CHANG-ES IV: Radio continuum emission of 35 edge-on galaxies observed with the Karl G. Jansky Very Large Array in D-configuration, Data Release 1

We present the first part of the observations made for the Continuum Halos in Nearby Galaxies, an EVLA Survey (CHANG-ES) project. The aim of the CHANG-ES project is to study and characterize the nature of radio halos, their prevalence as well as their magnetic fields, and the cosmic rays illuminating these fields. This paper reports observations with the compact D configuration of the Karl G. Jansky Very Large Array (VLA) for the sample of 35 nearby edge-on galaxies of CHANG-ES. With the new wide bandwidth capabilities of the VLA, an unprecedented sensitivity was achieved for all polarization products. The beam resolution is an average of 9.6" and 36" with noise levels reaching approximately 6 and 30 microJy per beam for C- and L-bands, respectively (robust weighting). We present intensity maps in these two frequency bands (C and L), with different weightings, as well as spectral index maps, polarization maps, and new measurements of star formation rates (SFRs). The data products described herein are available to the public in the CHANG-ES data release available at www.queensu.ca/changes. We also present evidence of a trend among galaxies with larger halos having higher SFR surface density, and we show, for the first time, a radio continuum image of the median galaxy, taking advantage of the collective signal-to-noise ratio of 30 of our galaxies. This image shows clearly that a typical spiral galaxy is surrounded by a halo of magnetic fields and cosmic rays.Comment: 70 pages, of which 35 pages present the data of each galax

The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease

Self-consciousness concept and assessment in self-report measures

This study examines how self-consciousness is defined and assessed using self-report questionnaires (Self-Consciousness Scale, Self-Reflection and Insight Scale, Self-Absorption Scale, Rumination-Reflection Questionnaire, and Philadelphia Mindfulness Scale). Authors of self-report measures suggest that self-consciousness can be distinguished by its private/public aspects, its adaptive/maladaptive applied characteristics, and present/past experiences. We examined these claims in a study using 602 young adults to whom the aforementioned scales were administered. Data were analysed as follows: (1) correlation analysis to find simple associations between the measures; (2) factorial analysis using Oblimin rotation of total scores provided from the scales; and (3) factorial analysis considering the 102 items of the scales all together. It aimed to clarify relational patterns found in the correlations between self-consciousness scales, and to identify possible latent constructs behind these scales. Results support the adaptive/maladaptive aspects of self-consciousness, as well as distinguish to some extent public aspects from private ones. However, some scales that claimed to be theoretically derived from the concept of Private Self-Consciousness correlated with some of its public self-aspects. Overall, our findings suggest that while self-reflection measures tend to tap into past experiences and judged concepts that were already processed by the participants' inner speech and thoughts, the Awareness measure derived from Mindfulness Scale seems to be related to a construct associated with present experiences in which one is aware of without any further judgment or logical/rational symbolization. This sub-scale seems to emphasize the role that present experiences have in self-consciousness, and it is argued that such a concept refers to what has been studied by phenomenology and psychology over more than one hundred years: the concept of pre-reflective self-conscious

Extended-Family Talk about Sex and Teen Sexual Behavior

Research shows that family sexuality communication is protective for teens’ risky sexual behavior, but most studies on this topic focus exclusively on the parent–teen dyad. The few studies that assessed extended family sexuality communication use a single item to measure this communication and showed mixed results as to whether it is associated with sexual risk behaviors for teens. The current study included cross-sectional survey data from 952 teens in the 11th and 12th grades. Structural equation modeling (SEM) was used to assess associations between teens’ sexual risk behaviors and communication with extended family about protection methods, risks of sex and relational approaches to sex. Results showed that, for sexually active teens, talk about protection methods was associated with fewer sexual partners and talk about risks of sex was associated with more sexual partners, even after accounting for talk with parents about sex and controlling for teen gender, racial/ethnic background and mothers’ education. Results suggest that extended family talk with teens about sex might protect them from risky sexual behavior, over and above the effects of teen–parent communication. However, the direction of the effect depends on the content of the conversations. Talk about protection might support teens’ sexual health, while talk about risks of sex with teens who have already had sex, might not be effective. These findings suggest the need to explore whether and how extended family could be included in health prevention and intervention programs, which currently focus on parents

Father-Teen Talks about Sex and Teens’ Sexual Health: The Role of Direct and Indirect Communication

Family talks about sex can protect against teens’ risky sexual behavior, but most research has focused on the role of mothers. The current study included cross-sectional survey data from 728 adolescents in the 11th and 12th grades (Mage = 17.00, SD = 0.90) in the United States. Structural equation modeling (SEM) was used to assess associations between teens’ direct and indirect talk, defined as less straightforward ways to communicate one’s sexual values, with fathers about sex, and teens’ sexual behaviors. There were no significant direct associations between father-teen talk about sex and teens’ sexual behavior. However, teen gender moderated associations between indirect father-teen communication and teens’ sexual behavior. The results suggest the need to assess indirect talk about sex in studies of family sexuality communication and to further investigate the role of teens’ identities in determining the influence of father-teen talk about sex on teens’ sexual behavior

A lógica da dialogicidade narrativa no repertório de posições pessoais

O objetivo deste estudo foi analisar as relações lógicas que fundamentam a abordagem dialógica do self e sua contraparte instrumental, o Repertório de Posições Pessoais (RPP). A análise partiu da evidência fornecida pela aplicação do RPP a 17 participantes com idade entre 19 e 34 anos (11 mulheres). Os resultados sugeriram dois contextos para o fenômeno da dialogicidade: a possibilidade de uma pessoa perceber-se como uma multiplicidade de características, e de construir narrativas sobre si a partir de diferentes pontos de vista. Esses resultados indicaram que o RPP é capaz de demonstrar a estrutura espacial da dialogicidade, mas não a dialogicidade em ação, que se revela um resultado da natureza narrativa do self. Para concluir, são discutidas limitações e possibilidades do RPP

Extended-Family Talk about Sex and Teen Sexual Behavior

Research shows that family communication about sexuality can protect against teens’ risky sexual behavior. However, few studies assess talk with extended family about sex or how this communication relates to teens’ sexual behavior. The current study includes cross-sectional survey data from 952 adolescents. Structural equation modeling (SEM) was used to assess associations between teens’ sexual risk behaviors and communication with extended family about protection methods, risks of sex and relational approaches to sex, defined as talk about sex within a close relationship. For sexually active teens, talk about protection methods was associated with fewer sexual partners and talk about risks of sex was associated with more sexual partners regardless of teen gender and the generation of extended family with whom teens talk. Results suggest that extended-family talk about sex may influence teens’ sexual behavior independent of effects of teen⁻parent communication. However, the direction of the effect depends on the content of the conversations. These findings suggest the need to explore whether and how extended family could be included in health prevention and intervention programs, because programs which include family largely focus on parents