492 research outputs found
A Complete Model of Low-Scale Gauge Mediation
Recent signs of a Standard Model-like Higgs at 125 GeV point towards large
A-terms in the MSSM. This presents special challenges for gauge mediation,
which by itself predicts vanishing A-terms at the messenger scale. In this
paper, we review the general problems that arise when extending gauge mediation
to achieve large A-terms, and the mechanisms that exist to overcome them. Using
these mechanisms, we construct weakly-coupled models of low-scale gauge
mediation with extended Higgs-messenger couplings that generate large A-terms
at the messenger scale and viable mu/B_mu-terms. Our models are simple,
economical, and complete realizations of supersymmetry at the weak scale.Comment: 33 pages; v2: refs added, minor change
Top Partner Discovery in the channel at the LHC
In this paper we study the discovery potential of the LHC run II for heavy
vector-like top quarks in the decay channel to a top and a boson. Despite
the usually smaller branching ratio compared to charged-current decays, this
channel is rather clean and allows for a complete mass reconstruction of the
heavy top. The latter is achieved in the leptonic decay channel of the
boson and in the fully hadronic top channel using boosted jet and jet
substructure techniques. To be as model-independent as possible, a simplified
model approach with only two free parameters has been applied. The results are
presented in terms of parameter space regions for evidence or
discovery for such new states in that channel.Comment: 24 pages, 8 figures, version 2 updated to JHEP 01 (2015) 08
PAMELA results on the cosmic-ray antiproton flux from 60 MeV to 180 GeV in kinetic energy
The satellite-borne experiment PAMELA has been used to make a new measurement
of the cosmic-ray antiproton flux and the antiproton-to-proton flux ratio which
extends previously published measurements down to 60 MeV and up to 180 GeV in
kinetic energy. During 850 days of data acquisition approximately 1500
antiprotons were observed. The measurements are consistent with purely
secondary production of antiprotons in the galaxy. More precise secondary
production models are required for a complete interpretation of the results.Comment: 11 pages, 3 figures, 1 table. Accepted for publication in Physical
Review Letter
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The polygenic nature of telomere length and the anti-ageing properties of lithium
Telomere length is a promising biomarker for age-related disease and a potential anti-ageing drug target. Here, we study the genetic architecture of telomere length and the repositioning potential of lithium as an anti-ageing medication. LD score regression applied to the largest telomere length genome-wide association study to-date, revealed SNP-chip heritability estimates of 7.29%, with polygenic risk scoring capturing 4.4% of the variance in telomere length in an independent cohort (p = 6.17 × 10-5). Gene-enrichment analysis identified 13 genes associated with telomere length, with the most significant being the leucine rich repeat gene, LRRC34 (p = 3.69 × 10-18). In the context of lithium, we confirm that chronic use in a sample of 384 bipolar disorder patients is associated with longer telomeres (p = 0.03). As complementary evidence, we studied three orthologs of telomere length regulators in a Caenorhabditis elegans model of lithium-induced extended longevity and found all transcripts to be affected post-treatment (p 0.05). Consequently, this suggests that lithium may be catalysing the activity of endogenous mechanisms that promote telomere lengthening, whereby its efficacy eventually becomes limited by each individual's inherent telomere maintenance capabilities. Our work indicates a potential use of polygenic risk scoring for the prediction of adult telomere length and consequently lithium's anti-ageing efficacy
Hippocampal Gene Expression Analysis Highlights Ly6a/Sca-1 as Candidate Gene for Previously Mapped Novelty Induced Behaviors in Mice
In this study, we show that the covariance between behavior and gene expression in the brain can help further unravel the determinants of neurobehavioral traits. Previously, a QTL for novelty induced motor activity levels was identified on murine chromosome 15 using consomic strains. With the goal of narrowing down the linked region and possibly identifying the gene underlying the quantitative trait, gene expression data from this F2-population was collected and used for expression QTL analysis. While genetic variation in these mice was limited to chromosome 15, eQTL analysis of gene expression showed strong cis-effects as well as trans-effects elsewhere in the genome. Using weighted gene co-expression network analysis, we were able to identify modules of co-expressed genes related to novelty induced motor activity levels. In eQTL analyses, the expression of Ly6a (a.k.a. Sca-1) was found to be cis-regulated by chromosome 15. Ly6a also surfaced in a group of genes resulting from the network analysis that was correlated with behavior. Behavioral analysis of Ly6a knock-out mice revealed reduced novelty induced motor activity levels when compared to wild type controls, confirming functional importance of Ly6a in this behavior, possibly through regulating other genes in a pathway. This study shows that gene expression profiling can be used to narrow down a previously identified behavioral QTL in mice, providing support for Ly6a as a candidate gene for functional involvement in novelty responsiveness
How Many Supersymmetries?
Supersymmetry in the gauge sector could be realized as N=1 or N=2
Supersymmetry, but the current LHC searches assume an N=1 realization. In this
paper we show that squarks could be as light as few hundreds of GeV for N=2. We
also describe an experimental procedure to count the number of supersymmetries,
i.e. to distinguish between N=1 and N=2 supersymmetry, based on counting bins
with different jet multiplicities and number of leptons.Comment: 7 pages, 3 figure
A First Top Partner Hunter's Guide
We provide a systematic effective lagrangian description of the phenomenology of the lightest top-partners in composite Higgs models. Our construction is based on symmetry, on selection rules and on plausible dynamical assumptions. The structure of the resulting simplified models depends on the quantum numbers of the lightest top partner and of the operators involved in the generation of the top Yukawa. In all cases the phenomenology is conveniently described by a small number of parameters, and the results of experimental searches are readily interpreted as a test of naturalness. We recast presently available experimental bounds on heavy fermions into bounds on top partners: LHC has already stepped well inside the natural region of parameter space
Diagnosing Autism Spectrum Disorders in Adults: the Use of Autism Diagnostic Observation Schedule (ADOS) Module 4
Autism Diagnostic Observation Schedule (ADOS) module 4 was investigated in an independent sample of high-functioning adult males with an autism spectrum disorder (ASD) compared to three specific diagnostic groups: schizophrenia, psychopathy, and typical development. ADOS module 4 proves to be a reliable instrument with good predictive value. It can adequately discriminate ASD from psychopathy and typical development, but is less specific with respect to schizophrenia due to behavioral overlap between autistic and negative symptoms. However, these groups differ on some core items and explorative analyses indicate that a revision of the algorithm in line with Gotham et al. (J Autism Dev Disord 37: 613–627, 2007) could be beneficial for discriminating ASD from schizophrenia
Predictors of sun protection behaviours and sunburn among Australian adolescents
BACKGROUND: Excessive sun exposure and sunburn increase individuals' risk of skin cancer. It is especially important to prevent sunburn in childhood due to the higher relative risk of skin cancer across the life span compared to risk associated with sunburn episodes experienced later in life. This study examined demographic and attitudinal factors associated with engagement in a range of sun protection behaviours (wearing a hat, wearing protective clothing, staying in the shade, and staying indoors during the middle of the day) and the frequency of sunburn among Western Australian adolescents to provide insights of relevance for future sun protection campaigns. METHODS: Cross-sectional telephone surveys were conducted annually with Western Australians between 2005/06 and 2014/15. The results from 4150 adolescents aged 14-17 years were used to conduct a path analysis of factors predicting various sun protection behaviours and sunburn. RESULTS: Significant primary predictors of the sun protection behaviours included in the study were skin type (sun sensitivity), gender, tanning-related attitudes and behaviours, and perceived relevance of public service advertisements that advocate sun protection. Of the four sun protection behaviours investigated, staying in the shade and staying indoors during the middle of the day were associated with a lower frequency of sunburn. CONCLUSION: There is a particular need to target sun protection messages at adolescent males who are less likely to engage in the most effective sun protection behaviours and demonstrate an increased propensity to experience sunburn. The results suggest that such future sun protection messages should include a focus on the importance of staying in the shade or indoors during periods of high UV radiation to increase awareness of the efficacy of these methods of avoiding skin cancer
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