CHEX-MATE: CLUster Multi-Probes in Three Dimensions (CLUMP-3D), I. Gas Analysis Method using X-ray and Sunyaev-Zel'dovich Effect Data

Galaxy clusters are the products of structure formation through myriad physical processes that affect their growth and evolution throughout cosmic history. As a result, the matter distribution within galaxy clusters, or their shape, is influenced by cosmology and astrophysical processes, in particular the accretion of new material due to gravity. We introduce an analysis method to investigate the 3D triaxial shapes of galaxy clusters from the Cluster HEritage project with XMM-Newton -- Mass Assembly and Thermodynamics at the Endpoint of structure formation (CHEX-MATE). In this work, the first paper of a CHEX-MATE triaxial analysis series, we focus on utilizing X-ray data from XMM and Sunyaev-Zel'dovich (SZ) effect maps from Planck and ACT to obtain a three dimensional triaxial description of the intracluster medium (ICM) gas. We present the forward modeling formalism of our technique, which projects a triaxial ellipsoidal model for the gas density and pressure to compare directly with the observed two dimensional distributions in X-rays and the SZ effect. A Markov chain Monte Carlo is used to estimate the posterior distributions of the model parameters. Using mock X-ray and SZ observations of a smooth model, we demonstrate that the method can reliably recover the true parameter values. In addition, we apply the analysis to reconstruct the gas shape from the observed data of one CHEX-MATE galaxy cluster, Abell 1689, to illustrate the technique. The inferred parameters are in agreement with previous analyses for that cluster, and our results indicate that the geometrical properties, including the axial ratios of the ICM distribution, are constrained to within a few percent. With much better precision than previous studies, we thus further establish that Abell 1689 is significantly elongated along the line of sight, resulting in its exceptional gravitational lensing properties.Comment: submitted to A&A, comments welcom

In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide

Several essential oils exert in vitro activity against bacteria and viruses and, among these latter, herpes simplex virus type 1 (HSV-1) is known to develop resistance to commonly used antiviral agents. Thus, the effects of the essential oil derived from Mentha suaveolens (EOMS) and its active principle piperitenone oxide (PEO) were tested in in vitro experimental model of infection with HSV-1. The 50% inhibitory concentration (IC50) was determined at 5.1 mu g/ml and 1.4 mu g/ml for EOMS and PEO, respectively. Australian tea tree oil (TTO) was used as control, revealing an IC50 of 13.2 mu g/ml. Moreover, a synergistic action against HSV-1 was observed when each oil was added in combination with acyclovir. In order to find out the mechanism of action, EOMS, PEO and ITO were added to the cells at different times during the virus life-cycle. Results obtained by yield reduction assay indicated that the antiviral activity of both compounds was principally due to an effect after viral adsorption. Indeed, no reduction of virus yield was observed when cells were treated during viral adsorption or pre-treated before viral infection. In particular, PEO exerted a strong inhibitory effect by interfering with a late step of HSV-1 life-cycle. HSV-1 infection is known to induce a pro-oxidative state with depletion of the main intracellular antioxidant glutathione and this redox change in the cell is important for viral replication. Interestingly, the treatment with PEO corrected this deficit, thus suggesting that the compound could interfere with some redox-sensitive cellular pathways exploited for viral replication. Overall our data suggest that both EOMS and PEO could be considered good candidates for novel anti-HSV-1 strategies, and need further exploration to better characterize the targets underlying their inhibition. (C) 2014 Elsevier GmbH. All rights reserved

Molecular Epidemiology of Rotavirus in Central and Southeastern Europe▿

A surveillance network was implemented by the Istituto Superiore di Sanità of Rome in collaboration with laboratories of virology in Czech Republic, Slovenia, Croatia, Albania, and Bulgaria. About 1,500 rotavirus-positive stool samples were collected from children with severe gastroenteritis admitted to hospitals or outpatient wards between 2004 and 2006. The G and P genotypes were determined by reverse transcription-nested PCR. Significant differences were found in the geographical distributions of rotavirus genotypes between countries participating in the study. The prevalence of “common” G/P combinations, G1P[8], G3P[8], G4P[8], and G2P[4], ranged between 50 and 85%. The G9 genotype, which is emerging worldwide, was identified in 2 to 35% of all samples depending on the country. Unusual combinations, such as G1 or G4 associated with P[4] or G2 with P[8], which may have arisen by reassortment between human strains, were found in samples from 3 to 20% of patients. The uncommon genotypes G8P[8] and G10P[6], which may have an animal origin, were also identified. Double infections with two rotavirus strains were observed in between 1.7 and 14% of cases studied. Our findings might implicate challenges for rotavirus vaccine implementation in a wide geographic area of the Balkans and Central-Eastern Europe and underscore the importance of extensive strain surveillance for success in vaccine development

CHEX-MATE : turbulence in the ICM from X-ray surface brightness fluctuations

International audienceThe intra-cluster medium is prone to turbulent motion that will contribute to the non-thermal heating of the gas, complicating the use of galaxy clusters as cosmological probes. Indirect approaches can estimate the intensity and structure of turbulent motions by studying the associated fluctuations in gas density and X-ray surface brightness. In this work, we want to constrain the gas density fluctuations at work in the CHEX-MATE sample to obtain a detailed view of their properties in a large population of clusters. We use a simulation-based approach to constrain the parameters of the power spectrum of density fluctuations, assuming a Kolmogorov-like spectrum and including the sample variance, further providing an approximate likelihood for each cluster. This method requires clusters to be not too disturbed, as fluctuations can originate from dynamic processes such as merging. Accordingly, we remove the less relaxed clusters (centroid shift $w>0.02$) from our sample, resulting in a sample of 64 clusters. We define different subsets of CHEX-MATE to determine properties of density fluctuations as a function of dynamical state, mass and redshift, and investigate the correlation with the presence or not of a radio halo. We found a positive correlation between the dynamical state and density fluctuation variance, a non-trivial behaviour with mass and no specific trend with redshift or the presence/absence of a radio halo. The injection scale is mostly constrained by the core region. The slope in the inertial range is consistent with Kolmogorov theory. When interpreted as originating from turbulent motion, the density fluctuations in $R_{500}$ yield an average Mach number of $M_{3D}\simeq 0.4\pm 0.2$, an associated non-thermal pressure support of $P_{turb}/P_{tot}\simeq (9\pm 6) \%$ or a hydrostatic mass bias $b_{turb}\simeq 0.09\pm 0.06$, in line with what is expected from the literature

CHEX-MATE : turbulence in the ICM from X-ray surface brightness fluctuations

International audienceThe intra-cluster medium is prone to turbulent motion that will contribute to the non-thermal heating of the gas, complicating the use of galaxy clusters as cosmological probes. Indirect approaches can estimate the intensity and structure of turbulent motions by studying the associated fluctuations in gas density and X-ray surface brightness. In this work, we want to constrain the gas density fluctuations at work in the CHEX-MATE sample to obtain a detailed view of their properties in a large population of clusters. We use a simulation-based approach to constrain the parameters of the power spectrum of density fluctuations, assuming a Kolmogorov-like spectrum and including the sample variance, further providing an approximate likelihood for each cluster. This method requires clusters to be not too disturbed, as fluctuations can originate from dynamic processes such as merging. Accordingly, we remove the less relaxed clusters (centroid shift $w>0.02$) from our sample, resulting in a sample of 64 clusters. We define different subsets of CHEX-MATE to determine properties of density fluctuations as a function of dynamical state, mass and redshift, and investigate the correlation with the presence or not of a radio halo. We found a positive correlation between the dynamical state and density fluctuation variance, a non-trivial behaviour with mass and no specific trend with redshift or the presence/absence of a radio halo. The injection scale is mostly constrained by the core region. The slope in the inertial range is consistent with Kolmogorov theory. When interpreted as originating from turbulent motion, the density fluctuations in $R_{500}$ yield an average Mach number of $M_{3D}\simeq 0.4\pm 0.2$, an associated non-thermal pressure support of $P_{turb}/P_{tot}\simeq (9\pm 6) \%$ or a hydrostatic mass bias $b_{turb}\simeq 0.09\pm 0.06$, in line with what is expected from the literature

CHEX-MATE: Morphological analysis of the sample

In this work, we performed an analysis of the X-ray morphology of the 118 CHEX-MATE (Cluster HEritage project with XMM-Newton - Mass Assembly and Thermodynamics at the Endpoint of structure formation) galaxy clusters, with the aim to provide a classification of their dynamical state. To investigate the link between the X-ray appearance and the dynamical state, we considered four morphological parameters: the surface brightness concentration, the centroid shift, and the second- and third-order power ratios. These indicators result to be: strongly correlated with each other, powerful in identifying the disturbed and relaxed population, characterised by a unimodal distribution and not strongly influenced by systematic uncertainties. In order to obtain a continuous classification of the CHEX-MATE objects, we combined these four parameters in a single quantity, M, which represents the grade of relaxation of a system. On the basis of the M value, we identified the most extreme systems of the sample, finding 15 very relaxed and 27 very disturbed galaxy clusters. From a comparison with previous analysis on X-ray selected samples, we confirmed that the Sunyaev-Zeldovich (SZ) clusters tend to be more disturbed. Finally, by applying our analysis on a simulated sample, we found a general agreement between the observed and simulated results, with the only exception of the concentration. This latter behaviour, is partially related to the presence of particles with high smoothed-particle hydrodynamics density in the central regions of the simulated clusters due to the action of the idealised isotropic thermal Active Galactic Nuclei (AGN) feedback

CHEX-MATE: Morphological analysis of the sample

In this work, we performed an analysis of the X-ray morphology of the 118 CHEX-MATE (Cluster HEritage project with XMM-Newton - Mass Assembly and Thermodynamics at the Endpoint of structure formation) galaxy clusters, with the aim to provide a classification of their dynamical state. To investigate the link between the X-ray appearance and the dynamical state, we considered four morphological parameters: the surface brightness concentration, the centroid shift, and the second- and third-order power ratios. These indicators result to be: strongly correlated with each other, powerful in identifying the disturbed and relaxed population, characterised by a unimodal distribution and not strongly influenced by systematic uncertainties. In order to obtain a continuous classification of the CHEX-MATE objects, we combined these four parameters in a single quantity, M, which represents the grade of relaxation of a system. On the basis of the M value, we identified the most extreme systems of the sample, finding 15 very relaxed and 27 very disturbed galaxy clusters. From a comparison with previous analysis on X-ray selected samples, we confirmed that the Sunyaev-Zeldovich (SZ) clusters tend to be more disturbed. Finally, by applying our analysis on a simulated sample, we found a general agreement between the observed and simulated results, with the only exception of the concentration. This latter behaviour, is partially related to the presence of particles with high smoothed-particle hydrodynamics density in the central regions of the simulated clusters due to the action of the idealised isotropic thermal Active Galactic Nuclei (AGN) feedback

CHEX-MATE: Morphological analysis of the sample

In this work, we performed an analysis of the X-ray morphology of the 118 CHEX-MATE (Cluster HEritage project with XMM-Newton - Mass Assembly and Thermodynamics at the Endpoint of structure formation) galaxy clusters, with the aim to provide a classification of their dynamical state. To investigate the link between the X-ray appearance and the dynamical state, we considered four morphological parameters: the surface brightness concentration, the centroid shift, and the second- and third-order power ratios. These indicators result to be: strongly correlated with each other, powerful in identifying the disturbed and relaxed population, characterised by a unimodal distribution and not strongly influenced by systematic uncertainties. In order to obtain a continuous classification of the CHEX-MATE objects, we combined these four parameters in a single quantity, M, which represents the grade of relaxation of a system. On the basis of the M value, we identified the most extreme systems of the sample, finding 15 very relaxed and 27 very disturbed galaxy clusters. From a comparison with previous analysis on X-ray selected samples, we confirmed that the Sunyaev-Zeldovich (SZ) clusters tend to be more disturbed. Finally, by applying our analysis on a simulated sample, we found a general agreement between the observed and simulated results, with the only exception of the concentration. This latter behaviour, is partially related to the presence of particles with high smoothed-particle hydrodynamics density in the central regions of the simulated clusters due to the action of the idealised isotropic thermal Active Galactic Nuclei (AGN) feedback.Comment: 24 pages, 16 figures, 10 tables. Accepted for publication in A&

CHEX-MATE: CLUster Multi-Probes in Three Dimensions (CLUMP-3D), I. Gas Analysis Method using X-ray and Sunyaev-Zel'dovich Effect Data

International audienceGalaxy clusters are the products of structure formation through myriad physical processes that affect their growth and evolution throughout cosmic history. As a result, the matter distribution within galaxy clusters, or their shape, is influenced by cosmology and astrophysical processes, in particular the accretion of new material due to gravity. We introduce an analysis method to investigate the 3D triaxial shapes of galaxy clusters from the Cluster HEritage project with XMM-Newton -- Mass Assembly and Thermodynamics at the Endpoint of structure formation (CHEX-MATE). In this work, the first paper of a CHEX-MATE triaxial analysis series, we focus on utilizing X-ray data from XMM and Sunyaev-Zel'dovich (SZ) effect maps from Planck and ACT to obtain a three dimensional triaxial description of the intracluster medium (ICM) gas. We present the forward modeling formalism of our technique, which projects a triaxial ellipsoidal model for the gas density and pressure to compare directly with the observed two dimensional distributions in X-rays and the SZ effect. A Markov chain Monte Carlo is used to estimate the posterior distributions of the model parameters. Using mock X-ray and SZ observations of a smooth model, we demonstrate that the method can reliably recover the true parameter values. In addition, we apply the analysis to reconstruct the gas shape from the observed data of one CHEX-MATE galaxy cluster, Abell 1689, to illustrate the technique. The inferred parameters are in agreement with previous analyses for that cluster, and our results indicate that the geometrical properties, including the axial ratios of the ICM distribution, are constrained to within a few percent. With much better precision than previous studies, we thus further establish that Abell 1689 is significantly elongated along the line of sight, resulting in its exceptional gravitational lensing properties

CHEX-MATE: CLUster Multi-Probes in Three Dimensions (CLUMP-3D), I. Gas Analysis Method using X-ray and Sunyaev-Zel'dovich Effect Data

International audienceGalaxy clusters are the products of structure formation through myriad physical processes that affect their growth and evolution throughout cosmic history. As a result, the matter distribution within galaxy clusters, or their shape, is influenced by cosmology and astrophysical processes, in particular the accretion of new material due to gravity. We introduce an analysis method to investigate the 3D triaxial shapes of galaxy clusters from the Cluster HEritage project with XMM-Newton -- Mass Assembly and Thermodynamics at the Endpoint of structure formation (CHEX-MATE). In this work, the first paper of a CHEX-MATE triaxial analysis series, we focus on utilizing X-ray data from XMM and Sunyaev-Zel'dovich (SZ) effect maps from Planck and ACT to obtain a three dimensional triaxial description of the intracluster medium (ICM) gas. We present the forward modeling formalism of our technique, which projects a triaxial ellipsoidal model for the gas density and pressure to compare directly with the observed two dimensional distributions in X-rays and the SZ effect. A Markov chain Monte Carlo is used to estimate the posterior distributions of the model parameters. Using mock X-ray and SZ observations of a smooth model, we demonstrate that the method can reliably recover the true parameter values. In addition, we apply the analysis to reconstruct the gas shape from the observed data of one CHEX-MATE galaxy cluster, Abell 1689, to illustrate the technique. The inferred parameters are in agreement with previous analyses for that cluster, and our results indicate that the geometrical properties, including the axial ratios of the ICM distribution, are constrained to within a few percent. With much better precision than previous studies, we thus further establish that Abell 1689 is significantly elongated along the line of sight, resulting in its exceptional gravitational lensing properties