State support of stability in Coal-Donbas regions

Purpose. To develop a new approach to feasibility assessment mechanism of supporting production facilities of loss-making mines in Donetsk and Dnipropetrovsk regions. Methods. To solve the objective set, a complex approach was used including as-sessment of enterprise investment attractiveness, determination of production potential, definition of the ability to switch to a break-even mode. The process for planning ways to save the industrial potential of coal-mining regions may be considered as the reflection of multidimensional space (initial and design values) into the one-dimensional (amount of investment money). Findings. It has been established that on the stage of building a model for managing mine unprofitability decrease processes, it is necessary to overview 8-10 factorial features, which may determine the formation of economic potential, taking into consideration peculiarities of remaining deposit bedding and their quality, as integral assessment of mine potential in terms of (state and non-state) investment perception. The objective set comes down to selection of the mini-mum number of factors, which would the most adequately reflect the mine internal potential expressed by economic value added – as a consequence of interaction of factors of coal mine economic activities in specific mining, geological and technological conditions. Originality. The academic novelty is that as a complex component of the state of the loss-making mine, it is reasonable to use an indicator of economic reliability, which synthesizes the capacity of links, economic level of technical and economic indicators and the amount of remaining deposits. The latter determine the residual life of the mine, physical content of the proposed indicators is not identical, and it is this fact, which allows for their joint use to obtain a more complete estimate than when using any single indicator. Practical implications. Practical significance includes actual assessment of the state of Donbass coal enterprises and determination of marginal break-even indicators, which allowed for the formation of recommendations for attracting financial resources

Анальгезивна та протизапальна дії похідних 5,7-діацил- 3-H(алкіл)-6-арил-5Н-[1,2,4]тріазоло[3,4-b][1,3,4]тіадіазину

The search for new analgesic and anti-inflammatory drugs, exceeding by efficacy and/or safety the existinganalogues is very important and relevant. The nitrogenous heterocycles are promising in this respect, in particular,the compounds containing an imidazole triazol and tіadiazin moiety. The aim of the current study was to investigatethe antiexudative and antinociceptive activity of new derivatives of 5,7-diacyl-3-H(alkyl)-6-aryl-5H[1,2,4]triazol[3,4-b][1,3,4]thiadiazine.The antinociceptive and antiexudative activity studies were carried out on the white nonlinear mice. Theexperimental evaluation of specific activity was carried out on the models “Hot plate”, acetic acid induced writhing(antinociceptive action) and carrageenan edema (antiexudative action). The substance was used in a single oral routadministration in a dose of 25 mg/kg. Ketorolac was used as a reference product in the dose of 25 mg/kg (models“Hot plate”, acetic acid induced writhing). Diclofenac was used as a reference product in the dose of 25 mg/kg onthe model carrageenan edema. The experimental study showed the antinociceptive and antiexudative effects of thederivatives. The antinociceptive activity of 5,7-diacyl-3-H(alkіl)-6-aryl-5H[1,2,4]triazol[3,4-b][1,3,4]tіadiazin derivatiesrelated to the modification structure in the para position of benzene ring. The antiexudative activity is associated withacetyl groups thiadiazine ring. The most promising compound IFT_247 showed a significant antinociceptive effect,which is comparable to an active comparator ketorolac: “Hot plate” +232.46 % and +112.71 %; acetic acid inducedwrithing -66.67 % and -61.02 %, respectively.Поиск новых анальгезирующих и противовоспалительных препаратов, превосходящих по эффектив-ности и/или безопасности существующие аналоги, важен и актуален. В этом отношении перспективныазотистые гетероциклы, в частности соединения, содержащие в себе триазоловый и тиадиазиновыйфрагменты.Была поставлена цель исследовать антиноцицептивную и антиэксудативную активность новыхпроизводных 5,7-диацил-3-H(алкил)-6-арил-5Н-[1,2,4]триазоло[3,4-b][1,3,4]тиадиазина.Исследование проведено на белых нелинейных мышах обоего пола. Оценено антиноцицептивную иантиэксудативную активность пяти производных 5,7-диацил-3-H(алкил)-6-арил-5Н-[1,2,4]триазоло[3,4-b][1,3,4]тиадиазина на моделях “горячей пластины, уксуснокислых “корчей” (антиноцицептивный эффект)и каррагенинового отека (антиэкссудативное действие) при однократном внутрижелудочном введении вдозе 25 мг/кг. В качестве препаратов сравнения использовали кеторолак в дозе 25 мг/кг (“горячая пласти-на”, уксуснокислые “корчи”) и диклофенак натрия в дозе 25 мг/кг (каррагениновый отек). Исследованныесоединения показали наличие достоверного антиноцицептивного и антиэкссудативного эффектов.Антиноцицептивная активность ряда связана с модификацией структуры 5,7-диацил-3-H(алкил)-6-арил-5Н-[1,2,4]триазоло[3,4-b][1,3,4]тиадиазина в параположении бензольного кольца. Антиэкссудативнаяактивность – с ацетиловыми группами тиадиазинового кольца. Наиболее перспективным являетсясоединение IFT_247, проявляющее значительный анальгезирующий эффект в эксперименте и не усту-пающее по активности препарату сравнения – кеторолаку: “горячая пластина” – +232,46 и +112,71 %;уксуснокислые “корчи” – -66,67 и -61,02 % соответственно.Пошук нових анальгезивних і протизапальних препаратів, що переважають за ефективністю та/абобезпекою існуючі аналоги, є важливим і актуальним. У цьому відношенні перспективні азотисті гетеро-цикли, зокрема сполуки, що містять у собі тріазоловий і тіадіазиновий фрагменти.Було поставлено мету дослідити антиноцицептивну та антиексудативну активність нових похідних5,7-діацил-3-H(алкіл)-6-арил-5Н-[1,2,4]тріазоло[3,4-b][1,3,4]тіадіазину.Дослідження проведено на білих нелінійних мишах обох статей. Оцінено антиноцицептивну йантиексудативну активність п’яти похідних 5,7-діацил-3-H(алкіл)-6-арил-5Н-[1,2,4]тріазоло[3,4-b][1,3,4]тіадіазину на моделях “гарячої пластини”, оцтовокислих “корчів” (антиноцицептивний ефект) ікарагенінового набряку (антиексудативна дія) при одноразовому внутрішньошлунковому введенні в дозі25 мг/кг. Як препарати порівняння використовували кеторолак у дозі 25 мг/кг (“гаряча пластина”, оцтовокислі“корчі”) і диклофенак натрію в дозі 25 мг/кг (карагеніновий набряк). Досліджені сполуки показали наявністьдостовірного антиноцицептивного й антиексудативного ефектів. Антиноцицептивна активністьряду пов’язана з модифікацією структури 5,7-діацил-3-H(алкіл)-6-арил-5Н-[1,2,4]тріазоло[3,4-b][1,3,4]тіадіазину в параположенні бензольного кільця. Антиексудативна активність – з ацетиловими групамитіадіазинового кільця. Найбільш перспективною є сполука IFT_247, що проявляє значний анальгезивнийефект в експерименті й не поступається за активністю препарату порівняння – кеторолаку: “гарячапластина” – +232,46 і +112,71 %; оцтовокислі “корчі” – -66,67 і -61,02 % відповідно

Non-parametric models of stochastic systems with delay

The paper considers an identiЇcation problem for stochastic static systems with delay. The identiЇcation problem is investigated in a broad sense, specially under conditions of non-parametric uncertainty, i. e. in the case when parametric structure of the model is known to within parameters vector. The new classes of non-parametric estimations of regression line of observations is proposed. The paper gives the corresponding theorems of convergence for non-parametric esti- mation and models

Non-parametric models of stochastic systems with delay

The paper considers an identiЇcation problem for stochastic static systems with delay. The identiЇcation problem is investigated in a broad sense, specially under conditions of non-parametric uncertainty, i. e. in the case when parametric structure of the model is known to within parameters vector. The new classes of non-parametric estimations of regression line of observations is proposed. The paper gives the corresponding theorems of convergence for non-parametric esti- mation and models

Ribonuclease activity of buckwheat plant (Fagopyrum esculentum) cultivars with different sensitivities to buckwheat burn virus

Ribonucleases (RNases) are present in base-level amounts in intact plants, but this level is able to increase greatly under stress conditions. The possible cause for such an increase is protection against plant RNA-virus attack. Buckwheat burn virus (BBV) is a highly virulent pathogen that belongs to Rhabdoviridae family. In our study, we have analyzed the correlation between RNase activity and resistance of different buckwheat cultivars to BBV infection. Two cultivars, Kara-Dag and Roksolana, with different sensitivities to BBV have been used. Kara-Dag is a cultivar with medium sensitivity to virus and Roksolana is a tolerant cultivar. It has been shown that the base level of RNase activity in Roksolana cultivar was in most cases higher than the corresponding parameter in Kara-Dag cultivar. Both infected and uninfected plants of Roksolana cultivar demonstrated high RNase activity during two weeks. Whereas infected plants of Kara-Dag cultivar demonstrated unstable levels of RNase activity. Significant decline in RNase activity was detected on the 7th day post infection with subsequent gradual increase in RNase activity. Decline of the RNase activity during the first week could promote the virus replication and therefore more successful infection of upper leaves of plants. Unstable levels of RNase activity in infected buckwheat plants may be explained by insufficiency of virus-resistant mechanisms that determines the medium sensitivity of the cultivar to BBV. Thus, plants of buckwheat cultivar having less sensitivity to virus, displayed in general higher RNase activity

Redistribution of Tb and Eu ions in ZnO films grown on different substrates under thermal annealing and its impact on Tb-Eu energy transfer

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