Baikal-GVD

We present the status of the Gigaton Volume Detector in Lake Baikal (Baikal-GVD) designed for the detection of high energy neutrinos of astrophysical origin. The telescope consists of functionally independent clusters, sub-arrays of optical modules (OMs), which are connected to shore by individual electro-optical cables. During 2015 the GVD demonstration cluster, comprising 192 OMs, has been successfully operated in Lake Baikal. In 2016 this array was upgraded to baseline configuration of GVD cluster with 288 OMs arranged on eight vertical strings. Thus the instrumented water volume has been increased up to about 5.9 Mtons. The array was commissioned in early April 2016 and takes data since then. We describe the configuration and design of the 2016 array. Preliminary results obtained with data recorded in 2015 are also discussed

Accumulation of storage proteins in plant seeds is mediated by amyloid formation

Copyright: © 2020 Antonets et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Amyloids are protein aggregates with a highly ordered spatial structure giving them unique physicochemical properties. Different amyloids not only participate in the development of numerous incurable diseases but control vital functions in archaea, bacteria and eukarya. Plants are a poorly studied systematic group in the field of amyloid biology. Amyloid properties have not yet been demonstrated for plant proteins under native conditions in vivo. Here we show that seeds of garden pea Pisum sativum L. contain amyloid-like aggregates of storage proteins, the most abundant one, 7S globulin Vicilin, forms bona fide amyloids in vivo and in vitro. Full-length Vicilin contains 2 evolutionary conserved β-barrel domains, Cupin-1.1 and Cupin-1.2, that self-assemble in vitro into amyloid fibrils with similar physicochemical properties. However, Cupin-1.2 fibrils unlike Cupin-1.1 can seed Vicilin fibrillation. In vivo, Vicilin forms amyloids in the cotyledon cells that bind amyloid-specific dyes and possess resistance to detergents and proteases. The Vicilin amyloid accumulation increases during seed maturation and wanes at germination. Amyloids of Vicilin resist digestion by gastrointestinal enzymes, persist in canned peas, and exhibit toxicity for yeast and mammalian cells. Our finding for the first time reveals involvement of amyloid formation in the accumulation of storage proteins in plant seeds

Baikal-GVD

We present the status of the Gigaton Volume Detector in Lake Baikal (Baikal-GVD) designed for the detection of high energy neutrinos of astrophysical origin. The telescope consists of functionally independent clusters, sub-arrays of optical modules (OMs), which are connected to shore by individual electro-optical cables. During 2015 the GVD demonstration cluster, comprising 192 OMs, has been successfully operated in Lake Baikal. In 2016 this array was upgraded to baseline configuration of GVD cluster with 288 OMs arranged on eight vertical strings. Thus the instrumented water volume has been increased up to about 5.9 Mtons. The array was commissioned in early April 2016 and takes data since then. We describe the configuration and design of the 2016 array. Preliminary results obtained with data recorded in 2015 are also discussed