How has selection for residual feed intake (RFI) affected the grow-finish pig’s ability to cope with stress?

Feed is the largest cost in pork production; therefore, improving feed efficiency can increase producer profitability. Furthermore improved feed efficiency can support industry competitiveness, decrease the demand on global feed resources, and complement environmental sustainability. Genetically, selective breeding for residual feed intake (RFI) shows promise in meeting these increased demands. However, it is important to balance the benefits of feed efficiency selection with the pig’s ability to cope with stress and its welfare. Therefore, this factsheet will discuss physiological and behavioral stress research on swine selected on the basis of RFI

Improved nutrient digestibility and retention partially explains feed efficiency gains in pigs selected for low residual feed intake

Residual feed intake (RFI) is a unique measure of feed efficiency (FE) and an alternative to traditional measures. The RFI is defined as the difference between the actual feed intake of a pig and its expected feed intake based on a given amount of growth and backfat. Therefore, selecting pigs with a low RFI (LRFI) results in a more feed-efficient animal for a given rate of growth. Our objective was to determine the extent to which apparent total tract digestibility of nutrients and energy use and retention may explain FE differences between pigs divergently selected for LRFI or high RFI (HRFI). After 7 generations of selection, 12 HRFI and 12 LRFI pigs (62 ± 3 kg BW) were randomly assigned to metabolism crates. Pigs had free access to a standard diet based on corn (Zea mays) and soybean (Glycine max) meal containing 0.4% TiO2, an exogenous digestibility marker. After a 7-d acclimation, total urine and feces were collected for 72 h. Nutrient and energy digestibility, P digestibility, and N balance were then measured and calculated to determine differences between the RFI lines. As expected, ADFI was lower (2.0 vs. 2.6 kg; P \u3c 0.01), ADG did not differ, and FE was higher in the LRFI (P \u3c 0.001) compared to the HRFI pigs. The digestibility values for DM (87.3 vs. 85.9%), N (88.3 vs. 86.1%), and GE (86.9 vs. 85.4%) were higher (P ≤ 0.003) in the LRFI vs. HRFI pigs, respectively. The DE (16.59 vs. 16.32 MJ/kg DM) and ME (15.98 vs. 15.72 MJ/kg DM) values were also greater (P \u3c 0.001) in LRFI pigs. When correcting for ADFI, P digestibility did not differ between the lines. However, the LRFI pigs tended to have improved N retention (P = 0.08) compared to HRFI pigs (36.9 vs. 32.1 g/d). In conclusion, the higher energy and nutrient digestibility, use, and retention may partially explain the superior FE seen in pigs selected for LRFI

Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration

Mutations in NIPBL are the most frequent cause of Cornelia de Lange syndrome (CdLS), a developmental disorder encompassin

How has selection for residual feed intake (RFI) affected nursery and finisher pig’s feeding behavior and performance?

Feed is the largest cost in pork production; therefore, improving finisher pig feed efficiency can increase producer profitability. Improving feed efficiency can support industry competitiveness, decrease the demand on global feed resources, and complement environmental sustainability. Selective breeding for residual feed intake (RFI) shows promise in meeting these increased demands. However, it is important to balance the benefits of feed efficiency selection with the pig’s feeding behavior and performance. Therefore, this factsheet will discuss feeding behavior and performance research on RFI selection conducted at Iowa State University

Dwelling, house and home: towards a home-led perspective on dementia care

“Home” is well known from everyday experience, plays a crucial role in all kinds of narratives about human life, but is hardly ever systematically dealt with in the philosophy of medicine and health care. The notion of home is ambiguous, is often used in a metaphorical way, and is closely related to concepts such as house and dwelling. In this paper the phenomenon of home is explored by means of some phenomenological writings of Heidegger, Bollnow, Bachelard and Levinas. Common in their views is that being at home and dwelling mean something more fundamental than an activity we do along with other activities, such as working and travelling. Dwelling, building a house and being at home are fundamental aspects of human existence. Being human is dwelling. While exploring the relevance of this phenomenological perspective for medical theory and practice, the focus is on the care of people suffering from dementia

Dynamic rubidium-82 PET/CT as a novel tool for quantifying hemodynamic differences in renal blood flow using a one-tissue compartment model

Purpose: Assessing renal perfusion in-vivo is challenging and quantitativeinformation regarding renal hemodynamics is hardly incorporated in medicaldecision-making while abnormal renal hemodynamics might play a crucial rolein the onset and progression of renal disease. Combining physiological stimuliwith rubidium-82 positron emission tomography/computed tomography (82 RbPET/CT) offers opportunities to test the kidney perfusion under various condi-tions. The aim of this study is: (1) to investigate the application of a one-tissuecompartment model for measuring renal hemodynamics with dynamic 82 RbPET/CT imaging, and (2) to evaluate whether dynamic PET/CT is sensitiveto detect differences in renal hemodynamics in stress conditions compared toresting state.Methods: A one-tissue compartment model for the kidney was applied to car-diac 82 Rb PET/CT scans that were obtained for ischemia detection as part ofclinical care. Retrospective data, collected from 17 patients undergoing dynamicmyocardial 82 Rb PET/CT imaging in rest, were used to evaluate various CT-based volumes of interest (VOIs) of the kidney. Subsequently, retrospectivedata, collected from 10 patients (five impaired kidney functions and five controls)undergoing dynamic myocardial 82 Rb PET/CT imaging, were used to evaluateimage-derived input functions (IDIFs), PET-based VOIs of the kidney, extractionfractions, and whether dynamic 82 Rb PET/CT can measure renal hemodynam-ics differences using the renal blood flow (RBF) values in rest and after exposureto adenosine pharmacological stress.Results: The delivery rate (K1 ) values showed no significant (p = 0.14) differ-ence between the mean standard deviation (SD) K1 values using one CT-basedVOI and the use of two, three, and four CT-based VOIs, respectively 2.01(0.32),1.90(0.40), 1.93(0.39), and 1.94(0.40) mL/min/mL. The ratio between RBF inrest and RBF in pharmacological stress for the controls were overall significantlylower compared to the impaired kidney function group for both PET-based delin-eation methods (region growing and iso-contouring), with the smallest medianinterquartile range (IQR) of 0.40(0.28–0.66) and 0.96(0.62–1.15), respectively(p </p

The influence of 'significant others' on persistent back pain and work participation: a qualitative exploration of illness perceptions

Background Individual illness perceptions have been highlighted as important influences on clinical outcomes for back pain. However, the illness perceptions of 'significant others' (spouse/partner/close family member) are rarely explored, particularly in relation to persistent back pain and work participation. The aim of this study was to initiate qualitative research in this area in order to further understand these wider influences on outcome. Methods Semi-structured interviews based on the chronic pain version of the Illness Perceptions Questionnaire-Revised were conducted with a convenience sample of UK disability benefit claimants, along with their significant others (n=5 dyads). Data were analysed using template analysis. Results Significant others shared, and perhaps further reinforced, claimants' unhelpful illness beliefs including fear of pain/re-injury associated with certain types of work and activity, and pessimism about the likelihood of return to work. In some cases, significant others appeared more resigned to the permanence and negative inevitable consequences of the claimant's back pain condition on work participation, and were more sceptical about the availability of suitable work and sympathy from employers. In their pursuit of authenticity, claimants were keen to stress their desire to work whilst emphasising how the severity and physical limitations of their condition prevented them from doing so. In this vein, and seemingly based on their perceptions of what makes a 'good' significant other, significant others acted as a 'witness to pain', supporting claimants' self-limiting behaviour and statements of incapacity, often responding with empathy and assistance. The beliefs and responses of significant others may also have been influenced by their own experience of chronic illness, thus participants lives were often intertwined and defined by illness. Conclusions The findings from this exploratory study reveal how others and wider social circumstances might contribute both to the propensity of persistent back pain and to its consequences. This is an area that has received little attention to date, and wider support of these findings may usefully inform the design of future intervention programmes aimed at restoring work participation

Adjuvant platinum-based chemotherapy in radically resected adrenocortical carcinoma: a cohort study

Background After radical resection, patients with adrenocortical carcinoma (ACC) frequently experience recurrence and, therefore, effective adjuvant treatment is urgently needed. The aim of the study was to investigate the role of adjuvant platinum-based therapy. Methods In this retrospective multicentre cohort study, we identified patients treated with adjuvant platinum-based chemotherapy after radical resection and compared them with patients without adjuvant chemotherapy. Recurrence-free and overall survival (RFS/OS) were investigated in a matched group analysis and by applying a propensity score matching using the full control cohort (n = 268). For both approaches, we accounted for immortal time bias. Results Of the 31 patients in the platinum cohort (R0 n = 25, RX n = 4, R1 n = 2; ENSAT Stage II n = 11, III n = 16, IV n = 4, median Ki67 30%, mitotane n = 28), 14 experienced recurrence compared to 29 of 31 matched controls (median RFS after the landmark at 3 months 17.3 vs. 7.3 months; adjusted HR 0.19 (95% CI 0.09-0.42; P < 0.001). Using propensity score matching, the HR for RFS was 0.45 (0.29-0.89, P = 0.021) and for OS 0.25 (0.09-0.69; P = 0.007). Conclusions Our study provides the first evidence that adjuvant platinum-based chemotherapy may be associated with prolonged recurrence-free and overall survival in patients with ACC and a very high risk for recurrence.Clinical epidemiolog