Static SU(3) potentials for sources in various representations

The potentials and string tensions between static sources in a variety of representations (fundamental, 8, 6, 15-antisymmetric, 10, 27 and 15-symmetric) have been computed by measuring Wilson loops in pure gauge SU(3). The simulations have been done primarily on anisotropic lattices, using a tadpole improved action improved to O(a_{s}^4). A range of lattice spacings (0.43 fm, 0.25 fm and 0.11 fm) and volumes ($8^3\times 24$, $10^3 \times 24$, $16^3 \times 24$ and $18^3 \times 24$) has been used in an attempt to control discretization and finite volume effects. At intermediate distances, the results show approximate Casimir scaling. Finite lattice spacing effects dominate systematic error, and are particularly large for the representations with the largest string tensions.Comment: Version to appear in PR

ANALYSIS OF A TWO LACTATION TARGET ANIMAL SAFETY STUDY OF SOMIDOBOVE SUSTAINED RELEASE INJECTION IN MULTIPAROUS DAIRY COWS

An overview is given of the primary basis for the scientific inference that somidobove sustained release injection is safe for multiparous dairy cows. The process of analysis and interpretation of the voluminous data collected from a target animal safety study which started with 28 cows and lasted two lactations is described. This was a repeated measures study with most of 60 variables being measured or summarized every 28 days resulting in approximately 1500 measurements per cow. The statistical analysis was designed to screen the variables for biological change caused by treatment and consisted of a univariate analysis of variance for repeated measures data both within a lactation and across two lactations. Graphs of least squares means with error bounds and p-value plots of ANOVA p-values helped communicate statistical findings. A cross disciplinary approach interpreted analyses and arrived at inferences

Vacuum replicas in QCD

The properties of the vacuum are addressed in the two- and four-dimensional quark models for QCD. It is demonstrated that the two-dimensional QCD ('t Hooft model) possesses only one possible vacuum state - the solution to the mass-gap equation, which provides spontaneous breaking of the chiral symmetry (SBCS). On the contrary, the four-dimensional theory with confinement modeled by the linear potential supplied by the Coulomb OGE interaction, not only has the chirally-noninvariant ground vacuum state, but it possesses an excited vacuum replica, which also exhibits SBCS and can realize as a metastable intermediate state of hadronic systems. We discuss the influence of the latter on physical observables as well as on the possibility to probe the vacuum background fields in QCD.Comment: RevTeX4, 26 pages, 8 EPS figures, extended references, corrected some typos, to appear in Phys.Rev.

k-strings and baryon vertices in SU(N) gauge theories

It is pointed out that the sine law for the k-string tension emerges as the critical threshold below which the spatial Z_N symmetry of the static baryon potential is spontaneously broken. This result applies not only to SU(N) gauge theories, but to any gauge system with stable k-strings admitting a baryon vertex made with N sources in the fundamental representation. Some simple examples are worked out.Comment: 4 pages, 4 figures, v2: reference added, v3: comments and references adde

Second language learning in older adults modulates Stroop task performance and brain activation

IntroductionNumerous studies have highlighted cognitive benefits in lifelong bilinguals during aging, manifesting as superior performance on cognitive tasks compared to monolingual counterparts. Yet, the cognitive impacts of acquiring a new language in older adulthood remain unexplored. In this study, we assessed both behavioral and fMRI responses during a Stroop task in older adults, pre- and post language-learning intervention.MethodsA group of 41 participants (age:60–80) from a predominantly monolingual environment underwent a four-month online language course, selecting a new language of their preference. This intervention mandated engagement for 90 minutes a day, five days a week. Daily tracking was employed to monitor progress and retention. All participants completed a color-word Stroop task inside the scanner before and after the language instruction period.ResultsWe found that performance on the Stroop task, as evidenced by accuracy and reaction time, improved following the language learning intervention. With the neuroimaging data, we observed significant differences in activity between congruent and incongruent trials in key regions in the prefrontal and parietal cortex. These results are consistent with previous reports using the Stroop paradigm. We also found that the amount of time participants spent with the language learning program was related to differential activity in these brain areas. Specifically, we found that people who spent more time with the language learning program showed a greater increase in differential activity between congruent and incongruent trials after the intervention relative to before.DiscussionFuture research is needed to determine the optimal parameters for language learning as an effective cognitive intervention for aging populations. We propose that with sufficient engagement, language learning can enhance specific domains of cognition such as the executive functions. These results extend the understanding of cognitive reserve and its augmentation through targeted interventions, setting a foundation for future investigations

k-string tensions in SU(N) gauge theories

In the context of four-dimensional SU(N) gauge theories, we study the spectrum of the confining strings. We compute, for the SU(6) gauge theory formulated on a lattice, the three independent string tensions sigma_k related to sources with Z_N charge k=1,2,3, using Monte Carlo simulations. Our results, whose uncertainty is approximately 2% for k=2 and 4% for k=3, are consistent with the sine formula sigma_k/sigma = sin(k pi/N) / \sin(pi/N) for the ratio between sigma_k and the standard string tension sigma, and show deviations from the Casimir scaling. The sine formula is known to emerge in supersymmetric SU(N) gauge theories and in M-theory. We comment on an analogous behavior exhibited by two-dimensional SU(N)xSU(N) chiral models.Comment: version accepted for publication in Phys Rev D (Rap Comm

Color superconductivity, Z_N flux tubes and monopole confinement in deformed N=2* super Yang-Mills theories

We study the Z_N flux tubes and monopole confinement in deformed N=2* super Yang-Mills theories. In order to do that we consider an N=4 super Yang-Mills theory with an arbitrary gauge group G and add some N=2, N=1 and N=0 deformation terms. We analyze some possible vacuum solutions and phases of the theory, depending on the deformation terms which are added. In the Coulomb phase for the N=2* theory, G is broken to U(1)^r and the theory has monopole solutions. Then, by adding some deformation terms, the theory passes to the Higgs or color superconducting phase, in which G is broken to its center C_G. In this phase we construct the Z_N flux tubes ansatz and obtain the BPS string tension. We show that the monopole magnetic fluxes are linear integer combinations of the string fluxes and therefore the monopoles can become confined. Then, we obtain a bound for the threshold length of the string-breaking. We also show the possible formation of a confining system with 3 different monopoles for the SU(3) gauge group. Finally we show that the BPS string tensions of the theory satisfy the Casimir scaling law.Comment: 18 pages, 2 figures, typo corrections. Version to appear in Phys. Rev.

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019

Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively. Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries

Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

BACKGROUND: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. METHODS: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. FINDINGS: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. INTERPRETATION: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively. FUNDING: The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38)