Women\u27s Indirect Intra-Gender Aggression: A Study of Workplace Relationships

In the 21st century, there are more women in the workforce than ever before. These women work in places and positions across the professional spectrum, and to their positions they bring higher degrees and they compete for higher-paying positions that bring added responsibility. Research has demonstrated that these women and many women have been taught that relationships are important-and that relationships are maintained by avoiding confrontation. Women in the workforce, then, strive to be friends and coworkers at once, and when conflict, disagreement, and/or hurt feelings arise, they often resort to indirect and covertly aggressive behaviors such as gossip, rumors, and exclusion of select others from group activities and conversations. Based on an extensive review of relevant literature and using interviews conducted with seven working women, this research illuminates working women\u27s relationship to the Power Dead-Even Rule. Finally, the research suggests a path toward avoiding indirectly aggressive behaviors and building a healthy, productive work environment

A review of congenital heart block

Congenital heart block is a rare disorder. It has an incidence of about 1 in 22,000 live births. It may be associated with high mortality and morbidity. This should generate a high index of suspicion for early diagnosis and aggressive therapy when appropriate. The congenital heart block associated with neonatal lupus is considered a form of passively acquired autoimmune disease in which maternal autoantibodies to the intracellular ribonucleoproteins Ro (SS-A) and La (SS-B), cross the placenta and injure the previously normal fetal heart. Women with serum titers of anti-Ro antibody carry a 3% risk of having a child with neonatal lupus syndrome. Recurrence rates are about 18%. We believe that serial echocardiograms should be acquired so that early diagnosis is made and aggressive therapy administered, if signs of conduction system disease such as PR interval prolongation by Doppler are found, so as to optimize the outcome. Establishment of guidelines for therapy have been set empirically, should signs of congenital heart block develop. Those patients whose congenital heart block is associated with structural heart disease have a higher morbidity and mortality, which is determined more by the underlying structural congenital heart disease than it is by the need for a pacemaker per se.peer-reviewe

Use of Most Bothersome Symptom as a Coprimary Endpoint in Migraine Clinical Trials: A Post-Hoc Analysis of the Pivotal ZOTRIP Randomized, Controlled Trial.

ObjectiveTo better understand the utility of using pain freedom and most bothersome headache-associated symptom (MBS) freedom as co-primary endpoints in clinical trials of acute migraine interventions.BackgroundAdhesive dermally applied microarray (ADAM) is an investigational system for intracutaneous drug administration. The recently completed pivotal Phase 2b/3 study (ZOTRIP), evaluating ADAM zolmitriptan for the treatment of acute moderate to severe migraine, was one of the first large studies to incorporate MBS freedom and pain freedom as co-primary endpoints per recently issued guidance by the US Food and Drug Administration. In this trial, the proportion of patients treated with ADAM zolmitriptan 3.8 mg, who were pain-free and MBS-free at 2 hours post-dose, was significantly higher than for placebo.MethodsWe undertook a post-hoc analysis of data from the ZOTRIP trial to examine how the outcomes from this trial compare to what might have been achieved using the conventional co-primary endpoints of pain relief, nausea, photophobia, and phonophobia.ResultsOf the 159 patients treated with ADAM zolmitriptan 3.8 mg or placebo, prospectively designated MBS were photophobia (n = 79), phonophobia (n = 43), and nausea (n = 37). Two-hour pain free rates in those with photophobia as the MBS were 36% for ADAM zolmitriptan 3.8 mg and 14% for placebo (P = .02). Corresponding rates for those with phonophobia as the MBS were 14% and 41% (P = .05). For those whose MBS was nausea, corresponding values were 56% and 16%, respectively (P = .01). Two-hour freedom from the MBS for active drug vs placebo were 67% vs 35% (P < .01) for photophobia, 55% vs 43% (P = .45) for phonophobia, and 89% vs 58% for nausea (P = .04). MBS freedom but not pain freedom was achieved in 28%. Only 1 patient (1%) achieved pain freedom, but not MBS freedom. The proportion with both pain and MBS freedom was highest (56%) among those whose MBS was nausea.ConclusionIn this study, the use of MBS was feasible and seemed to compare favorably to the previously required 4 co-primary endpoints

Disaster Preparedness Information Needs of Individuals Attending an Adult Literacy Center : An Exploratory Study

Being prepared with accurate, credible, and timely information during a disaster can help individuals make informed decisions about taking appropriate actions. Unfortunately, many people have difficulty understanding health and risk-related resources. This exploratory, mixed methods study assessed disaster information-seeking behaviors and comprehension of public health disaster preparedness resources by individuals at an adult literacy center. A convenience pilot sample of 20 adult learners (mean age: 53.1) was recruited. Health literacy was assessed using Newest Vital Sign (NVS) and modified Cloze (multiple choice) tests on biological terrorism and avian influenza information. In-person interviews were conducted to determine participants’ knowledge, perceptions, and information needs about disasters. Thematic analysis of interviews was conducted using NVivo7. Mean NVS was 3.11/6.00 implying limited health literacy. Mean Cloze scores revealed marginal disaster comprehension (avian flu: .46/1.00; biological terrorism: .48/1.00). Over half of participants with inadequate Cloze comprehension self-rated their understanding as “good.” Key themes emerging from interviews were: multiple perceptions about disasters, limited access to preparedness resources, need for visuals and plain language information, and importance of knowing where to go during a disaster. Study findings advocate for multimedia, plain language, and visual communication to influence adult learners’ literacy practices and self-efficacy in interpreting instructions and acting appropriately in preparing for and responding to disasters