A Meta-Analysis for an Interactive, Intersectional and Inclusive Exhibition Based on the SDGs

The main goal of the project is to create an interactive exhibition, innovative and technological in its approach, that aims to create awareness and promote the knowledge of the Sustainable Development Goals of the Agenda ONU 2030 – in particular, on the value of social and environmental sustainability. 178 Countries adopted a common agenda to preserve our planet for the first time in 1992, during the Rio de Janeiro Summit. From that moment, the concept of sustainability has changed forever and has been changing ever since. In this paper, after understanding the state of the art in the field of the interactive exhibition, it is going to be explained how the methodology is applied in order to evolve from a desk and field analysis to a concept definition. These key points will then help define the concept in the shape of an operative strategy with methodological guidelines and a structured solution. From this stage, a few considerations on the future of this proposal can be drawn

A Meta-Analysis for an Interactive, Intersectional and Inclusive Exhibition Based on the SDGs

The main goal of the project is to create an interactive exhibition, innovative and technological in its approach, that aims to create awareness and promote the knowledge of the Sustainable Development Goals of the Agenda ONU 2030 – in particular, on the value of social and environmental sustainability. 178 Countries adopted a common agenda to preserve our planet for the first time in 1992, during the Rio de Janeiro Summit. From that moment, the concept of sustainability has changed forever and has been changing ever since. In this paper, after understanding the state of the art in the field of the interactive exhibition, it is going to be explained how the methodology is applied in order to evolve from a desk and field analysis to a concept definition. These key points will then help define the concept in the shape of an operative strategy with methodological guidelines and a structured solution. From this stage, a few considerations on the future of this proposal can be drawn

Vittorio Grevi - Scritti per il <<Corriere>> 1988-2010

Il volume contiene una selezione ragionata - preceduta da una prefazione di Virginio Rognoni - degli articoli di argomento giuridico scritti da Vittorio Grevi per Il Corriere della Sera nell'arco di tempo compreso tra il 1988 e il 2010, completata dall'indice generale di tutti gli articoli pubblicati, e dall'indice dei nomi citati

Sister chromatid exchange: A possible approach to characterize familial breast cancer patients

Sister chromatid exchange (SCE) frequency is widely used as an indicator of spontaneous chromosome instability. We investigated SCE frequency in the peripheral blood lymphocytes of familial and sporadic breast cancer (BC) patients from the Apulian Caucasian Population. Eighty-one patients were enrolled: 22 with familial history and 59 sporadic patients. Eleven familial patients had an 'increased risk' of BRCA gene mutation (BRCAPro &gt;= 10%) and were candidates for BRCA1 and BRCA2 mutation analysis. For these reasons, we stratified the 22 familial BC patients in two group: 'low-risk' (n=11) and 'high-risk' (n=11) patients for BRCA gene mutations. Two of these 11 'high-risk' patients (18%) had pathogenic mutations in the BRCA2 gene. The subjects were not cigarette smokers or alcohol or drug users, and had no genetic disorders or chronic diseases affecting the family. Our results showed a significant increase in SCE frequency in the familial (5.305 +/- 1.088/metaphase) (P&lt;0.0001) and the sporadic patients (3.943 +/- 0.552) (P&lt;0.0001) compared to the controls (3.197 +/- 0.649). We found that the SCE frequency was always significantly higher in familial than in sporadic patients, regardless of their clinicopathological characteristics. Moreover, we observed that the frequency of SCE in BRCA2 mutation carrier patients was higher compared to patients without mutations in BRCA1/2 genes. These findings highlight an intrinsic genomic instability in familial patients, and we suggest that SCE frequency may be used as a biomarker to better characterize familial BC

Multiple myeloma and paget disease with abnormal skull lesions and intracranial hypertension

: We report a 73 years old man with a diagnosis of Paget Disease (PD) and symptomatic Multiple Myeloma (MM). Coexistence of MM and PD has rarely been described. PD mimics many of the features of bone destructive process in MM, making differential diagnosis more complicated. In addition, the presence of serious muscolo-skeletal and metabolic complications in both diseases makes management of patients difficult, worsening the prognosis.The comparison of these two diseases has led to the characterization of a common molecular mechanism represented by the receptor activator of nuclear factor-kB ligand (RANKL)/Osteoprotegerin signaling pathway. The improved comprehension of these mechanisms led to the development of new pharmacologic agents (bisphosphonates, cytokines inhibitors) effective for the treatment of these bone diseases

Treatment with direct-acting antivirals improves the clinical outcome in patients with HCV-related decompensated cirrhosis: results from an Italian real-life cohort (Liver Network Activity—LINA cohort)

Direct-acting antivirals (DAAs) are safe and effective for the treatment of HCV infection. However, data regarding their efficacy in patients with Child-Pugh B cirrhosis are scarce and their capability in improving liver function is debated. The aim of our study was to assess the clinical benefits of treatment with DAA in subjects with Child-Pugh B cirrhosis

Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts.

The goal of cancer chemotherapy is targeting tumor cells and/or tumor-associated microvessels with the lowest systemic toxicity. Mesenchymal stromal cells (MSCs) are promising vehicles for selective drug delivery due to their peculiar ability to home to pathological tissues. We previously showed that MSCs are able to uptake and subsequently to release the chemotherapeutic compound Paclitaxel (PTX) and to impair the growth of subcutaneous glioblastoma multiforme (GBM) xenografts. Here we used an orthotopic GBM model 1) to assess whether PTX-loaded MSCs (PTX-MSCs) retain a tropism towards the tumor cells in the brain context, and 2) to characterize the cytotoxic damage induced by MSCs-driven PTX release in the tumor microenvironment. METHODS: U87MG GBM cells were fluorescently labeled with the mCherry protein and grafted onto the brain of immunosuppressed rats. In adjacent brain regions, we injected green fluorescent protein-expressing murine MSCs, either loaded with PTX or unloaded. After 1 week survival, the xenografted brain was assessed by confocal microscopy for PTX-induced cell damage. RESULTS: Overall, MSCs showed remarkable tropism towards the tumor. In rats grafted with PTX-MSCs, the nuclei of U87MG cells showed changes that are typically induced by PTX, including multi-spindle mitoses, centrosome number alterations, and nuclear fragmentation. Multi-spindle mitoses resulted in multinucleated cells that were significantly higher in tumors co-grafted with PTX-MSCs than in controls. Nuclear changes did not occur in astrocytes and neurons surrounding the tumor. CONCLUSIONS: MSCs appear particularly suited for anti-neoplastic drug delivery in the brain since PTX-specific damage of GBM cells can be achieved avoiding side effects to the normal tissue

Additional file 1: Figure S1. of Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts

Showing in vitro U87MG cell viability after treatment with CM from PTX-loaded MSCs. The kinetics of growth inhibition induced by serial 1:2 dilutions of CM from PTX-loaded MSCs on U87MG cells is compared with the growth inhibition of U87MG cells caused by PTX treatment at different concentrations (in the range of 1.56–200 ng/ml). The addition of CM induced a strong anti-proliferative effect in a dose-dependent fashion. Mean ± standard deviation are shown. (JPEG 293 kb