Effect of angiotensin converting enzyme inhibitors on periprocedural myocardial infarction in patients with metabolic syndrome

Background: Metabolic syndrome (MetS) has been reported as a risk factor for cardiovascular events. The aim of the present study is to investigate the association between chronic angiotensin-converting enzyme inhibitors (ACE-I) therapy and the rate of periprocedural myocardial infarction (PMI) after elective coronary stenting among patients with MetS. Methods: The inclusion criteria were MetS and plan for elective percutaneous coronary intervention. To assess the effect of ACE-I treatment on the incidence of PMI, measurements of cardiac biomarkers (CK-MB mass and troponin I) were performed at baseline and 24 h after the procedure. Results: A total of 459 patients fulfilling the inclusion criteria were recruited to chronic ACE-I treatment and ACE-I naive groups in a 2/1 ratio. Baseline troponin I and CK-MB levels were similar in both treatment groups, whereas they were significantly lower in ACE-I group 24 h after the procedure. Univariate analysis identified body mass index (BMI), LDL cholesterol, nitrate and ACE-I use as significant factors for the development of PMI. Multivariate regression model revealed that body mass index increased and use of nitrate and ACE-I decreased the probability of PMI independent from confounding factors (OR 1.14, 95% CI 1.05–1.23, p = 0.002 for BMI; OR 0.26, 95% CI 0.14–0.48, p = 0.01 for nitrate use, OR 0.51, 95% CI 0.27–0.93, p = 0.03 for ACE-I use). Conclusions: This prospective observational cohort trial demonstrated that chronic ACE-I therapy was an independent predictor for reduced PMI among patients with MetS who underwent elective coronary intervention

From Betriebswirtschaftslehre to human relations: Turkish management literature before and after the Second World War

This article examines Turkish management literature from its beginnings in the mid-1930s up to the mid-1960s. The study traces and explores the impact of economic and political as well as institutional developments on the extent and changes in the reception that different management approaches have enjoyed in this formative period. Investigation of the management literature produced over the course of the 30-year time span shows that the business economics perspective that dominated pioneering work gave way after early 1950s to a Fayolist management process approach coupled with a human relations orientation. Taylorism attracted limited attention throughout the entire period. The article attempts to show that these findings can be traced to the shift from links with Germany and the German literature in early years to a strong American influence after the Second World War

Modelling between epistemological beliefs and constructivist learning environment

The purpose of this study was to model the relationship between pre-service chemistry teachers' epistemological beliefs and their preference to use constructivist-learning environment in their future class. The sample was 125 pre-service chemistry teachers from five universities in Turkey. Two instruments were used in this study. One of the instruments was constructivist-learning environment scale developed by Taylor, Fraser and Fisher. The other instrument was Epistemological Questionnaire (EQ) developed by Schommer. In order to analyse data, Structural Equation Modelling was conducted by using LISREL 8.7. The results provided evidence for the good fit of the hypothesised model. Pre-service chemistry teachers' epistemological belief scores were found to be correlated to their constructivist-learning environment scale scores with the value of .35. This study revealed that pre-service chemistry teachers with sophisticated epistemological beliefs favoured constructivist-learning environment in their future class

Blackberry and raspberry are alternative resistance sources to fire blight

Erwinia amylovora causes fire blight mainly on pear, apple and quince trees. This bacterial pathogen also infects other Rosaceous plants, such as blackberry and raspberry. A race structure was established between an isolate of E. amylovora and berries using 40 wild blackberry and 7 wild raspberry genotypes. In pathogenicity tests, wild blackberry and raspberry genotypes had three phenotypic reactions: enhanced susceptibility, moderate susceptibility and resistance. We noted a higher bacterial growth of over 300 × 109 cfu mL-1 in plants with enhanced susceptibility, with resistant genotypes showing a bacterial growth of around 150 × 109 cfu mL-1. These results are also associated with symptoms observed at 29 days post-inoculation. This resistance is being evaluated to control fire blight.Erwinia amylovora est responsable de la brûlure bactérienne principalement chez la poire, la pomme et le coing. Cet agent pathogène bactérien infecte également d’autres plants de Rosaceous, comme les mûriers et les framboisiers. Une structure de race a été établie entre un isolat de E. amylovora et ces baies en utilisant 40 génotypes de mûrier sauvage et 7 de framboisier sauvage. Lors de tests de pathogénicité, les génotypes de mûrier et framboisier sauvages ont montré trois réactions génotypiques, soit une sensibilité accrue, une sensibilité intermédiaire et de la résistance. Nous avons noté une plus grande croissance bactérienne de plus de 300 × 109 cfu mL-1 chez les plants avec une sensibilité accrue, alors que les génotypes résistants montraient une croissance bactérienne d’environ 150 × 109 cfu mL-1. Ces résultats sont également liés aux symptômes observés 29 jours après l’inoculation. Cette résistance fait l’objet d’évaluation pour la lutte à la brûlure bactérienne

A study of three bacteria isolated from marine sediment and description of Micromonospora globispora sp. nov.

19 páginas, 2 figuras, 4 tablasDuring a study looking for the isolation of new actinobacteria strains with potential for antibiotic production from deep marine sediment, three strains were collected with a morphology similar to the one described for the Micromonospora genus. A polyphasic study was designed to determine the taxonomic affiliation of the strains S2901T, S2903, and S2904. All the strains showed chemotaxonomic properties in line with their classification in the genus Micromonospora, meso-diaminopimelic acid in the wall peptidoglycan, a tetrahydrogenated menaquinone with nine isoprene units as major respiratory quinone, iso-C15:0 and iso-C16:0 as major fatty acids and diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylinositol as major polar lipids. The 16S rRNA gene sequences of strain S2901T, S2903, and S2904 showed the highest similarity (99.2%) with the type strain of Micromonospora halophytica DSM 43171T, forming an independent branch in the phylogenetic gene tree. Their independent position was confirmed with gyrB gene and MLSA phylogenies. Whole genome sequences confirmed by digital DNA-DNA hybridization analysis that the isolates should be assigned to a new species within the genus Micromonospora for which the name Micromonospora globispora sp. nov. (S2901T, S2903 and S2904) is proposed.This project was supported by Ondokuz Mayis University (project PYO. FEN. 1901.12.014) and the School of Biology (Newcastle University).Peer reviewe

Poly-beta-hydroxybutyrate accumulation and releasing by hydrogen producing bacteria, Rhodobacter sphaeroides OU001. A transmission electron microscopic study

Photosynthetic bacterium Rhodobacter sphaeroides O.U.001 that is used for photobiohydrogen production can also accumulate poly-beta-hydroxybutyrate (PHB) as a by-product when cultivated anaerobically with minimal medium containing L-malic acid, sodium glutamate and some vitamins under illumination. Transmission electron microscopy studies revealed that PHB granules are made of two distinct components: a homogenous and electron lucent core is covered with a more electron dense coat. PHB granules were observed in the cytoplasm, outside of the cells, in the center of cotton like aggregates in the cells, or while they were being released from the cell. In this study, two kinds of releasing were revealed; with lysis and without lysis of cell wall. Release of intact polymer outside the cells could be economically feasible way to obtain PHB for industrial applications