Pseudoaneurysm and arterial wall rupture induced by rotational atherectomy in peripheral arterial disease

editorial reviewe

Les défis de l’interdisciplinarité pour la recherche interventionnelle en santé des populations : le cas de la recherche VAPS

International audienceLes enjeux de santé publique auxquels nos systèmes de santé ont à faire face sont multiples et impliquent notamment le développement d’interventions, d’organisations et de politiques innovantes en santé des populations, caractérisées par leur complexité. Appréhender la complexité de ces interventions nécessite une approche interdisciplinaire. Si le besoin d’une telle approche est reconnu, son opérationnalisation reste un défi. Dans ce contexte, cet article vise à présenter les défis de l’interdisciplinarité au regard de ceux rencontrés lors de l’élaboration de la recherche « Évaluation de la viabilité des interventions en santé des populations » (Viability Assessment of population health interventions within Pilot Studies, VAPS). Des questions scientifiques, structurelles et dynamiques sont présentées. La première étape de la recherche implique de poser les bases de la recherche interdisciplinaire avec différents enjeux (problématisation interdisciplinaire, langage commun, compréhension mutuelle des positionnements, motivations, enjeux disciplinaires et contraintes des différents chercheurs). Ensuite, l’interdisciplinarité implique une flexibilité, une communication, et une temporalité, sur l’ensemble du processus de recherche

Elaboração de instrumento para a investigação das falsas memórias.

International audienc

Les défis de l’interdisciplinarité pour la recherche interventionnelle en santé des populations : le cas de la recherche VAPS

International audienceLes enjeux de santé publique auxquels nos systèmes de santé ont à faire face sont multiples et impliquent notamment le développement d’interventions, d’organisations et de politiques innovantes en santé des populations, caractérisées par leur complexité. Appréhender la complexité de ces interventions nécessite une approche interdisciplinaire. Si le besoin d’une telle approche est reconnu, son opérationnalisation reste un défi. Dans ce contexte, cet article vise à présenter les défis de l’interdisciplinarité au regard de ceux rencontrés lors de l’élaboration de la recherche « Évaluation de la viabilité des interventions en santé des populations » (Viability Assessment of population health interventions within Pilot Studies, VAPS). Des questions scientifiques, structurelles et dynamiques sont présentées. La première étape de la recherche implique de poser les bases de la recherche interdisciplinaire avec différents enjeux (problématisation interdisciplinaire, langage commun, compréhension mutuelle des positionnements, motivations, enjeux disciplinaires et contraintes des différents chercheurs). Ensuite, l’interdisciplinarité implique une flexibilité, une communication, et une temporalité, sur l’ensemble du processus de recherche

Accompagnement à la parentalité en Protection maternelle et infantile : co-construction de la logique d’intervention PERL

Introduction : En région Grand Est (France), une intervention de prévention primaire en périnatalité a montré des résultats encourageants sur le développement de l’enfant. Afin de rendre cette intervention transférable et pérenne hors d’un contexte de recherche, elle a été adaptée dans une politique de santé familiale universelle et évaluée par la recherche « Petite enfance, recherche-action en Lorraine » (PERL).Méthode : L’objectif de l’article est d’exposer la logique d’intervention de PERL, explicitée par l’évaluation des processus et mécanismes (2018-2019). Ancrée dans une démarche de co-construction, la méthode s’est structurée autour de 18 entretiens suivis d’un processus de concertation auprès des acteurs–chercheurs–décideurs impliqués.Résultats : Porté par les services de protections maternelle et infantile (PMI), PERL s’articule autour de visites au domicile de puéricultrices, d’analyses des pratiques et de supervisions. À l’inverse d’une tendance à la normalisation, l’approche reconnaît le parent comme expert de son enfant et propose un accompagnement le soutenant dans son rôle. L’importance des supervisions, pour soutenir les puéricultrices confrontées à des situations complexes, constitue une des pierres angulaires du dispositif.Discussion : PERL est un programme structuré et non standardisé d’accompagnement à la parentalité, impliquant des concepts forts de « promotion de la santé ». Cette évaluation met en avant l’importance de bénéficier d’une vision partagée de la logique d’une intervention ainsi que les défis sous-jacents. Dans la perspective du déploiement et du transfert de PERL il sera nécessaire d’adapter le dispositif aux contextes et aux territoires. Pour cela, un guide de mise en œuvre a été réalisé.Introduction: In the Greater Eastern region of France, a primary prevention intervention in perinatal care has shown promising results on child development. In order to make this intervention transferable and sustainable outside a research context, it was adapted into a universal family health program. The PERL (Petite Enfance Recherche-action en Lorraine: early childhood research-action in Lorraine) research-action aimed to evaluate the effects of this new intervention. Method: The objective of the article was to present the intervention logic of the PERL program, based on the evaluation of processes and mechanisms (2018-2019). The method was based on 18 semi-structured interviews with actors involved in the construction and implementation of PERL, and a consultation process. Results: Supported by the Maternal and Child Protection services (PMI), PERL is a program based on home visits by nurses, analysis of practices and supervision. In contrast to a standardized or an injunctive perspective, the approach recognizes and supports the parent as an expert of his or her own child. The importance of supervision in facilitating the adoption of an unconditional benevolent posture and the professional development of nurses confronted with complex situations is one of the cornerstones of the system. Conclusions: PERL is a structured and non-standardized parenting support program, based on strong health promotion concepts. This evaluation underlines the importance and challenges of having a shared vision of the intervention logic. In the perspective of the deployment and transfer of PERL, it will be necessary to adapt the system to the contexts and territories. In this perspective, an implementation guide has been produced

Post-Thrombolysis Recanalization in Stroke Referrals for Thrombectomy

International audienceBackground and Purpose—Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) is still unclear; (2) thrombolysis may be harmful in patients unlikely to recanalize; and, conversely, (3) transfer for MT may be unnecessary in patients highly likely to recanalize. Here, we determined the incidence and predictors of post-thrombolysis ER in patients referred for MT and derive ER prediction scores for trial design. Methods—Registries from 4 MT-capable centers gathering patients referred for MT and thrombolyzed either on site (mothership) or in a non MT-capable center (drip-and-ship) after magnetic resonance– or computed tomography–based imaging between 2015 and 2017. ER was identified on either first angiographic run or noninvasive imaging. In the magnetic resonance imaging subsample, thrombus length was determined on T2*-based susceptibility vessel sign. Independent predictors of no- ER were identified using multivariable logistic regression models, and scores were developed according to the magnitude of regression coefficients. Similar registries from 4 additional MT-capable centers were used as validation cohort. Results—In the derivation cohort (N=633), ER incidence was ≈20%. In patients with susceptibility vessel sign (n=498), no-ER was independently predicted by long thrombus, proximal occlusion, and mothership paradigm. A 6-point score derived from these variables showed strong discriminative power for no-ER (C statistic, 0.854) and was replicated in the validation cohort (n=353; C statistic, 0.888). A second score derived from the whole sample (including negative T2* or computed tomography–based imaging) also showed good discriminative power and was similarly validated. Highest grades on both scores predicted no-ER with >90% specificity, whereas low grades did not reliably predict ER. Conclusions—The substantial ER rate underlines the benefits derived from thrombolysis in bridging populations. Both prediction scores afforded high specificity for no-ER, but not for ER, which has implications for trial design

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Background: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods: For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings: Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14–2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low. Interpretation: Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons