological activity and bioavailability of the new derivative 1,3,4-thiadiazole

Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were evaluate

Розробка порошкової харчової добавки на основі плодів обліпихи

In the process of food production, it is important not only to obtain a high quality product, but also to minimize industrial waste and reduce energy costs for the process. Recently, customers have been paying particular attention to the biological value of products, and the popularity of organic and natural products is growing. The search for new types of unconventional raw materials and the choice of a rational method of their processing is an important task for scientists and manufacturers. The aim of the study is to develop a technology for the production of a powdered food additive by using wild-growing raw materials of regional importance by osmotic dehydration. The use of osmotic dehydration preserves their biological value and organoleptic properties. The technology of osmotic dehydration processing of berries developed in this work allows the use of gentle drying modes, which contributes to the maximum preservation of their biological value. The presence of biologically active substances in sea buckthorn improves the chemical composition of food products. Standard organoleptic and microbiological methods of research were used. The article presents a technological scheme for the production of a powdered food additive based on sea buckthorn fruit. The physicochemical and organoleptic parameters of the finished product, the content of vitamins C and E were investigated. Given that wild berries were used for the study, the powders were tested for the presence of microorganisms (bacteria of the E. coli group (coliforms), the number of mesophilic aerobic and optional anaerobic microorganisms, yeast and molds) and toxic elements. All indicators are within the permissible limits. Thus, sea buckthorn fruit is a safe raw material. The microbiological parameters during long-term storage for 12 months were determined.У процесі виробництва харчового продукту важливим є не тільки отримання продукту високої якості, а й мінімізація промислових відходів, зниження енерговитрат на процес. Останнім часом покупці з особливою уважністю ставляться ще й до біологічної цінності, зростає популярність органічних і натуральних продуктів. Пошук нових видів нетрадиційної сировини та вибір раціонального способу її переробки – важливе завдання для науковців і виробничників. Метою дослідження є розроблення технології одержання порошкової харчової добавки за рахунок використання дикорослої сировини регіонального значення методом осмотичної дегідратації. При використанні осмотичної дегідратації зберігається їхня біологічна цінність та органолептичні властивості. Розроблена в роботі технологія обробки ягід осмотичною дегідратацією дає змогу використовувати щадні режими сушіння, що сприяє максимальному збереженню їхньої біологічної цінності. Наявність біологічно активних речовин в обліписі підвищує хімічний склад харчових продуктів. Використано стандартні органолептичні та мікробіологічні методи дослідження. У статті подана технологічна схема виробництва порошкової харчової добавки на основі плодів обліпихи. Досліджені фізико-хімічні та органолептичні показники готового продукту, вміст вітамів С та Е. З огляду на те, що для дослідження використовувалися дикорослі ягоди, проведено дослідження порошків на наявність мікроорганізмів (бактерії групи кишкових паличок (коліформи), кількість мезофільних аеробних і факультативно анаеробних мікроорганізмів, дріжджі та плісневі гриби) та токсичних елементів. Всі показники –&nbsp; в межах допустимих норм. Таким чином, плоди обліпихи є безпечною сировиною. Визначено мікробіологічні показники при тривалому зберіганні протягом 12 місяців

Prediabetes. A new paradigm for early prevention of cardiovascular disease

This literature review focuses on the association of prediabetes with cardiovascular disease (CVD). Recently, much attention has been paid to the study of prediabetes due to its extremely high prevalence and strong association with a high risk of developing serious complications that worsen the quality of kife of patients. Prediabetes is not only a metabolic condition with a high risk of developing type 2 diabetes mellitus (T2DM), but also CVD and death from all causes. This association is true for both patients who do not yet have CVD and those with a history of CVD. Also during the COVID-19 pandemic, attention is drawn to the fact that people with prediabetes have a higher risk of a severe course of infection, complications and a worse prognosis of the disease. This is associated with hyperglycemia, the  presence of  chronic systemic inflammation of  a  low degree of  activity, impaired immune response mechanisms and a procoagulant state in patients with prediabetes, although these disorders are less developed than in patients with T2DM. Therefore, early screening of early disorders of normal metabolism. Since active early intervention at the stage of prediabetes helps to prevent the development of type 2 diabetes and CVD

Statistical methods for analyzing financial statements of Russian organizations in the context of IFRS implementation

In the context of the transition to international financial reporting standards (hereinafter - IFRS), issues of bringing Russian financial statements closer to an international format are of relevance. In order to develop Russian reporting adapted to the new requirements of the format, the authors have conducted polls of the accounting services of large, medium and small business organizations about the desirability of including the indicators from the minimum list of international reporting articles in their reports. Based on the methods used by the Institute of Statistics in the study of Russian financial statements methods of selective observation, questioning, methods of processing the data obtained, namely, calculating the proportion of reporting indicators using the A. Salai and V. Ryabtsev index, the authors justify the inclusion in the Russian financial reporting a series of indicators proposed by IFRS. The results of the study can be used in the transformation of statements, as well as in the construction of consolidated financial statements generated in Russia in accordance with the requirements of IFRS.peer-reviewe