Hooking in, Activating and Extending: An Institutional Ethnography of the Family Violence Project of the Waterloo Region

Domestic violence (DV) is a significant social issue requiring a thoughtful and dedicated response. At present, many social service agencies and governmental bodies have a responsibility to provide a response to DV. Increasingly, innovative service delivery models are being used to construct more coherent responses to the violence. One such model, originates from the United States is entitled the Family Justice Centre model. This model of service delivery consists of the agencies responding to DV residing within the same building. The goal of this model is to improve the access to service for victims and to improve collaborative efforts between organizations in response to DV. In Ontario, Canada, the Family Violence Project of the Waterloo Region (FVP) is the first co-located DV model of service delivery. Comprised of twelve partners from the Criminal Justice System (CJS) and the non-profit sector, the FVP was initially designed to streamline services to victims and provide one-stop service provision. A growing body of research suggests that victims benefit from receiving service from the FVP model of service delivery. However, little is known about how the work is accomplished within these co-located models. Using Institutional Ethnography (IE), as developed by Dorothy Smith (1999), this research explores the textually-mediated landscape of the FVP to understand work processes and social relations. By using IE as a method of inquiry, a model of a community-based response to DV is revealed that establishes the powerful role of the CJS in identifying and assessing risk using risk assessing tools. The sharing of risk documents by the core CJS agencies activates other non-core CJS partners and extends the overall response to non-CJS partners in the community. The overall effect is the creation of a web of surveillance where the CJS is provided with information regarding families by various FVP partner agencies at various stages of intervention. The recommendations arising from this research include expanding the research on the use of multi-agency, co-located service delivery models in Canada in response to DV. Future research should also include an examination into the experiences of DV victims accessing service from these co-located models. Finally, future research is needed to understand the pathways to service of men who use violence in their relationships to improve their visibility within these service response models

Traversing probe Patent

Flow meter for measuring stagnation pressure in boundary layer around high speed flight vehicl

Protein level for heifers on winter bluestem pasture

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Planning at the Interface of Nature and Culture: Theory, Methods, and Identification of Cultural Landscapes in the Townships of Woolwich and Wellesley

Planning for cultural landscapes requires the inclusion of the public in the decision-making process. Yet, how to include the public in a meaningful way remains poorly understood, especially for rural areas. This study explores the basis for public participation in cultural landscape planning through a critical review of both cultural landscape and communicative planning theory to consider how these two bodies of theory may function together to guide participatory cultural landscape planning. The study also includes a review of cultural landscape conservation research and practice in the province of Ontario, Canada, as well as in Europe. It is found that that, despite policy stipulating that the public ought to be involved, cultural landscape research and practice has only begun to address the challenges of public participation. Cultural ecosystem services (CES) literature, however, does address similar challenges in the context of ecosystem planning. In order to assess the applicability of CES methods for the identification of cultural landscapes, four participatory methods informed by that literature were used to identify candidate cultural heritage landscapes in the Townships of Woolwich and Wellesley, in southwestern Ontario, Canada. Through the use of interviews, focus groups, photo-voice, and a web-based survey, each with associated mapping exercises, 122 participants collaborated to identify areas of shared cultural heritage value. We found that valued areas were not spread randomly across the landscape, but instead were aggregated around certain landscape features. After community members participated in a method, they were asked to complete an evaluation survey. Through that instrument, it was found that focus groups had the most favourable experiences of social learning and stated behavioural changes, while the web-based survey was most favourably rated for application in other planning initiatives. Although each of the methods had its merits, it was found that interviews were indispensable for gaining an understanding of what it means to dwell in the landscape. Through that method, cultural and individual barriers to participatory cultural landscape identification were identified, and, moreover, it provided the information to enable consideration of the negative potentialities of designating cultural landscapes for unique communities that reside in or have a stake in the study area

Teacher Attitude Toward Consumer Issues and the Affect upon Consumer Education Units

Home Economics Educatio

Book Review: Lehmann, P., & Simmons, C. (2009). Strength-based batterer intervention: A new paradigm in ending family violence. New York: Springer Publishing Company.

Working with men who use violence against their partners is difficult and challenging work. As a field of practice, working with this population is growing and expanding on a continual basis. Historically, the mindset regarding working with men who abuse was quite narrow and there was little hope for change. The medical model would suggest that the prognosis for change was poor. For a long time, and some would suggest this pattern still continues, groups for men who abuse their partners were run along very narrow lines as well. For the past 20 years the primary model of ‘batterer intervention program’ (BIP) was the model developed in Duluth Minnesota. This model involved a mixture of the presentation of psycho-educational material in conjunction with a feminist analysis of violence against women. The Duluth model has remained the centerpiece of many programs throughout the United States and Canada

AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells

Chronic myeloid leukemia (CML) represents the first human malignancy successfully treated with a tyrosine kinase inhibitor (TKI; imatinib). However, early relapses and the emergence of imatinib-resistant disease are problematic. Evidence suggests that imatinib and other inhibitors may not effectively eradicate leukemic stem/progenitor cells, and that combination therapy directed to complimentary targets may improve treatment. Abelson helper integration site 1 (Ahi-1)/AHI-1 is a novel oncogene that is highly deregulated in CML stem/progenitor cells where levels of BCR-ABL transcripts are also elevated. Here, we demonstrate that overexpression of Ahi-1/AHI-1 in murine and human hematopoietic cells confer growth advantages in vitro and induce leukemia in vivo, enhancing effects of BCR-ABL. Conversely, RNAi-mediated suppression of AHI-1 in BCR-ABL–transduced lin−CD34+ human cord blood cells and primary CML stem/progenitor cells reduces their growth autonomy in vitro. Interestingly, coexpression of Ahi-1 in BCR-ABL–inducible cells reverses growth deficiencies exhibited by BCR-ABL down-regulation and is associated with sustained phosphorylation of BCR-ABL and enhanced activation of JAK2–STAT5. Moreover, we identified an AHI-1–BCR-ABL–JAK2 interaction complex and found that modulation of AHI-1 expression regulates phosphorylation of BCR-ABL and JAK2–STAT5 in CML cells. Importantly, this complex mediates TKI response/resistance of CML stem/progenitor cells. These studies implicate AHI-1 as a potential therapeutic target downstream of BCR-ABL in CML

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

Leucine-rich repeat kinase 2 (LRRK2) is a causative gene for Parkinson's disease, but the physiological function and the mechanism(s) by which the cellular activity of LRRK2 is regulated are poorly understood. Here, we identified p21-activated kinase 6 (PAK6) as a novel interactor of the GTPase/ROC domain of LRRK2. p21-activated kinases are serine-threonine kinases that serve as targets for the small GTP binding proteins Cdc42 and Rac1 and have been implicated in different morphogenetic processes through remodeling of the actin cytoskeleton such as synapse formation and neuritogenesis. Using an in vivo neuromorphology assay, we show that PAK6 is a positive regulator of neurite outgrowth and that LRRK2 is required for this function. Analyses of post-mortem brain tissue from idiopathic and LRRK2 G2019S carriers reveal an increase in PAK6 activation state, whereas knock-out LRRK2 mice display reduced PAK6 activation and phosphorylation of PAK6 substrates. Taken together, these results support a critical role of LRRK2 GTPase domain in cytoskeletal dynamics in vivo through the novel interactor PAK6, and provide a valuable platform to unravel the mechanism underlying LRRK2-mediated pathophysiology. We propose p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease (PD). In health, PAK6 regulates neurite complexity in the brain and LRRK2 is required for its function, (a) whereas PAK6 is aberrantly activated in LRRK2-linked PD brain (b) suggesting that LRRK2 toxicity is mediated by PAK6