Discovery of meteorites on a blue-ice field near the Frontier Mountains, North Victoria Land, Antarctica

A high concentration of meteorites were discovered on a blue ice field northeast of the Frontier Mountains. As a result of a systematic search, a total of 42 meteorites were recovered. The current glacial situation has evolved through various stages, which are discussed in relationship to the concentration of meteorites. Ice flow patterns are summarized. The chemical composition and terrestrial ages of the meteorites are discussed

At-risk serum cholesterol profile at both ends of the nutrition spectrum in West African adults? The Benin study

Low HDL-cholesterol (HDL-C), using as cut-offs 1.03 mmol/L in men and 1.29 mmol/L in women, was observed in more than 25% apparently healthy adults (n = 541) in a cross-sectional study on nutrition transition and cardiometabolic risk factors (CMRF) in Benin, West Africa. Both overweight/obesity (35.3%) and underweight (11.3%) were present, displaying the double burden of malnutrition. We examined in more depth the association of low HDL-C with nutrition and with other CMRF. Metabolic syndrome components were assessed, plus the ratio of total cholesterol (TC)/HDL-C and serum homocysteine. Insulin resistance was based on Homeostasis Model Assessment. We also measured BMI and body composition by bio-impedance. Dietary quality was appraised with two non-consecutive 24 h recalls. Low HDL-C was associated with much higher TC/HDL-C and more abdominal obesity in men and women and with more insulin resistance in women. The rate of low HDL-C was highest (41.9%) among the overweight/obese subjects (BMI ≥ 25), but it also reached 31.1% among the underweight (BMI < 18.5), compared with 17.3% among normal-weight subjects (p < 0.001). Lower dietary micronutrient adequacy, in particular, in vitamins A, B3, B12, zinc and calcium, was associated with low HDL-C when controlling for several confounders. This suggests that at-risk lipoprotein cholesterol may be associated with either underweight or overweight/obesity and with poor micronutrient intake

Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib.

BackgroundEarly detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), a trial of torcetrapib (a cholesterol ester transfer protein inhibitor), that involved 15 067 participants at high cardiovascular risk. ILLUMINATE was terminated at a median of 550 days because of significant absolute increases of 1.2% in cardiovascular events and 0.4% in mortality with torcetrapib. The aims of our analysis were to determine whether a proteomic analysis might reveal biological mechanisms responsible for these harmful effects and whether harmful effects of torcetrapib could have been detected early in the ILLUMINATE trial with proteomics.MethodsA nested case-control analysis of paired plasma samples at baseline and at 3 months was performed in 249 participants assigned to torcetrapib plus atorvastatin and 223 participants assigned to atorvastatin only. Within each treatment arm, cases with events were matched to controls 1:1. Main outcomes were a survey of 1129 proteins for discovery of biological pathways altered by torcetrapib and a 9-protein risk score validated to predict myocardial infarction, stroke, heart failure, or death.ResultsPlasma concentrations of 200 proteins changed significantly with torcetrapib. Their pathway analysis revealed unexpected and widespread changes in immune and inflammatory functions, as well as changes in endocrine systems, including in aldosterone function and glycemic control. At baseline, 9-protein risk scores were similar in the 2 treatment arms and higher in participants with subsequent events. At 3 months, the absolute 9-protein derived risk increased in the torcetrapib plus atorvastatin arm compared with the atorvastatin-only arm by 1.08% (P=0.0004). Thirty-seven proteins changed in the direction of increased risk of 49 proteins previously associated with cardiovascular and mortality risk.ConclusionsHeretofore unknown effects of torcetrapib were revealed in immune and inflammatory functions. A protein-based risk score predicted harm from torcetrapib within just 3 months. A protein-based risk assessment embedded within a large proteomic survey may prove to be useful in the evaluation of therapies to prevent harm to patients.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00134264

Pressure induced structural and dynamical changes in liquid Si. An ab-initio study

The static and dynamic properties of liquid Si at high-pressure have been studied using the orbital free ab-initio molecular dynamics method. Four thermodynamic states at pressures 4, 8, 14 and 23 GPa are considered. The calculated static structure shows qualitative agreement with the available experimental data. We analize the remarkable structural changes occurring between 8 and 14 GPa along with its effect on several dynamic properties.Comment: 10 pages, 11 figures. Accepted for publication in Journal of Physics: Condensed Matte

Using primary sources to produce a microhistory of translation and translators: theoretical and methodological concerns

In descriptive studies, where the source and target texts are the main primary sources (‘primary text products’), ‘extra-textual’ sources are looked at with ‘circumspection’. However, in historical research methodologies they are central. This article examines the use and value of archives, manuscripts and, especially, translator papers, post-hoc accounts and interviews in producing a history of translation and translators. Rather than informing a ‘traditional’ Rankean history of facts and major personalities, the article underlines the potential value of such material in creating a ‘microhistory’, reclaiming the details of the everyday lives and working processes of sometimes little-known or forgotten translators and contextualising them to construct a social and cultural history of translation and translators. Sometimes these sources are housed in collections where translation may not be very visible, which creates problems of location. Examples are given from the autobiography of A. Birse and research on the working papers of Sam Hileman, Andrew Hurley, Bernard Miall and Margaret Sayers Peden

The Reform of Employee Compensation in China’s Industrial Enterprises

Although employee compensation reform in Chinese industrial sector has been discussed in the literature, the real changes in compensation system and pay practices have received insufficient attention and warrant further examination. This paper briefly reviews the pre- and post-reform compensation system, and reports the results of a survey of pay practices in the four major types of industrial enterprises in China. The research findings indicate that the type of enterprise ownership has little influence on general compensation practices, adoption of profit-sharing plans, and subsidy and allowance packages. In general, pay is linked more to individual performance and has become an important incentive to Chinese employees. However, differences are found across the enterprise types with regard to performance-related pay. Current pay practices are positively correlated to overall effectiveness of the enterprise

The Rossiter–McLaughlin effect revolutions: an ultra-short period planet and a warm mini-Neptune on perpendicular orbits

Comparisons of the alignment of exoplanets with a common host star can be used to distinguish among concurrent evolution scenarios. However, multi-planet systems usually host mini-Neptunes and super-Earths, whose size make orbital architecture measurements challenging. We introduce the Rossiter-McLaughlin effect Revolutions technique, which can access spin-orbit angles of small planets by exploiting the full information contained in spectral transit time series. We validated the technique on published HARPS-N data of the mini-Neptune HD3167c, refining its high sky-projected spin-orbit angle (-108.9+5.4-5.5 deg), and we applied it to new ESPRESSO observations of the super-Earth HD3167b, revealing an aligned orbit (-6.6+6.6-7.9 deg). Surprisingly different variations in the contrast of the stellar lines occulted by the planets can be reconciled with a latitudinal dependence of the stellar line shape. In this scenario, a joint fit to both datasets constrains the inclination of the star (111.6+3.1-3.3 deg) and the 3D spin-orbit angles of HD3167b (29.5+7.2-9.4 deg) and HD3167c (107.7+5.1-4.9 deg). The projected spin-orbit angles do not depend on the model for the line contrast variations, and so, with a mutual inclination of 102.3+7.4-8.0 deg, we conclude that the two planets are on perpendicular orbits. This could be explained by HD3167b being strongly coupled to the star and retaining its primordial alignment, whereas HD3167c would have been brought to a nearly polar orbit via secular gravitational interactions with an outer companion. Follow-up observations and dynamical evolution simulations are required to search for this companion and explore this scenario. HD3167b is the smallest exoplanet with a confirmed spectroscopic Rossiter-McLaughlin signal. Our new technique opens the way to determining the orbital architectures of the super-Earth and Earth-sized planet populations