Radio sur fibre pour un réseau local domestique millimétrique

National audienceLe projet FUI ORIGIN (Optical-Radio Infrastructure for Gigabit/s Indoor Networks) adresse le marché du Réseau Local Domestique pour lequel il propose une nouvelle infrastructure à très haut débit associant un câblage à fibre optique avec une diffusion radio 60GHz. Les premiers tests de cette infrastructure ont donné des résultats probants : un lien Radio sur Fibre en fréquence intermédiaire étendant la portée d'une transmission radio millimétrique est ici proposé et caractérisé complètement en termes d'EVM. Ce concept est validé par l'utilisation de produits commerciaux Wireless HD. Les études se poursuivent pour intégrer les systèmes optique-microondes en utilisant des composants bas coûts et innovants, comme les phototransistors SiGe/Si et des VCSEL analogiques

lncRNA requirements for mouse acute myeloid leukemia and normal differentiation

A substantial fraction of the genome is transcribed in a cell type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here we systematically characterize transcriptional dynamics during hematopoiesis and in hematological malignancies. Our analysis of annotated and de novo assembled lncRNAs showed many are regulated during differentiation and mis-regulated in disease. We assessed lncRNA function via an in vivo RNAi screen in a model of acute myeloid leukemia. This identified several lncRNAs essential for leukemia maintenance, and found that a number act by promoting leukemia stem cell signatures. Leukemia blasts show a myeloid differentiation phenotype when these lncRNAs were depleted, and our data indicates that this effect is mediated via effects on the c-MYC oncogene. Bone marrow reconstitutions showed that a lncRNA expressed across all progenitors was required for the myeloid lineage, whereas the other leukemia-induced lncRNAs were dispensable in the normal setting

Origin : a 60 GHz radio-over-fiber home area network project

International audience

A digital intake approach in specialized mental health care : study protocol of a cluster randomised controlled trial

Background: Enhancing patient participation is becoming increasingly important in mental health care as patients use to have a dependent, inactive role and nonadherence to treatment is a regular problem. Research shows promising results of initiatives stimulating patient participation in partnership with their clinicians. However, few initiatives targeting both patients’ and clinicians’ behaviour have been evaluated in randomised trials (RCT). Therefore, in GGz Breburg, a specialized mental health institution, a digital intake approach was developed aimed at exploring treatment needs, expectations and preferences of patients intended to prepare patients for the intake consultations. Subsequently, patients and clinicians discuss this information during intake consultations and make shared decisions about options in treatment. The aim of this trial is to test the efficacy of this new digital intake approach facilitated by Routine Outcome Monitoring (ROM), peer support and training of clinicians as compared to the intake as usual. The primary outcome is decisional conflict about choices in treatment. Secondary outcomes focus on patient participation, shared decision making, working alliance, adherence to treatment and clinical outcomes. Methods: This article presents the study protocol of a cluster-randomised controlled trial in four outpatient departments for adults with depression, anxiety and personality disorders, working in two different regions. Randomisation is done between two similar intake-teams within each department. In the four intervention teams the new intake approach is implemented. The four control teams apply the intake as usual and will implement the new approach after the completion of the study. In total 176 patients are projected to participate in the study. Data collection will be at baseline, and at two weeks and two months after the intake. Discussion: This study will potentially demonstrate the efficacy of the new digital intake approach in mental health care in terms of the primary outcome the degree of decisional conflict about choices in treatment. The findings of this study may contribute to the roll out of such eHealth initiatives fostering patient involvement in decision making about their treatment

Dogma derailed: the many influences of RNA on the genome

Epigenetic control of gene expression is a critical component of transcriptional regulation. Remarkably, the deposition of epigenetic modifications is often guided by noncoding RNAs. Although noncoding RNAs have been most often implicated in posttranscriptional gene silencing, these molecules are now emerging as critical regulators of gene expression and genomic stability at the transcriptional level. Here, we review recent efforts to understand the mechanisms by which RNA controls the expression or content of DNA. We discuss the role of both small RNAs and long noncoding RNAs in directing chromatin changes through histone modifications and DNA methylation. Furthermore, we highlight the function of RNA in mediating DNA cleavage during genome rearrangements and pathogen defense. In understanding the mechanisms of RNA control over DNA, the power of RNA may one day be harnessed to impact gene expression in a therapeutic setting

Intrabiliary rupture of hepatic hydatid kyst: endoscopic retrograde cholangiography diagnosis and treatment

Nous rapportons l'observation, chez un homme de nationalité turque âgé de 32 ans, d'une angiocholite par rupture d'un kyste hydatique du foie dans les voies biliaires. Un traitement associant une sphinctérotomie endoscopique et un drainage nasobiliaire à permis chez cet homme, porteur d'une polykystose hépato-rénale, la normalisation clinico-biologique, sérologique et la régression de l'image kystique. Ce traitement endoscopique exclusif, facilement réalisable en urgence, devrait permettre de surseoir à la chirurgie plus morbide dans ce type de complication, particulièrement en cas de pathologie hépatigue associé