Do trade preferential agreements enhance the exports of developing countries? Evidence from the EU GSP

The EU grants preferential access to its imports from developing countries under several trade agreements. The widest arrangement, in terms of country and product coverage, is the Generalised System of Preferences (GSP) through which, since 1971, virtually all developing countries have received preferential treatment when exporting to world markets. This paper evaluates the impact of GSP in enhancing developing countries’ exports to EU markets. It is based on the estimation of a gravity model for a sample of 769 products exported from 169 countries to EU over the period 2001-2004. While, from an econometric point of view, the estimation methods take into account unobservable country heterogeneity as well as the potential selection bias which zero-trade values pose, the empirical setting considers an explicit measure of trade preferences, the margin of preferences. The analysis offers new empirical evidence that the impact of GSP on developing countries’ agricultural exports to the EU is positive.Trade Preferences, Developing Countries, Agricultural Trade

Neutrino masses in quartification schemes

The idea of quark-lepton universality at high energies has recently been explored in unified theories based upon the quartification gauge group SU(3)^4. These schemes encompass a quark-lepton exchange symmetry that results upon the introduction of leptonic colour. It has been demonstrated that in models in which the quartification gauge symmetry is broken down to the standard model gauge group, gauge coupling constant unification can be achieved, and there is no unique scenario. The same is also true when the leptonic colour gauge group is only partially broken, leaving a remnant SU(2)_\ell symmetry at the standard model level. Here we perform an analysis of the neutrino mass spectrum of such models. We show that these models do not naturally generate small Majorana neutrino masses, thus correcting an error in our earlier quartification paper, but with the addition of one singlet neutral fermion per family there is a realisation of see-saw suppressed masses for the neutrinos. We also show that these schemes are consistent with proton decay.Comment: 12 pages, minor changes. To appear in Phys. Rev.

The convergence of radiation and immunogenic cell death signaling pathways.

Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms, including apoptosis, necrosis, mitotic catastrophe (MC), autophagy, and senescence, which may occur concurrently. When considering tumor cell death in the context of an organism, an emerging body of evidence suggests there is a reciprocal relationship in which radiation stimulates the immune system, which in turn contributes to tumor cell kill. As a result, traditional measurements of radiation-induced tumor cell death, in vitro, fail to represent the extent of clinically observed responses, including reductions in loco-regional failure rates and improvements in metastases free and overall survival. Hence, understanding the immunological responses to the type of radiation-induced cell death is critical. In this review, the mechanisms of radiation-induced tumor cell death are described, with particular focus on immunogenic cell death (ICD). Strategies combining radiotherapy with specific chemotherapies or immunotherapies capable of inducing a repertoire of cancer specific immunogens might potentiate tumor control not only by enhancing cell kill but also through the induction of a successful anti-tumor vaccination that improves patient survival

Interaction of the Opiate and Neuroendocrine Systems

Opiates are known to produce various physiological effects. Our understanding of these effects has been greatly increased by the discovery of the opiate receptor and the endogenous opioid peptides. Recent investigation has demonstrated that three distinct receptor subtypes exist; their function is currently being actively investigated

Pesticides Residues and Trade: the Apple of Discord?

The impact of food safety standards on international trade has already been addressed. Generally, economists try to assess trade losses borne by exporters when importing countries impose stricter regulations. In this paper we assess the impact of the Maximum Residue Levels (MRL) of pesticides on the trade of apples and pears. Rather than focusing on a particular pesticide we take into account the entire list of substances set out by the various regulations with the aim is to understand how the similarity (or dissimilarity) of these can affect trade. Most studies assess the impact of sanitary standard regulations introducing directly in the analysis the MLR put in force in the importing country. We assume that what can be crucial is the difference in the tolerance levels of both the importing and exporting country. Having built a similarity index we then introduce it into a gravity equation to assess the impact of differences in MRL of pesticides on the trade of apples and pears of seven exporting and seven importing countries. Results suggest that harmonizing regulations impacts trade differently depending on the exporter.food safety, standards, pesticides, MRL, apple, pear, market access, Crop Production/Industries, International Relations/Trade, Q17, F13,

Using a Gridded Global Dataset to Characterize Regional Hydroclimate in Central Chile

Central Chile is facing dramatic projections of climate change, with a consensus for declining precipitation, negatively affecting hydropower generation and irrigated agriculture. Rising from sea level to 6000 m within a distance of 200 km, precipitation characterization is difficult because of a lack of long-term observations, especially at higher elevations. For understanding current mean and extreme conditions and recent hydroclimatological change, as well as to provide a baseline for downscaling climate model projections, a temporally and spatially complete dataset of daily meteorology is essential. The authors use a gridded global daily meteorological dataset at 0.25° resolution for the period 1948–2008, adjusted by monthly precipitation observations interpolated to the same grid using a cokriging method with elevation as a covariate. For validation, daily statistics of the adjusted gridded precipitation are compared to station observations. For further validation, a hydrology model is driven with the gridded 0.25° meteorology and streamflow statistics are compared with observed flow. The high elevation precipitation is validated by comparing the simulated snow extent to Moderate Resolution Imaging Spectroradiometer (MODIS) images. Results show that the daily meteorology with the adjusted precipitation can accurately capture the statistical properties of extreme events as well as the sequence of wet and dry events, with hydrological model results displaying reasonable agreement with observed streamflow and snow extent. This demonstrates the successful use of a global gridded data product in a relatively data-sparse region to capture hydroclimatological characteristics and extremes

Refinement and preliminary evaluation of two tablet-based tests of real-world visual function

PURPOSE: To describe, refine, evaluate, and provide normative control data for two freely available tablet-based tests of real-world visual function, using a cohort of young, normally-sighted adults. METHODS: Fifty young (18-40 years), normally-sighted adults completed tablet-based assessments of (1) face discrimination and (2) visual search. Each test was performed twice, to assess test-retest repeatability. Post-hoc analyses were performed to determine the number of trials required to obtain stable estimates of performance. Distributions were fitted to the normative data to determine the 99% population-boundary for normally sighted observers. Participants were also asked to rate their comprehension of each test. RESULTS: Both tests provided stable estimates in around 20 trials (~1-4 min), with only a further reduction of 14%-17% in the 95% Coefficient of Repeatability (CoR95 ) when an additional 40 trials were included. When using only ~20 trials: median durations for the first run of each test were 191 s (Faces) and 51 s (Search); test-retest CoR95 were 0.27 d (Faces) and 0.84 s (Search); and normative 99% population-limits were 3.50 d (Faces) and 3.1 s (Search). No participants exhibited any difficulties completing either test (100% completion rate), and ratings of task-understanding were high (Faces: 9.6 out of 10; Search: 9.7 out of 10). CONCLUSIONS: This preliminary assessment indicated that both tablet-based tests are able to provide simple, quick, and easy-to-administer measures of real-world visual function in normally-sighted young adults. Further work is required to assess their accuracy and utility in older people and individuals with visual impairment. Potential applications are discussed, including their use in clinic waiting rooms, and as an objective complement to Patient Reported Outcome Measures (PROMs)

Quartification On An Orbifold

We investigate quartification models in five dimensions, with the fifth dimension forming an $S^1/Z_2\times Z_2'$ orbifold. The orbifold construction is combined with a boundary Higgs sector to break the quartified gauge group directly to a group $H\subset SU(3)^4$ which is operative at the electroweak scale. We consider $H=G_{SM}\otimes SU(2)_\ell$ and $H=G_{SM}$, where $G_{SM}$ is the standard model gauge group, and find that unification occurs only when the remnant leptonic colour symmetry $SU(2)_\ell$ remains unbroken. Furthermore, the demands of a realistic low energy fermion spectrum specify a unique symmetry breaking route for the unifying case of $H=G_{SM}\otimes SU(2)_\ell$. We contrast this with four dimensional quartification models where unification may be achieved via a number of different symmetry breaking routes both with and without the remnant $SU(2)_\ell$ symmetry. The boundary Higgs sector of our model may be decoupled to achieve a Higgsless limit and we show that the electroweak Higgs doublet may be identified as the fifth component of a higher dimensional gauge field.Comment: 14 pages, misprint corrected, matches PRD versio

High power coupled CO2 waveguide laser array

A hollow-bore ridge waveguide technique for phase locking arrays of coupled CO2 rf excited waveguide lasers was demonstrated. Stable phase-locked operation of two- and three-channel arrays has been demonstrated at the 50 W output level. Preliminary experiments with a five-element array generated an output power of 95 W but phase-locked operation was not conclusively demonstrated