AC Ehlis

AK Singh

AP Wand

AW Kooi van der

B Mouratidis

D Adamis

D Tsuzuki

DJ Meagher

DL Leslie

DT Delpy

H Nakanishi

H Tomioka

H Yokota

IS Chung

J Cohen

JL Rudolph

JR Maldonado

JS Saczynski

KJ Neufeld

LJ Brown

M Corbetta

M Ferrari

M Kameyama

M Okamoto

MA Pisani

ME Charlson

MJ Herrmann

P Ferenci

P Iversen

PT Trzepacz

R Rosenberg

R Takizawa

SE Petersen

SH Choi

SK Inouye

TG Fong

V Toronov

Z Tieges

Scientific Reports

English

Delirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syndrome. Functional near-infrared spectroscopy (fNIRS) is an optical topography system to measure changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex. We examined whether altered cortical brain activity in delirious patients with end stage liver disease (ESLD) is detected by fNIRS. We found that the [oxy-Hb] change during the verbal fluency task (VFT) was reduced in patients with ESLD compared with healthy controls (HC) in the prefrontal and bi-temporal regions. The [oxy-Hb] change during the sustained attention task (SAT) was elevated in patients with ESLD compared to HC in the prefrontal and left temporal regions. Notably, [oxy-Hb] change in the left dorsolateral prefrontal cortex during SAT showed a positive correlation with the severity of delirium. Our results suggest that [oxy-Hb] change in the prefrontal cortex during the sustained attention task measured with fNIRS might serve as a biological marker associated with delirium in ESLD patients.</p

Yoshimura, Atsushi

Goodson, Carrie

Johns, Jordan T

Towe, Maxwell M

Irvine, Esme S

Rendradjaja, Nada A

Max, Laura K

LaFlam, Andrew

Ledford, Emily C

Probert, Julia

Tieges, Zoë

Edwin, David H

MacLullich, Alasdair M J

Hogue, Charles W

Lindquist, Martin A

Gurakar, Ahmet

Neufeld, Karin J

Kamiya, Atsushi

Edinburgh Research Explorer

Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy:Associations with delirium

Delirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syndrome. Functional near-infrared spectroscopy (fNIRS) is an optical topography system to measure changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex. We examined whether altered cortical brain activity in delirious patients with end stage liver disease (ESLD) is detected by fNIRS. We found that the [oxy-Hb] change during the verbal fluency task (VFT) was reduced in patients with ESLD compared with healthy controls (HC) in the prefrontal and bi-temporal regions. The [oxy-Hb] change during the sustained attention task (SAT) was elevated in patients with ESLD compared to HC in the prefrontal and left temporal regions. Notably, [oxy-Hb] change in the left dorsolateral prefrontal cortex during SAT showed a positive correlation with the severity of delirium. Our results suggest that [oxy-Hb] change in the prefrontal cortex during the sustained attention task measured with fNIRS might serve as a biological marker associated with delirium in ESLD patients

Johns, Jordan

Towe, Maxwell

Irvine, Esme

Rendradjaja, Nada

Max, Laura

Ledford, Emily

Tieges, Zoe

Edwin, David

MacLullich, Alasdair

Hogue, Charles

Lindquist, Martin

Neufeld, Karin

ResearchOnline@GCU

Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: associations with delirium

AbstractDelirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syndrome. Functional near-infrared spectroscopy (fNIRS) is an optical topography system to measure changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex. We examined whether altered cortical brain activity in delirious patients with end stage liver disease (ESLD) is detected by fNIRS. We found that the [oxy-Hb] change during the verbal fluency task (VFT) was reduced in patients with ESLD compared with healthy controls (HC) in the prefrontal and bi-temporal regions. The [oxy-Hb] change during the sustained attention task (SAT) was elevated in patients with ESLD compared to HC in the prefrontal and left temporal regions. Notably, [oxy-Hb] change in the left dorsolateral prefrontal cortex during SAT showed a positive correlation with the severity of delirium. Our results suggest that [oxy-Hb] change in the prefrontal cortex during the sustained attention task measured with fNIRS might serve as a biological marker associated with delirium in ESLD patients.</jats:p

Atsushi Yoshimura

Carrie Goodson

Jordan T. Johns

Maxwell M. Towe

Esme S. Irvine

Nada A. Rendradjaja

Laura K. Max

Andrew LaFlam

Emily C. Ledford

Julia Probert

Zoë Tieges

David H. Edwin

Alasdair M. J. MacLullich

Charles W. Hogue

Martin A. Lindquist

Ahmet Gurakar

Karin J. Neufeld

Atsushi Kamiya

Crossref

Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium

https://researchonline.gcu.ac.uk/ws/files/32747919/s41598_017_10024_7.pdf

Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: associations with delirium

Abstract

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