The Varied Character of the Des Moines River Valley in Central Iowa

The drainage system on the Des Moines River is quite varied between Humboldt and Des Moines. The variation in drainage characters is highlighted on a map prepared from aerial photographs and topographic sheets. The northern part of this area is associated with the Mankato drift sheet and is characterized by poorly developed, non-integrated drainage. The central part of the drainage system in Boone County flows across the Cary ground moraine. In this area the tributaries are short, intermittent, and deep, and appear as gullies and washes. Just south of Des Moines, the drainage makes another sharp change, and in this area is associated with the Kansan drift. It is well integrated and featured by a relatively small number of far-reaching primary tributaries. It seems to be more than coincidental that the change in character of the drainage is so closely associated with the relative ages of the drift sheets comprising the drift plain

Red blood cell invasion by Plasmodium vivax: Structural basis for DBP engagement of DARC

Plasmodium parasites use specialized ligands which bind to red blood cell (RBC) receptors during invasion. Defining the mechanism of receptor recognition is essential for the design of interventions against malaria. Here, we present the structural basis for Duffy antigen (DARC) engagement by P. vivax Duffy binding protein (DBP). We used NMR to map the core region of the DARC ectodomain contacted by the receptor binding domain of DBP (DBP-RII) and solved two distinct crystal structures of DBP-RII bound to this core region of DARC. Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC binding by DBP-RII. Two DBP-RII molecules sandwich either one or two DARC ectodomains, creating distinct heterotrimeric and heterotetrameric architectures. The DARC N-terminus forms an amphipathic helix upon DBP-RII binding. The studies reveal a receptor binding pocket in DBP and critical contacts in DARC, reveal novel targets for intervention, and suggest that targeting the critical DARC binding sites will lead to potent disruption of RBC engagement as complex assembly is dependent on DARC binding. These results allow for models to examine inter-species infection barriers, Plasmodium immune evasion mechanisms, P. knowlesi receptor-ligand specificity, and mechanisms of naturally acquired P. vivax immunity. The step-wise binding model identifies a possible mechanism by which signaling pathways could be activated during invasion. It is anticipated that the structural basis of DBP host-cell engagement will enable development of rational therapeutics targeting this interaction

Modelling of corrosion-induced cover cracking in reinforced concrete by an embedded cohesive crack finite element

Corrosion of a reinforcement bar leads to expansive pressure on the surrounding concrete that provokes internal cracking and, eventually, spalling and delamination. Here, an embedded cohesive crack 2D finite element is applied for simulating the cracking process. In addition, four simplified analytical models are introduced for comparative purposes. Under some assumptions about rust properties, corrosion rate, and particularly, the accommodation of oxide products within the open cracks generated in the process, the proposed FE model is able to estimate time to surface cracking quite accurately. Moreover, emerging cracking patterns are in reasonably good agreement with expectations. As a practical case, a prototype application of the model to an actual bridge deck is reported

Winter Time Concentrations and Size Distribution of Bioaerosols in Different Residential Settings in the UK

The total concentration and size distribution of bioaerosols in three different types of housing (single room in shared accommodation [type I], single bedroom flat in three-storey building [type II] and two- or threebedroom detached houses [type III]) was assessed during the winter. This research was an extension of a previous study carried out in the summer. The measurement campaign was undertaken in winter 2008 and 30 houses were sampled. Samples were taken from kitchens, living rooms, corridors (only in housing type I) and outdoors with an Anderson 6 stage viable impactor. In housing type I, the total geometric mean concentration was highest in the corridor for both bacteria and fungi (3,171 and 1,281 CFU/m3, respectively). In type II residences, both culturable bacteria and fungi were greatest in the living rooms (3,487 and 833 CFU/m3, respectively). The living rooms in type III residences had largest number of culturable bacteria (1,361 CFU/m3) while fungi were highest in kitchens (280 CFU/m3). The concentrations of culturable bacteria and fungi were greater in mouldy houses than non-mouldy houses. A considerable variation was seen in the size distribution of culturable bacteria in type I residences compared to types II and III. For all housing types more than half of culturable bacterial and fungal aerosol were respirable (<4.7 μm) and so have the potential to penetrate into lower respiratory system. Considerable variation in concentration and size distribution within different housing types in the same geographical region highlights the impact of differences in design, construction, use and management of residential built environment on bioaerosols levels and consequent varied risk of population exposure to airborne biological agents. © Springer Science+Business Media B.V. 2012

Perturbed Angular Correlation Study of Fe/Cr (100) and Fe/Co (1-10) Multilayers

Recently we completed the very first and detailed perturbed angular correlation investigation on MBE-grown very thin film multilayers. The present paper aims to show that otherwise rather unaccessible but unique information on the (interface) magnetism could be obtained. For the Fe/Cr(1 0 0) multilayer system we observe, below a critical Cr thickness of 5.0 nm, a collapse of the spin-density-wave ordering in chromium. While the magnetization in the Fe-layer is in-plane, the Cr magnetization in thicker layers is out-of-plane. In the Fe/Co (1 -1 0) system, the observation of transferred magnetic hyperfine field satellites and their temperature dependence leads to the determination of an oscillating magnetic moment profile at the Fe/Co interface as well as a structure model for the superlattice

Perturbed Angular Correlation Study of Fe/Cr (1 0 0) and Fe/Co (1 -1 0) Multilayers

Recently we completed the very first and detailed perturbed angular correlation investigation on MBE-grown very thin film multilayers. The present paper aims to show that otherwise rather unaccessible but unique information on the (interface) magnetism could be obtained. For the Fe/Cr(1 0 0) multilayer system we observe, below a critical Cr thickness of 5.0 nm, a collapse of the spin-density-wave ordering in chromium. While the magnetization in the Fe-layer is in-plane, the Cr magnetization in thicker layers is out-of-plane. In the Fe/Co (1 -1 0) system, the observation of transferred magnetic hyperfine field satellites and their temperature dependence leads to the determination of an oscillating magnetic moment profile at the Fe/Co interface as well as a structure model for the superlattice