Ginzburg-Landau Approach to Holographic Superconductivity

We construct a family of minimal phenomenological models for holographic superconductors in d=4+1 AdS spacetime and study the effect of scalar and gauge field fluctuations. By making a Ginzburg-Landau interpretation of the dual field theory, we determine through holographic techniques a phenomenological Ginzburg-Landau Lagrangian and the temperature dependence of physical quantities in the superconducting phase. We obtain insight on the behaviour of the Ginzburg-Landau parameter and whether the systems behaves as a Type I or Type II superconductor. Finally, we apply a constant external magnetic field in a perturbative approach following previous work by D'Hoker and Kraus, and obtain droplet solutions which signal the appearance of the Meissner effect.Comment: 41 pages, 31 figures, calculations adde

A simplified design approach to prevent shrinkage cracking in patch repairs

This paper outlines two procedures for determining the interfacial shrinkage stresses in a repair patch. The first is an analytical approach based on the analogy of a bimetallic strip undergoing contraction (shrinkage). The second is a semi-empirical procedure based on strain monitoring of in situ repairs to in-service bridges. The procedures determine conversion factors to relate the specified properties of the repair materials to their in situ properties in a field repair patch. For example, the shrinkage of a repair patch is influenced by the volume–surface effect, site temperature and relative humidity which are not considered in repair material specification. Creep is initiated in situ by differential shrinkage stresses in the repair material and is determined by adopting an effective elastic modulus approach. Both procedures require the basic material properties (elastic modulus, shrinkage, creep) and geometrical details (width, depth) of the repair patch. The analytical approach incorporates the repair material creep coefficient to predict the interfacial tensile stresses. Alternatively, it uses a less rigorous, elastic approach that omits creep. The creep approach provides higher accuracy whereas the elastic approach overestimates stresses since relaxation by creep is neglected. The elastic approach is recommended for design due to its simplicity and the in-built factor of safety provided by the overestimation of tensile stress. The semi-empirical approach uses an expression derived from long-term field data to determine the strain (and consequently stresses) at the interface of the repair patch and the substrate concrete. The procedures predict the maximum interfacial tensile stress during the service life of a repair patch. They can be used to design crack-free repair patches and optimise repair material selection through a better understanding of the interaction between the repair patch and substrate concrete.</p

A second-order lowpass parameter-varying filter based on the interconnection of first-order stages

In recent years, a new class of filters known as parameter- varying filters has been proposed. These filters are characterized by having a transient response of reduced duration while preserving their frequency response properties. The reduction of the transient response of these filters is a consequence of the automatic adjustment of their parameters. These filters may be used in signal processing applications in which the influence of the transient behavior of the filter is seen as an unwanted component of the filter output. In this article, a second-order lowpass parameter-varying filter based on the cascade of first-order parameter-varying stages is presented. The stability properties of the proposed filter, and particularly its bounded-input, bounded-output stability, are verified using a linear time-varying model which accurately represents its behavior when it is subject to the variation of its parameters. The parameters of the filter are varied according to a predefined control strategy. Simulation results confirm the filter capabilities to shorten the duration of its transient behavior when its parameters are varied through the action of a nonlinear control loop

Diseño, Construcción y Evaluación de Celdas de Combustible Microfluídicas para oxidación de glucosa.

Se presentan desarrollos y aportes tecnológicos en el campo de celdas de combustible microfluídicas realizados en CIDETEQ S.C empleando componentes basados en la tecnología de microfabricación. En particular este trabajo está dedicado al diseño, construcción y evaluación de celdas decombustible microfluídicas basadas en la oxidación de glucosa como fuente de energía; usando glucosa como combustible obtenida de diferentes fuentes: sintética (KOH glucosa), cercanas a la real ( solución amortiguadora de fosfatos pH 7+ glucosa) y real (suero o sangre humana)

Glucose microfluidic fuel cell using air as oxidant

A bioanode was constructed using glucose oxidase enzyme (GOx) supported on multiwalled-carbon nanotubes (MWCNTs) in the presence of glutaraldehyde (GA) (GOx/MWCNTs-GA) and evaluated in an air-breathing hybrid glucose microfluidic fuel cell (HG-μFC). The air-breathing HG-μFC operated under physiological conditions (5 mM glucose at pH 7 with an air-exposed cathode) delivers an open circuit value of 0.72 V with 610 μW cm−2 of maximum power density, and shows potential possibilities to develop future implantable applications

Silencing of the Rotavirus NSP4 Protein Decreases the Incidence of Biliary Atresia in Murine Model

Biliary atresia is a common disease in neonates which causes obstructive jaundice and progressive hepatic fibrosis. Our previous studies indicate that rotavirus infection is an initiator in the pathogenesis of experimental biliary atresia (BA) through the induction of increased nuclear factor-kappaB and abnormal activation of the osteopontin inflammation pathway. In the setting of rotavirus infection, rotavirus nonstructural protein 4 (NSP4) serves as an important immunogen, viral protein 7 (VP7) is necessary in rotavirus maturity and viral protein 4 (VP4) is a virulence determiner. The purpose of the current study is to clarify the roles of NSP4, VP7 and VP4 in the pathogenesis of experimental BA. Primary cultured extrahepatic biliary epithelia were infected with Rotavirus (mmu18006). Small interfering RNA targeting NSP4, VP7 or VP4 was transfected before rotavirus infection both in vitro and in vivo. We analyzed the incidence of BA, morphological change, morphogenesis of viral particles and viral mRNA and protein expression. The in vitro experiments showed NSP4 silencing decreased the levels of VP7 and VP4, reduced viral particles and decreased cytopathic effect. NSP4-positive cells had strongly positive expression of integrin subunit α2. Silencing of VP7 or VP4 partially decreased epithelial injury. Animal experiments indicated after NSP4 silencing, mouse pups had lower incidence of BA than after VP7 or VP4 silencing. However, 33.3% of VP4-silenced pups (N = 6) suffered BA and 50% of pups (N = 6) suffered biliary injury after VP7 silencing. Hepatic injury was decreased after NSP4 or VP4 silencing. Neither VP4 nor VP7 were detected in the biliary ducts after NSP4. All together, NSP4 silencing down-regulates VP7 and VP4, resulting in decreased incidence of BA

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study

OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study

Contains fulltext : 218568.pdf (publisher's version ) (Open Access)BACKGROUND: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. METHODS: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 >/= 0.60 during hyperoxemia). RESULTS: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). CONCLUSIONS: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. TRIAL REGISTRATION: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013