Hydrogeological effects on terrestrial gravity measurements

For the 20 last years, terrestrial and satellite gravity measurements have reached such a precision that they allow for identification of the signatures from water storage fluctuations. In particular, hydrogeological effects induce significant time-correlated signature in the gravity time series. Gravity response to rainfall is a complex function of the local geologic and climatic conditions, e.g., rock porosity, vegetation, evaporation, and runoff rates. The gravity signal combines contributions from many geophysical processes, source separation being a major challenge. At the local scale and short-term, the associated gravimetric signatures often exceed the tectonic and GIA effects, and monitoring gravity changes is a source of information on local groundwater mass balance, and contributes to model calibrations. Some aquifer main characteristics can then be inferred by combining continuous gravity, geophysical and hydrogeological measurements. In Membach, Belgium, a superconducting gravimeter has monitored gravity continuously for more than 24 years. This long time series, together with 300 repeated absolute gravity measurements and environmental monitoring, has provided valuable information on the instrumental, metrological, hydrogeological and geophysical points of view. This has allowed separating the signal sources and monitoring partial saturation dynamics in the unsaturated zone, convective precipitation and evapotranspiration at a scale of up to 1 km², for signals smaller than 1 nm/s², equivalent to 2.5 mm of water. Based on this experience, another superconducting gravimeter was installed in 2014 in the karst zone of Rochefort, Belgium. In a karst area, where the vadose zone is usually thicker than in other contexts, combining gravity measurements at the surface and inside accessible caves is a way to separate the contribution from the unsaturated zone lying between the two instruments, from the saturated zone underneath the cave, and the common mode effects from the atmosphere or other regional processes. Those experiments contribute to the assessment of the terrestrial hydrological cycle, which is a major challenge of the geosciences associated with key societal issues: availability of freshwater, mitigation of flood hazards, or measurement of evapotranspiration

Hydrogeological effects on terrestrial gravity measurements

For the 20 last years, terrestrial and satellite gravity measurements have reached such a precision that they allow for identification of the signatures from water storage fluctuations. In particular, hydrogeological effects induce significant time-correlated signature in the gravity time series. Gravity response to rainfall is a complex function of the local geologic and climatic conditions, e.g., rock porosity, vegetation, evaporation, and runoff rates. The gravity signal combines contributions from many geophysical processes, source separation being a major challenge. At the local scale and short-term, the associated gravimetric signatures often exceed the tectonic and GIA effects, and monitoring gravity changes is a source of information on local groundwater mass balance, and contributes to model calibrations. Some aquifer main characteristics can then be inferred by combining continuous gravity, geophysical and hydrogeological measurements. In Membach, Belgium, a superconducting gravimeter has monitored gravity continuously for more than 24 years. This long time series, together with 300 repeated absolute gravity measurements and environmental monitoring, has provided valuable information on the instrumental, metrological, hydrogeological and geophysical points of view. This has allowed separating the signal sources and monitoring partial saturation dynamics in the unsaturated zone, convective precipitation and evapotranspiration at a scale of up to 1 km², for signals smaller than 1 nm/s², equivalent to 2.5 mm of water. Based on this experience, another superconducting gravimeter was installed in 2014 in the karst zone of Rochefort, Belgium. In a karst area, where the vadose zone is usually thicker than in other contexts, combining gravity measurements at the surface and inside accessible caves is a way to separate the contribution from the unsaturated zone lying between the two instruments, from the saturated zone underneath the cave, and the common mode effects from the atmosphere or other regional processes. Those experiments contribute to the assessment of the terrestrial hydrological cycle, which is a major challenge of the geosciences associated with key societal issues: availability of freshwater, mitigation of flood hazards, or measurement of evapotranspiration

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Efficiency of infrared laser treatment examined in the healing of bedsores.

Journal Articleinfo:eu-repo/semantics/publishe

Maximizing the delivery of intraperitoneal therapy while minimizing drug toxicity and maintaining quality of life.

This decade has witnessed three large randomized trials (SWOG 8501/GOG 104, GOG 114, and GOG 172) clearly showing the advantages of intraperitoneal (IP) chemotherapy over systemic/intravenous therapy in treating selected patients with advanced stage ovarian cancer. Despite showing an impressive increase in median progression-free survival and median overall survival, complications in IP chemotherapy delivery and drug-related toxicities reported in these studies have hindered widespread acceptance and implementation of first-line IP therapy. Some of these complications and drug-related toxicities are treatment-limiting and need special attention. Success of IP therapy as a first-line choice of treatment is dependent upon ideal patient selection, effective delivery of appropriate doses of chemotherapy agents to the tumor site, and efficient management of complications. With proper orientation and instruction in IP catheter placement and patient management, these obstacles can be overcome, allowing for successful administration of IP therapies. This review article discusses clinical approaches to maximize the delivery of IP therapy while minimizing catheter complications. Mitigating drug toxicities with the use of cytoprotectants such as amifostine and preventing infection with the use of agents, such as amifostine and pegfilgrastim, are discussed in detail.Journal ArticleResearch Support, Non-U.S. Gov'tReviewinfo:eu-repo/semantics/publishe

Le médecin généraliste en milieu rural et la dépression du sujet âgé (prise en charge initiale et suivi de l'évolution)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Human monoclonal antibodies: new approaches and perspectives in cancer.

Journal Articleinfo:eu-repo/semantics/publishe

Neutropenia associated with excess of T cell lymphocytes

Case ReportsJournal ArticleFLWINinfo:eu-repo/semantics/publishe

Relative effects of carminomycin (CMM), adriamycin (ADM) and daunomycin (DNM) in normal myeloid and leukemic clonogenic assays

SCOPUS: ar.jinfo:eu-repo/semantics/publishe