17 research outputs found

    El papel morfogenético dominante de la escorrentía superficial en Licus Vallis, Marte: Resultados del análisis geomorfológico y morfométrico

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    Se ha analizado la cuenca de Licus Vallis, un antiguo cauce situado en la región ecuatorial de Marte, con la finalidad de evaluar el papel morfogenético que tuvo el agua superficial en su desarrollo. El análisis geomorfológico llevado a cabo en un entorno SIG ha permitido identificar numerosas morfologías fluviales relictas como canales, terrazas simétricas y un delta. Licus Vallis presenta una cuenca con rasgos propios de un relieve joven, con un perfil en desequilibrio, canales de cuarto orden, valles en V, una densidad de drenaje muy baja, y un patrón dendrítico. La erosión generada por la escorrentía superficial parece ser el proceso dominante en la formación de Licus Vallis. Sin embargo, la presencia de valles con cabecera semicircular parece indicar que la erosión asociada a surgencias pudo contribuir a la expansión por erosión remontante de los valles. Además, el hallazgo, por primera vez en este trabajo, de un posible delta de tipo Gilberten la desembocadura del sistema fluvial permitió definir el nivel de base de la cuenca y plantear la posible existencia de un antiguo mar en la región. A watershed analysis was performed to assess the morphogenetic role of surface water on the development of Licus Vallis, an ancient river valley located in the equatorial region of Mars. Terrain analysis in a GIS environment allowed the identification of numerous relict fluvial features such as channels, paired terraces and a delta. Licus Vallis has the characteristics of a young watershed with a non-equilibrium profile, fourth-order streams, V-shaped valleys, very low drainage density, and a dendritic drainage pattern. Erosion related to surface runoff appears to be the dominant process involved in the formation of Licus Vallis. Nevertheless, the presence of theatre-like valley heads seems to indicate that sapping erosion associated with springs may have played some role in the headward expansion of valleys. Moreover, the finding, for the first time in this work, of a possible Gilbert-type delta at the mouth of the fluvial system permitted to define the paleobase level of the drainage basin and suggests the existence of an ancient sea in the region

    Expert recommendations on the management of patients with metastatic castration-resistant prostate cancer who progress after CHAARTED or LATITUDE

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    Objective: Our aim was to provide practical recommendations on the management of patients with metastatic castration-resistant prostate cancer (mCRPC) who have progressed after docetaxel plus androgen-deprivation therapy (ADT) or abiraterone plus ADT. Methods: Systematic literature review (SLR), nominal group meeting, and Delphi process. A panel of 12 experts was established who defined the scope, users, and sections of the document. We performed an SLR in order to assess the efficacy and safety of available drugs in patients with mCRPC. Abstracts from the American Society of Oncology and European Society for Medical Oncology meetings were also examined. The results were discussed during an expert meeting in which 14 recommendations were generated. The level of agreement with the recommendations was also tested by 13 additional experts following the Delphi process. Recommendations were voted by means of scores ranging from 0 (total disagreement) to 10 (total agreement). We defined agreement when at least 70% of the experts voted ¿7. Next, we assigned a level of evidence and grade to the recommendation using the Oxford Centre for Evidence-based Medicine Levels of Evidence, following which the final document was drafted. Results: The literature search did not find any articles meeting the inclusion criteria. Finally, 13 out of 14 recommendations were accepted after two Delphi rounds (two were modified after the first round). They pertain to general and individual case-based treatment recommendations. Conclusions: In mCRPC patients who have progressed after docetaxel or abiraterone plus ADT in the metastatic hormone-sensitive prostate cancer setting, these recommendations may support treatment decision-making, due to the lack of evidence or other globally accepted sequencing algorithms

    First Assessment of the Impacts of the COVID-19 Pandemic on Global Marine Recreational Fisheries

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    This work is the result of an international research effort to determine the main impacts of the COVID-19 pandemic on marine recreational fishing. Changes were assessed on (1) access to fishing, derived from lockdowns and other mobility restrictions; (2) ecosystems, because of alterations in fishing intensity and human presence; (3) the blue economy, derived from alterations in the investments and expenses of the fishers; and (4) society, in relation to variations in fishers’ health and well-being. For this, a consultation with experts from 16 countries was carried out, as well as an international online survey aimed at recreational fishers, that included specific questions designed to capture fishers’ heterogeneity in relation to behavior, skills and know-how, and vital involvement. Fishers’ participation in the online survey (5,998 recreational fishers in 15 countries) was promoted through a marketing campaign. The sensitivity of the fishers’ clustering procedure, based on the captured heterogeneity, was evaluated by SIMPER analysis and by generalized linear models. Results from the expert consultation highlighted a worldwide reduction in marine recreational fishing activity. Lower human-driven pressures are expected to generate some benefits for marine ecosystems. However, experts also identified high negative impacts on the blue economy, as well as on fisher health and well-being because of the loss of recreational fishing opportunities. Most (98%) of the fishers who participated in the online survey were identified as advanced, showing a much higher degree of commitment to recreational fishing than basic fishers (2%). Advanced fishers were, in general, more pessimistic about the impacts of COVID-19, reporting higher reductions in physical activity and fish consumption, as well as poorer quality of night rest, foul mood, and raised more concerns about their health status. Controlled and safe access to marine recreational fisheries during pandemics would provide benefits to the health and well-being of people and reduce negative socioeconomic impacts, especially for vulnerable social groups.Versión del edito

    Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

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    Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited

    Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

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    Objetivo Evaluar el grado de seguimiento de las recomendaciones de las versiones de la Guía española para el manejo del asma (GEMA 2009 y 2015) y su repercusión en el control de la enfermedad. Material y métodos Estudio observacional y ambispectivo realizado entre septiembre del 2015 y abril del 2016, en el que participaron 314 médicos de atención primaria y 2.864 pacientes. Resultados Utilizando datos retrospectivos, 81 de los 314 médicos (25, 8% [IC del 95%, 21, 3 a 30, 9]) comunicaron seguir las recomendaciones de la GEMA 2009. Al inicio del estudio, 88 de los 314 médicos (28, 0% [IC del 95%, 23, 4 a 33, 2]) seguían las recomendaciones de la GEMA 2015. El tener un asma mal controlada (OR 0, 19, IC del 95%, 0, 13 a 0, 28) y presentar un asma persistente grave al inicio del estudio (OR 0, 20, IC del 95%, 0, 12 a 0, 34) se asociaron negativamente con tener un asma bien controlada al final del seguimiento. Por el contrario, el seguimiento de las recomendaciones de la GEMA 2015 se asoció de manera positiva con una mayor posibilidad de que el paciente tuviera un asma bien controlada al final del periodo de seguimiento (OR 1, 70, IC del 95%, 1, 40 a 2, 06). Conclusiones El escaso seguimiento de las guías clínicas para el manejo del asma constituye un problema común entre los médicos de atención primaria. Un seguimiento de estas guías se asocia con un control mejor del asma. Existe la necesidad de actuaciones que puedan mejorar el seguimiento por parte de los médicos de atención primaria de las guías para el manejo del asma. Objective: To assess the degree of compliance with the recommendations of the 2009 and 2015 versions of the Spanish guidelines for managing asthma (Guía Española para el Manejo del Asma [GEMA]) and the effect of this compliance on controlling the disease. Material and methods: We conducted an observational ambispective study between September 2015 and April 2016 in which 314 primary care physicians and 2864 patients participated. Results: Using retrospective data, we found that 81 of the 314 physicians (25.8%; 95% CI 21.3–30.9) stated that they complied with the GEMA2009 recommendations. At the start of the study, 88 of the 314 physicians (28.0%; 95% CI 23.4–33.2) complied with the GEMA2015 recommendations. Poorly controlled asthma (OR, 0.19; 95% CI 0.13–0.28) and persistent severe asthma at the start of the study (OR, 0.20; 95% CI 0.12–0.34) were negatively associated with having well-controlled asthma by the end of the follow-up. In contrast, compliance with the GEMA2015 recommendations was positively associated with a greater likelihood that the patient would have well-controlled asthma by the end of the follow-up (OR, 1.70; 95% CI 1.40–2.06). Conclusions: Low compliance with the clinical guidelines for managing asthma is a common problem among primary care physicians. Compliance with these guidelines is associated with better asthma control. Actions need to be taken to improve primary care physician compliance with the asthma management guidelines

    The dominant morphogenetic role of surface runoff in Licus Vallis, Mars: results from geomorphological and morphometric analyses.

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    A watershed analysis was performed to assess the morphogenetic role of surface water on the development of Licus Vallis, an ancient river valley located in the equatorial region of Mars. Terrain analysis in a GIS environment allowed the identification of numerous relict fluvial features such as channels, paired terraces and a delta. Licus Vallis has the characteristics of a young watershed with a non-equilibrium profile, fourth-order streams, Vshaped valleys, very low drainage density, and a dendritic drainage pattern. Erosion related to surface runoff appears to be the dominant process involved in the formation of Licus Vallis. Nevertheless, the presence of theatre-like valley heads seems to indicate that sapping erosion associated with springs may have played some role in the headward expansion of valleys. Moreover, the finding, for the first time in this work, of a possible Gilbert-type delta at the mouth of the fluvial system permitted to define the paleobase level of the drainage basin and suggests the existence of an ancient sea in the region Se ha analizado la cuenca de Licus Vallis, un antiguo cauce situado en la región ecuatorial de Marte, con la finalidad de evaluar el papel morfogenético que tuvo el agua superficial en su desarrollo. El análisis geomorfológico llevado a cabo en un entorno SIG ha permitido identificar numerosas morfologías fluviales relictas como canales, terrazas simétricas y un delta. Licus Vallis presenta una cuenca con rasgos propios de un relieve joven, con un perfil en desequilibrio, canales de cuarto orden, valles en V, una densidad de drenaje muy baja, y un patrón dendrítico. La erosión generada por la escorrentía superficial parece ser el proceso dominante en la formación de Licus Vallis. Sin embargo, la presencia de valles con cabecera semicircular parece indicar que la erosión asociada a surgencias pudo contribuir a la expansión por erosión remontante de los valles. Además, el hallazgo, por primera vez en este trabajo, de un posible delta de tipo Gilberten la desembocadura del sistema fluvial permitió definir el nivel de base de la cuenca y plantear la posible existencia de un antiguo mar en la regió
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