Observations sur le mode d’action des vaccins tués Vaccin solubilisé immunigène contre le rouget du Porc

Delpy Louis-Pierre, Hars E. Observations sur le mode d’action des vaccins tués. Vaccin solubilisé immunigène contre le Rouget du Porc. In: Bulletin de l'Académie Vétérinaire de France tome 106 n°10, 1953. pp. 539-546

Recherches sur la vaccination contre la maladie de Newcastle et la Variole par virus vivants associés

Delpy L.-P., Hars E. Recherches sur la vaccination contre la maladie de New-Castle et la variole par virus vivants associés. In: Bulletin de l'Académie Vétérinaire de France tome 106 n°3, 1953. pp. 175-187

Inoculation de E. Rhusiopathiæ par voie intradermique . Application au titrage des vaccins et serums contre le Rouget du Porc

Io L’injection dans le derme cutané du porc de suspensions titrées d E. rhasiopathiœ provoque l’évolution au point d’ino culation d’une lésion spécifique dont l’importance est fonction : a) De la dose inoculée (virulence de la souche et nombre de bacilles), b) De la réceptivité du sujet; 2° L’un de ces facteurs étant rendu constant, la lecture des réactions permet de mesurer l’autre ; 3° La méthode a permis trois applications pratiques : évalua tion de souches inconnues, mesure de l’efficacité des vaccins, titrage de sérum anti-rouget. Les résultats obtenus concordent avec les résultats fournis par les méthodes basées sur l’infection générale des sujets ; 4° La méthode proposée est précise, peu coûteuse, et d’exé cution facile

Immunisation des chevaux contre la fièvre charbonneuse et le tétanos, par vaccins associés

Delpy Louis-Pierre, Chamsy H. Mir. Immunisation des Chevaux contre la fièvre charbonneuse et le tétanos, par vaccins associés. In: Bulletin de l'Académie Vétérinaire de France tome 104 n°1, 1951. pp. 62-65

Creation and dynamics of spin fluctuations in a noisy magnetic field

We theoretically and numerically investigate the spin fluctuations induced in a thermal atomic ensemble by an external fluctuating uniaxial magnetic field, in the context of a standard spin noise spectroscopy (SNS) experiment. We show that additional spin noise is excited, which dramatically depends on the magnetic noise variance and bandwidth, as well as on the power of the probe light and its polarization direction. We develop an analytical perturbative model proving that this spin noise first emerges from the residual optical pumping in the medium, which is then converted into spin fluctuations by the magnetic noise and eventually detected using SNS. The system studied is a spin-1 system, which thus shows both Faraday rotation and ellipticity noises induced by the random magnetic fluctuations. The analytical model gives results in perfect agreement with the numerical simulations, with potential applications in future experimental characterization of stray field properties and their influence on spin dynamics.Comment: 16 pages, 10 figures, submitted to New Journal of Physic

Recherches sur l’immunisation anticlaveleuse I. — Sur la vaccination en un seul temps contre la clavelée et la fièvre charbonneuse, avec des antigènes vivants, associés et stabilisés

Delpy Louis-Pierre, Rafyi A., Chamsy H. Mir. Recherches sur l’immunisation anticlaveleuse : I. Sur la vaccination en un seul temps contre la clavelée et la fièvre charbonneuse avec des antigènes vivants, associés et stabilisés. In: Bulletin de l'Académie Vétérinaire de France tome 104 n°1, 1951. pp. 50-55

Pulse oximetry in the oesophagus

Pulse oximetry has been one of the most significant technological advances in clinical monitoring in the last two decades. Pulse oximetry is a non-invasive photometric technique that provides information about the arterial blood oxygen saturation (SpO(2)) and heart rate, and has widespread clinical applications. When peripheral perfusion is poor, as in states of hypovolaemia, hypothermia and vasoconstriction, oxygenation readings become unreliable or cease. The problem arises because conventional pulse oximetry sensors must be attached to the most peripheral parts of the body, such as finger, ear or toe, where pulsatile flow is most easily compromised. Since central blood flow may be preferentially preserved, this review explores a new alternative site, the oesophagus, for monitoring blood oxygen saturation by pulse oximetry. This review article presents the basic physics, technology and applications of pulse oximetry including photoplethysmography. The limitations of this technique are also discussed leading to the proposed development of the oesophageal pulse oximeter. In the majority, the report will be focused on the description of a new oesophageal photoplethysmographic/SpO(2) probe, which was developed to investigate the suitability of the oesophagus as an alternative monitoring site for the continuous measurement of SpO(2) in cases of poor peripheral circulation. The article concludes with a review of reported clinical investigations of the oesophageal pulse oximeter

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in drug-resistant cancer cells. Aimed to determine the role of GCS in tumor response to chemotherapy, a new mixed-backbone oligonucleotide (MBO-asGCS) with higher stability and efficiency has been generated to silence human GCS gene. MBO-asGCS was taken up efficiently in both drug-sensitive and drug-resistant cells, but it selectively suppressed GCS overexpression, and sensitized drug-resistant cells. MBO-asGCS increased doxorubicin sensitivity by 83-fold in human NCI/ADR-RES, and 43-fold in murine EMT6/AR1 breast cancer cells, respectively. In tumor-bearing mice, MBO-asGCS treatment dramatically inhibited the growth of multidrug-resistant NCI/ADR-RE tumors, decreasing tumor volume to 37%, as compared with scrambled control. Furthermore, MBO-asGCS sensitized multidrug-resistant tumors to chemotherapy, increasing doxorubicin efficiency greater than 2-fold. The sensitization effects of MBO-asGCS relied on the decreases of gene expression and enzyme activity of GCS, and on the increases of C18-ceramide and of caspase-executed apoptosis. MBO-asGCS was accumulation in tumor xenografts was greater in other tissues, excepting liver and kidneys; but MBO-asGCS did not exert significant toxic effects on liver and kidneys. This study, for the first time in vivo, has demonstrated that GCS is a promising therapeutic target for cancer drug resistance, and MBO-asGCS has the potential to be developed as an antineoplastic agent