An overlapping local projection stabilization for Galerkin approximations of Stokes and Darcy flow problems

An a priori analysis for a generalized local projection stabilized finite element approximation of the Stokes, and the Darcy flow equations are presented in this paper. A first-order conforming PC1 finite element space is used to approximate both the velocity and pressure. It is shown that the stabilized discrete bilinear form satisfies the inf-sup condition in the generalized local projection norm. Moreover, a priori error estimates are established in a mesh-dependent norm as well as in the L2 -norm for the velocity and pressure. The optimal and quasi-optimal convergence properties are derived for the Stokes and the Darcy flow problems. Finally, the derived estimates are numerically validated with appropriate examples

Generalized local projection stabilized nonconforming finite element methods for Darcy equations

An a priori analysis for a generalized local projection stabilized finite element solution of the Darcy equations is presented in this paper. A first-order nonconforming P nc 1 finite element space is used to approximate the velocity, whereas the pressure is approximated using two different finite elements, namely piecewise constant P0 and piecewise linear nonconforming P nc 1 elements. The considered finite element pairs, P nc 1 /P0 and P nc 1 /P nc 1 , are inconsistent and incompatibility, respectively, for the Darcy problem. The stabilized discrete bilinear form satisfies an inf-sup condition with a generalized local projection norm. Moreover, a priori error estimates are established for both finite element pairs. Finally, the validation of the proposed stabilization scheme is demonstrated with appropriate numerical examples

Radial Basis Neural Network for Availability Analysis

The appliance of radial basis neural network is demostrated in this paper. The method applies failure and repair rate signals to learn the hidden relationship presented into the input pattern. Statistics of availability of several years is considered and collected from the management of concern plant. This data is considered to train and calidate the radial basis neural network (RBNN). Subsequently validated RBNN is used to estimate the availability of concern plant. The main objective of using neural network approach is that it’s not require assumption, nor explicit coding of the problem and also not require the complete knowledge of interdependencies, only requirement is raw data of system functioning

An epidemiological study to assess bone mineral density and its association with contributing factors among premenopausal and postmenopausal women in selected villages of District Shimla, Himachal Pradesh, India

Background: Development of peak bone mass and premenopausal bone loss is determined by the menstrual status of women. Decline in bone mass with age becomes accelerated during menopause. Menopausal bone loss refers to the accelerated bone loss that occurs during the BM) of premenopausal and post-menopausal women, to identify the contributing factors associated with BMD among pre and post-menopausal women, to compare the level of BMD and the contributing factors of pre-menopausal women with post-menopausal women.Methods: It was quantative research approach and epidemiological analytic research design was used. Total enumeration technique was adopted in this study.Results: Analysis of data was done in accordance with the objectives of the study. Findings show that among premenopausal women 45.10% of the women had osteopenia and 8.20% of the women had osteoporosis, among postmenopausal women 50.00% of the women had oestriopenic and 41.2% of the women had osteoporosis. The analysis shows that factors such as BMI, Health status, life style, age, economic status and dietary patter plays important role to accelerate the level of T-score more than -1 in both group either premenopausal women or post-menopausal women. It shows the significance at the level of p<0.001.Conclusions: The study was completed in July 2016, concludes that there are many factors that can lead to have risk of osteoporosis related fracture. As age is increased the risk is also increased to get the fracture. Every woman can go for screening of BMD test to control the risk of fracture

Management of immature teeth by dentin-pulp regeneration : a recent approach

Treatment of the young permanent tooth with a necrotic root canal system and an incompletely developed root is very difficult and challenging. Few acceptable results have been achieved through apexification but use of long-term calcium hydroxide might alter the mechanical properties of dentin. Thus, one alternative approach is to develop and restore a functional pulp-dentin complex. Procedures attempting to preserve the potentially remaining dental pulp stem cells and mesenchymal stem cells of the apical papilla can result in canal revascularization and the completion of root maturation. There are several advantages of promoting apexogenesis in immature teeth with open apices. It encourages a longer and thicker root to develop thus decreasing the propensity of long term root fracture. So, the present article reviews the recent approach of regeneration of pulp-dentin complex in immature permanent teeth. © Medicina Oral S. L

Amelogenesis Imperfecta -Etiology and Prosthodontic Management

Amelogenesis imperfecta represents a variety of structural abnormalities of enamel that result from some malfunction of the enamel organ. The aim of the treatment is to restore esthetics,masticatory function, increase vertical dimension of occlusion and&nbsp; reduce &nbsp;hypersensitivity of teeth. Modern &nbsp;methods and materials have widened the range of available treatment

A clinical study to evaluate the efficacy of Patoladi Kwath (SU. CH.) with or without Rasnadi Pradeh (CH. SU.) in cases of Vatarakta (W.S.R. to Gouty Arthritis)

In Ayurveda, health means the state of Doshasamya, Agnisamya, Dhatusamya and Samanya Malkriya as well as wellness of Atmendriya and Mana1, which according to Acharya Charak is necessary to achieve Dharma, Artha, Kama &amp; Moksha2, the ultimate aim of life. But it has become quite difficult due to the various health obstacles experienced by men during his routine life. The disease Vatarakta is one of them and the number of Vatarakta patient are increasing day by day. The status of Vatarakta is often compared with Gouty Arthritis in the allied sciences. As far as the treatment of Vatarakta/Gouty Arthritis is concerned various research works conducted from time to time, which had shown encouraging result, but still there are many Ayurvedic medicine whose effect has to be established in the management of Vatarakta/Gouty Arthritis based on latest scientific parameters. Acharya Charak has advocated the use of different Ghrit Yog, Tail Yog, Lepa, Pradeha, etc for external application in different types of Vatarakta for relieving pain, swelling, stiffness, burning, itching, etc. So, for this research work we selected Patoladi Kwath from Susrut Chikitsa Sthana 5 and Rasnadi Pradeh from Charak Sutra Sthana 3 to evaluate their efficacy in the management of Vatarakta (w.s.r. to Gouty Arthritis). For this research work 56 diagnosed patient of Vatarakta having age of 21 to 60 years were registered and sequentially randomized into two parallel groups. Leaving 6 dropout (3 from each group), 25 patients of group A were treated with 40 ml Patoladi kwath 2 times a day after meal for 90 days and 25 patients of group B were treated with 40 ml Patoladi kwath 2 times a day after meal with Rasnadi Praddeh for local application over affected joint in the evening for 90 days. The result of the treatment was accessed based on the improvement in terms of symptomatic relief and improvement in terms of Lab investigation i.e, decrease in Serum Uric Acid level and ESR

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets.

BackgroundLiposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease. The Achilles heel of cancer often is their kinases that are excellent therapeutic targets. However, very limited knowledge exists of therapeutic critical kinase targets in liposarcoma that could be potentially used in disease management.MethodsLarge RNAi and small-molecule tyrosine kinase inhibitor screens were performed against the proliferative capacity of liposarcoma cell lines of different subtypes. Each small molecule inhibitor was either FDA approved or in a clinical trial.ResultsScreening assays identified several previously unrecognized targets including PTK2 and KIT in liposarcoma. We also observed that ponatinib, multi-targeted tyrosine kinase inhibitor, was the most effective drug with anti-growth effects against all cell lines. In vitro assays showed that ponatinib inhibited the clonogenic proliferation of liposarcoma, and this anti-growth effect was associated with apoptosis and cell cycle arrest at the G0/G1 phase as well as a decrease in the KIT signaling pathway. In addition, ponatinib inhibited in vivo growth of liposarcoma in a xenograft model.ConclusionsTwo large-scale kinase screenings identified novel liposarcoma targets and a FDA-approved inhibitor, ponatinib with clear anti-liposarcoma activity highlighting its potential therapy for treatment of this deadly tumor