Tourism development in Ukraine

All prerequisites for development of the tourism industry in Ukraine exist. These include a convenient geographical location, favourable climate, varied terrain, a unique combination of natural and recreational resources, cultural heritage, specialised health-resorts. Combined with good value for money, all these factors confer a competitive advantage for Ukraine’s tourist offer

Smoke detector

A smoke detector is made to alert people when the fire begins. It has already saved millions of lives and it is still rather promising for the future

Tourism development in Ukraine

All prerequisites for development of the tourism industry in Ukraine exist. These include a convenient geographical location, favourable climate, varied terrain, a unique combination of natural and recreational resources, cultural heritage, specialised health-resorts. Combined with good value for money, all these factors confer a competitive advantage for Ukraine’s tourist offer

Smoke detector

A smoke detector is made to alert people when the fire begins. It has already saved millions of lives and it is still rather promising for the future

Computer screening of peptidomimetics and small-molecule ligands of B-cell membrane proteins for therapy of Burkitt lymphoma

The capabilities of molecular modelling and docking allow for the discovery of new potential drug agents to improve the treatment of diseases, which is a current concern. The objective of this study was to conduct in silico screening for antibody mimetics to B-cell membrane proteins for the treatment of Burkitt lymphoma through virtual screening. In this work, a standard protocol for structure-based virtual screening was employed, with the distinction that pharmacophores for screening were built not based on small-molecule ligands but on selected amino acid residues of antibodies. Based on literature data and the presence of a mechanism of direct cytotoxic action, as well as the availability of 3D structures of complexes, three monoclonal antibodies were selected: obinutuzumab, epratuzumab, and atezolizumab. The identification of biological targets was carried out by searching for 3D structures of selected complexes with target proteins in the Protein Data Bank. For virtual screening, the web service Pharmit was chosen. Using the Molecular Operating Environment program, pharmacophore models were constructed for three complexes: CD20 and obinutuzumab, CD22 and epratuzumab, and PD-L1 and atezolizumab. Docking with the CD20, CD22, and PD-L1 proteins was conducted at the binding sites recognised by the original antibody. Through in silico virtual screening using the Molecular Operating Environment software, a search for antibody mimetics to B-cell membrane proteins for Burkitt lymphoma treatment was conducted, resulting in the selection of 5 potential anti-lymphoma agents: CHEMBL505179 for the CD20 receptor, an antagonist of the melanocortin receptor for CD20 (PubChem-44406884), an inhibitor of blood clotting Factor Xa for CD22 (PubChem-136510605), and a blocker of epithelial Na+ channels for CD22 (PubChem-126761430), and an agonist of the melanocortin receptor for PD-L1 (PubChem-25078192). The obtained results can be applied in the pharmaceutical industry and oncological practice to enhance therapeutic outcomes in the treatment of patients with Burkitt lymphom

ВОЗМОЖНОСТИ СНИЖЕНИЯ ЭКОЛОГИЧЕСКИХ ПЛАТЕЖЕЙ

The author proposes methods to substantiate reduction of ecological payments of business entities for air pollution. He argues for the following preconditions: regular instrumental control of hazardous emissions and their ground concentration at the border of sanitary protection zone, existence and functioning of ecological management system.Предложена методика обоснования уменьшения размеров экологических платежей за выбросы загрязняющих веществ в атмосферу. Организация систематического инструментального контроля вредных выбросов и их приземных концентраций на границе санитарно-защитной зоны при условии наличия и функционирования системы экологического менеджмента

ИДЕНТИФИКАЦИЯ ЭКОАСПЕКТОВ В ИЕРАРХИЧЕСКИХ СТРУКТУРАХ

Hierarchically sophisticated structures, like transportation complex, request specific means of environmental planning and management. Therefore, both criteria and tools of ecological assessment of real state of the industry are equally important. The author proposes techniques to identify ecological aspects, notably the significant ones for environmental protection.Иерархически сложная организационная структура типа транспортного комплекса нуждается в специфических средствах планирования и управления в природоохранной сфере. При этом одинаково важны и критерии, и механизмы оценки реального состояния производства с точки зрения экологических рисков. Предложена методика идентификации экологических аспектов, в том числе значимых, особо существенных для защиты окружающей среды

Magnetic force microscopy of atherosclerotic plaque.

In this work by methods of scanning probe microscopy, namely by atomic force microscopy and magnetic force microscopy the fragments of atherosclerotic plaque section of different nature were investigated. The fragments of atherosclerotic vessels with elements of immature plaque were taken during the coiled artery bypass surgery by alloprosthesis. As the result of investigation we found magnetically ordered phase of endogenous origin in the fragment of solid plaque of mixed structure. This phase is presents biogenic magnetic nanoparticles and their clusters with average size characteristic of 200-400 nm