Derivation of Design Wind and Wave Parameters Considering Climate Change

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Power Generalized KM-Transformation for Non-Monotone Failure Rate Distribution

Lifetime models with a non-monotone hazard rate $\hspace{0.12cm}$ function have a wide range of applications in engineering and lifetime data analysis. There are different bathtub shaped failure rate models that are available in reliability literature. Kavya and Manoharan (2021) introduced a new transformation called KM-transformation which was found to be more useful in reliability and lifetime data analysis. Power generalization technique would be the best approach to deal with a system whose components are connected in series, in which the distribution of the component is KM-transformation of any lifetime model. In this article, we introduce a new lifetime model, Power Generalized KM-Transformation (PGKM) for Non-Monotone Failure Rate Distribution, which shows monotone and non-monotone behavior for the hazard rate function for different choices of values of parameters. We derive the moments, moment generating function, characteristic function, quantiles, entropy etc of the proposed distribution. Distributions of minimum and maximum are obtained. Estimation of parameters of the distribution is performed via maximum likelihood method. A simulation study is performed to validate the maximum likelihood estimator (MLE). Analysis of three sets of real data are given

Evaluation of haematological findings in cases of pancytopenia

Background: Pancytopenia is a clinical condition which poses diagnostic challenge to the haematologist. The aetiology of pancytopenia is varied and depends on many factors. A bone marrow study is highly indicated in cases of pancytopenia and it provides information regarding the underlying disease process. This study was done to learn the causes of pancytopenia and to document how each case was evaluated and followed up.Methods: The present study is a descriptive retrospective one year study on bone marrow samples received in the laboratory. Bone marrow samples included aspirate smears, imprint and trephine and their findings were correlated to arrive at a final diagnosis.Results: Out of the total 28 patients with pancytopenia, 35.71% were from the age group between 61 and 80 years. A male female ratio of 1.5:1 was observed. Most common presenting complaint documented was easy fatiguability. Anisocytosis with macrocytes and ovalocytes were the most common peripheral smear finding. In current study, a cellular marrow was described in 24 (85.71%) cases and hypocellularity in two (7.14%) cases. Final diagnosis was evident in 16 cases, in which the most common cause was acute leukaemia (14.28%) followed by lymphoma infiltration and myelodysplastic syndromes in 3 cases (10.71%).Conclusions: Bone marrow study helps to arrive at a diagnosis of pancytopenia. But proper technique for sampling, good clinical workup and history taking and clinico haematological correlation is mandatory for the proper diagnosis of a pancytopenia case

Non-immune hydrops fetalis: a case of parvovirus B19 infection in pregnancy

Parvovirus B19 infection during pregnancy is mostly asymptomatic, but in approximately 3% of infected women, it can cause hydrops fetalis, severe fetal anemia and even fetal demise. A 23 year old primigravida with 33+5 weeks period of gestation came to our hospital with threatened preterm labour and polyhydramnios. Ultrasound with Doppler showed features of fetal hydrops with fetal anemia. She was tested positive for parvovirus IgM and was planned for intra uterine transfusion. But patient went into preterm labour and delivered a single, stillborn, male of 2.75 kg with no visible gross anamolies. There is currently no approved vaccine or antiviral treatment for parvovirus B19 infection, but counselling of non-immune mothers and active management of confirmed maternal infections with intrauterine transfusion to correct fetal anemia is likely to improve the survival rates with significant reduction in neonatal morbidity and mortality

Method Development and Validation of Simultaneous Estimation of Omeprazole and Cinitapride in Pharmaceutical Dosage forms by Rp-Hplc.

Analytical chemistry is the science that seeks ever improved means of measuring the chemical composition of natural and artificial materials. Chemical composition is the entire picture (composition) of the material at the chemical scale and includes geometric features such as molecular morphologies and distributions of species within a sample as well as single dimensional features such as percent composition and species identity. In the present work a new method development and validation was carried out for the estimation of Omeprazole and Cinitapride by RP-HPLC technique. The wavelength selection was made at 215nm since all the two compounds maximum absorbance at 215 nm. A new method is developed for Simultaneous Estimation of Omeprazole andCinitapride by RP-HPLC method. The sample preparation is simple and the analysis time is short. The analytical procedure is validated as per ICH guidelines and shown to be accurate, precise and specific. A new method is developed for Simultaneous Estimation of Omeprazole andCinitapride by RP-HPLC method. The sample preparation is simple and the analysis time is short. The analytical procedure is validated as per ICH guidelines and shown to be accurate, precise and specific

Survey on Early Detection of Alzheimer's Disease using Different Types of Neural Network Architecture

Alzheimer’s disease is a condition that leads to, progressive neurological brain disorder and destroys cells of the brain thereby causing an individual to lose their ability to continue daily activities and also hampers their mentality. Diagnostic symptoms are experienced by patients usually at later stages after irreversible neural damage occurs. Detection of AD is challenging because sometimes the signs that distinguish AD MRI data, can be found in MRI data of normal healthy brains of older people. Even though this disease is not completely curable, earlier detection can aid in promising treatment and prevent permanent damage to brain tissues. Age and genetics are the greatest risk factors for this disease. This paper presents the latest reports on AD detection based on different types of Neural Network Architectures

Chemotaxonomic studies on Tragia involucrata Linn.

In the present work a common plant in and around trichy, botanically equated as Tragia involucrata Linn belonging to the family Euphorbiaceae, has been studied from chemotaxonomic point of view. The study explained the identification and characterization of the compounds isolated from this plant. The chloroform extract of T. involucrata L was subjected to FT-IR and GC-MS to identify the compounds present in it. The compounds identified were Ar- Tumerone; 9, 10 Anthracenedione 1,8-dihydroxy-3-methyl; Friedelane-3-one. The therapeutic potentials of the active principles identified were already assessed. Ar-Tumerone was already reported from Curcuma longa L and the antibacterial and wound healing activity of this compound was well established. Chemistry of T. involucrata L reported in this present work can contribute significantly in providing chemical evidence in support of its inclusion in the family Euphorbiaceae and assigning the position to the genus Tragia.© 2009 International Formulae Group. All rights reserved.Keywords: Tragia involucrata, Chemotaxonomic studies, Ar-Tumerone

Community solar salt production in Goa, India

Traditional salt farming in Goa, India has been practised for the past 1,500 years by a few communities. Goa’s riverine estuaries, easy access to sea water and favourable climatic conditions makes salt production attractive during summer. Salt produced through this natural evaporation process also played an important role in the economy of Goa even during the Portuguese rule as salt was the chief export commodity. In the past there were 36 villages involved in salt production, which is now reduced to 9. Low income, lack of skilled labour, competition from industrially produced salt, losses incurred on the yearly damage of embankments are the major reasons responsible for the reduction in the number of salt pans. Salt pans (Mithagar or Mithache agor) form a part of the reclaimed waterlogged khazan lands, which are also utilised for aquaculture, pisciculture and agriculture. Salt pans in Goa experience three phases namely, the ceased phase during monsoon period of June to October, preparatory phase from December to January, and salt harvesting phase, from February to June. After the monsoons, the salt pans are prepared manually for salt production. During high tide, an influx of sea water occurs, which enters the reservoir pans through sluice gates. The sea water after 1–2 days on attaining a salinity of approximately 5ºBé, is released into the evaporator pans and kept till it attains a salinity of 23 - 25ºBé. The brine is then released to crystallizer pans, where the salt crystallises out 25 - 27ºBé and is then harvested. Salt pans form a unique ecosystem where succession of different organisms with varying environmental conditions occurs. Organisms ranging from bacteria, archaea to fungi, algae, etc., are known to colonise salt pans and may influence the quality of salt produced. The aim of this review is to describe salt farming in Goa’s history, importance of salt production as a community activity, traditional method of salt production and the biota associated with salt pans