3-Benzyl-1-butyl­imidazo[1,2-a]benzo­thieno[3,2-d]pyrimidine-2,5(1H,3H)-dione

In the crystal structure of the title compound, C23H21N3O2S, all ring atoms of the imidazo[1,2-a]benzothieno[3,2-d]pyrimidine system are essentially coplanar and the phenyl ring is twisted with respect to it [dihedral angle = 72.60 (9)°]. The crystal packing is mainly governed by C—H⋯π hydrogen bonds and inter­molecular π–π inter­actions, with inter­planar distances of 3.54 (1) and 3.56 (1) Å, and with distances between adjacent ring centroids of 3.72 (1) and 3.80 (1) Å. The three terminal C atoms of the butyl group are disordered over two positions; the site occupancy factors are ca 0.6 and 0.4

Cloning and characterization of an S-RNase gene in Camellia sinensis

AbstractSelf-incompatibility (SI) prevents inbreeding depression in angiosperms. Camellia sinensis is an important cash crop, but breeding improvements and genetic studies of the plant are hindered by SI. However, the SI mechanism in C. sinensis remains unclear. In this study, a putative S-RNase gene (KU852488) was cloned from C. sinensis. The full-length cDNA of CsS-RNase is 1121bp, which encodes 238 amino acids. It shares the closest relationship with an S-RNase gene (ADA67883.1), which was cloned from a self-incompatibility Citrus reticulata cultivar ‘Wuzishatangju’. The expression level of CsS-RNase in the styles were 3–259 (‘Fuding Dabaicha’) and 5.6–119 (‘Zhongcha108’) times higher than the other tissues, for example petals, pollen grains, filaments and buds. And its expression rose in self-pollinated styles with 24h earlier than cross-pollinated styles. The genotypes of CsS-RNase in 10 cultivars and one breeding line of C. sinensis were analyzed. Totally, 11 polymorphic amino acid residues were identified. A single nucleotide polymorphism (SNP) marker of CsS-RNase was developed. Finally, the CsS-RNase was mapped onto a reference genetic linkage map of tea plant

Synthesis of hollow poly(aniline-co-pyrrole)–Fe3O4 composite nanospheres and their microwave absorption behavior

Hollow poly(aniline-co-pyrrole)-Fe3O4 (HPAP-Fe3O4) nanospheres with significant electromagnetic properties were successfully prepared via the oxidative polymerization of a mixture of aniline and pyrrole in the presence of a magnetic fluid, using a non-ionic surfactant as a template. The products were characterized by field emission scanning electron microscopy, transmission electron microscopy. Fourier transform infrared spectroscopy, X-ray powder diffraction, thermogravimetric analysis and Xray photoelectron spectroscopy. The electromagnetic (EM) and microwave absorbing properties of the nanocomposites were also investigated. The HPAP-Fe3O4 nanospheres exhibit superparamagnetic properties, and the conductivity increases with Fe3O4 content. The reflection loss evaluation based on the absorbing wall theory at 2 mm thickness shows that the reflection loss is reinforced in the frequency range of 0.5-10 GHz by the presence of Fe3O4 nanoparticles, and the frequency of minimum reflection loss shifts to a higher value with increasing Fe3O4 content. HPAP-Fe-06 exhibits the best microwave absorbing property between 0.5 and 10 GHz.ArticleSYNTHETIC METALS. 162(3-4):337-343 (2012)journal articl

Scaling and memory in the non-poisson process of limit order cancelation

The order submission and cancelation processes are two crucial aspects in the price formation of stocks traded in order-driven markets. We investigate the dynamics of order cancelation by studying the statistical properties of inter-cancelation durations defined as the waiting times between consecutive order cancelations of 22 liquid stocks traded on the Shenzhen Stock Exchange of China in year 2003. Three types of cancelations are considered including cancelation of any limit orders, of buy limit orders and of sell limit orders. We find that the distributions of the inter-cancelation durations of individual stocks can be well modeled by Weibulls for each type of cancelation and the distributions of rescaled durations of each type of cancelations exhibit a scaling behavior for different stocks. Complex intraday patterns are also unveiled in the inter-cancelation durations. The detrended fluctuation analysis (DFA) and the multifractal DFA show that the inter-cancelation durations possess long-term memory and multifractal nature, which are not influenced by the intraday patterns. No clear crossover phenomenon is observed in the detrended fluctuation functions with respect to the time scale. These findings indicate that the cancelation of limit orders is a non-Poisson process, which has potential worth in the construction of order-driven market models.Comment: 13 Latex pages, 6 figure

Risk factors for lateral pelvic lymph node metastasis in patients with lower rectal cancer: a systematic review and meta-analysis

Background and objectiveLateral pelvic lymph node (LPLN) metastasis is one of the prominent reasons for local recurrence (LR) in patients with rectal cancer (RC). The evaluation criteria of lateral lymph node dissection (LLND) for patients in eastern (mainly in Japan) and western countries have been controversial. The aim of this study was to analyse the risk factors for LPLN metastasis in order to guide surgical methods.MethodsWe searched relevant databases (Embase (Ovid), Medline (Ovid), PubMed, Cochrane Library, and Web of Science) for articles published between 1 January 2000 and 05 October 2022 to evaluate the risk factors for LPLN metastasis in patients with RC in this meta-analysis.ResultsA total of 24 articles with 5843 patients were included in this study. The overall results showed that female sex, age <60 years, pretherapeutic CEA level >5 ng/ml, clinical T4 stage (cT4), clinical M1 stage (cM1), distance of the tumour from the anal verge (AV) <50 mm, tumour centre located below the peritoneal reflection (Rb), short axis (SA) of LPLN ≥8 mm before nCRT, short axis (SA) of LPLN ≥5 mm after nCRT, border irregularity of LPLN, tumour size ≥50 mm, pathological T3-4 stage (pT3-4), pathological N2 stage (pN2), mesorectal lymph node metastasis (MLNM), lymphatic invasion (LI), venous invasion (VI), CRM (+) and poor differentiation were significant risk factors for LPLN metastasis (P <0.05).ConclusionThis study summarized almost all potential risk factors of LPLN metastasis and expected to provide effective treatment strategies for patients with LRC. According to the risk factors of lateral lymph node metastasis, we can adopt different comprehensive treatment strategies. High-risk patients can perform lateral lymph node dissection to effectively reduce local recurrence; In low-risk patients, we can avoid overtreatment, reduce complications and trauma caused by lateral lymph node dissection, and maximize patient survival and quality of life

Breakdown for the Camassa-Holm Equation Using Decay Criteria and Persistence in Weighted Spaces

We exhibit a sufficient condition in terms of decay at infinity of the initial data for the finite time blowup of strong solutions to the Camassa--Holm equation: a wave breaking will occur as soon as the initial data decay faster at infinity than the solitons. In the case of data decaying slower than solitons we provide persistence results for the solution in weighted $L^p$-spaces, for a large class of moderate weights. Explicit asymptotic profiles illustrate the optimality of these results

Pressure-induced superconductivity in Eu0.5_{0.5}Ca0.5_{0.5}Fe2_2As2_2 : FeAs-based superconductivity hidden by antiferromagnetism of Eu sublattice

To clarify superconductivity in EuFe2As2 hidden by antiferromagnetism of Eu2+, we investigated a Ca-substituted sample, Eu0.5Ca0.5Fe2As2, under high pressure. For ambient pressure, the sample exhibits a spin-density-wave (SDW) transition at TSDW = 191 K and antiferromagnetic order at TN = 4 K, but no evidence of superconductivity down to 2 K. The Ca-substitution certainly weakens the antiferromagnetism. With increasing pressure, TSDW shifts to lower temperature and becomes more unclear. Above 1.27 GPa, pressure-induced superconductivity with zero resistivity is observed at around Tc = 20 K. At 2.14 GPa, Tc reaches a maximum value of 24 K and the superconducting transition becomes the sharpest. These features of emergence of the superconductivity are qualitatively similar to those observed in AFe2As2 (A = Ba, Ca).Comment: 4 pages, 4 figure

GLMMLasso: An Algorithm for High-Dimensional Generalized Linear Mixed Models Using L1-Penalization

We propose an L1-penalized algorithm for fitting high-dimensional generalized linear mixed models. Generalized linear mixed models (GLMMs) can be viewed as an extension of generalized linear models for clustered observations. This Lasso-type approach for GLMMs should be mainly used as variable screening method to reduce the number of variables below the sample size. We then suggest a refitting by maximum likelihood based on the selected variables only. This is an effective correction to overcome problems stemming from the variable screening procedure which are more severe with GLMMs. We illustrate the performance of our algorithm on simulated as well as on real data examples. Supplemental materials are available online and the algorithm is implemented in the R package glmmixedlasso