International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Background: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document. Methods: ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results: ICAR-Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion: The ICAR-Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment

Chronic Rhinosinusitis: Does Allergy Play a Role?

A few chronic rhinosinusitis (CRS) variants have demonstrated a strong association with environmental allergy, including allergic fungal rhinosinusitis (AFRS) and central compartment atopic disease (CCAD). However, the overall relationship between CRS and allergy remains poorly defined. The goal of this review is to evaluate the relationship between CRS and allergy with a focus on specific CRS variants

Geochemistry and geochronology of apatite and zircon from MtAp and IOCG deposits, Atacama desert, Chile

Trabajo presentado en el XIX Congreso Peruano de Geología, celebrado en Lima (Perú), del 23 al 26 de septiembre de 2018The Chilean Iron Belt in the Atacama Desert offers a unique opportunity to investigate both Iron Oxide Copper Gold (IOCG) and Magnetite Apatite (MtAp) deposits in a geographically concentrated setting. This unique setting allows for the comparison of apatite and zircon between MtAp and IOCG deposits to better constrain differences and similarities between age, magma source, and fluid composition associated with the different deposits types. Zircon from the Cenozoic El Laco and apatite from El Laco and Incahuasi MtAp deposit in the Central Volcanic Zone are also included for comparison. Major and minor elements in both minerals were analyzed in situ by EPMA, while trace element compositions and U-Pb ratios were measured in situ by LA-ICPMS. Sm-Nd and Lu-Hf isotopes were measured in situ by LA-MC-ICPMS in the same regions as the trace elements and U-Pb. U-Pb geochronology of the El Laco zircon samples were done by SIMS due to their young age and their high U/Pb ratios. Ore apatites from the MtAp deposits contain 0.3-3 REE wt%, multiple phases of Cl-fluid alteration coupled with S and REE enrichment, and a general enrichment in LREE and MREE compared to their respective host. ¿ Nd values are negative with respect to the Cenozoic MtAp deposits and positive with respect to the Cretaceous MtAp deposits, indicating that crustal contamination may not be a necessary process in the formation of MtAp deposits. Future zircon analysis will better constrain age, magma source, and oxidation state of host and ore samples in both deposit types.Peer reviewe