3,769 research outputs found
Breve reseña de los principales académicos de la Real de Buenas Letras que escribieron obras literarias en lengua castellana
WUVS Simulator: Detectability of spectral lines with the WSO-UV spectrographs
The World Space Observatory - Ultraviolet (WSO-UV) space telescope is
equipped with high dispersion (55,000) spectrographs working in the 1150-3100
{\AA} spectral range. To evaluate the impact of the design on the scientific
objectives of the mission, a simulation software tool has been developed. This
simulator builds on the development made for the PLATO space mission, and it is
designed to generate synthetic time-series of images by including models of all
important noise sources. In this article, we describe its design and
performance. Moreover, its application to the detectability of important
spectral features for star formation and exoplanetary research is addressed.Comment: 8 pages, 5 figure
Robustness of Pseudomonas 1 putida KT2440 as a host for ethanol 2 biosynthesis
Expansion of the burgeoning biofuels agenda involves not only the design of suitable genetic and metabolic devices but also their deployment into suitable hosts that can endure the stress brought about by the products themselves. The microorganisms easiest to genetically manipulate for these endeavours (e.g., Escherichia coli) are often afflicted by an undesirable sensitivity to the very product that they are engineered to synthesize. In this context, we have examined the resistance to the stress arising from ethanol synthesis and/or its addition to cultures of recombinant Pseudomonas putida, using as a benchmark the same trait in an E. coli strain. To this end, ethanologenic strains of these two species were constructed by functionally expressing pdc (pyruvate decarboxylase) and adhB (alcohol dehydrogenase) from Zymomonas mobilis. Recombinants were compared under anoxic conditions as ethanol producers, and cell survival, stress resistance, and phenotypic stability were quantified in each case. P. putida consistently outperformed E. coli in every ethanol tolerance test conducted – whether the alcohol was produced endogenously or added exogenously. These results highlight the value of such bacterium as a microbial cell factory for the production of biofuels owing to its naturally preevolved ability to withstand different kinds of chemical stresses.This study was supported by the BIO Program of the Spanish Ministry of Economy and Competitiveness, the ST-FLOW and ARIAYS Contracts of the EU, and the PROMT Project of the CAM.Peer reviewe
Pyridine nucleotide transhydrogenases enable redox balance of Pseudomonas putida during biodegra dation of aromatic compounds
Supporting informationThe metabolic versatility of the soil bacterium Pseudomonas putida is reflected by its ability to execute strong redox reactions (e.g., mono- and di-oxygenations) on aromatic substrates. Biodegradation of aromatics occurs via the pathway encoded in the archetypal TOL plasmid pWW0, yet the effect of running such oxidative route on redox balance against the background metabolism of P. putida remains unexplored. To answer this question, the activity of pyridine nucleotide transhydrogenases (that catalyze the reversible interconversion of NADH and NADPH) was inspected under various physiological and oxidative stress regimes. The genome of P. putida KT2440 encodes a soluble transhydrogenase (SthA) and a membrane-bound, proton-pumping counterpart (PntAB). Mutant strains, lacking sthA and/or pntAB, were subjected to a panoply of genetic, biochemical, phenomic and functional assays in cells grown on customary carbon sources (e.g., citrate) versus difficult-to-degrade aromatic substrates. The results consistently indicated that redox homeostasis is compromised in the transhydrogenases-defective variant, rendering the mutant sensitive to oxidants. This metabolic deficiency was, however, counteracted by an increase in the activity of NADP+ -dependent dehydrogenases in central carbon metabolism. Taken together, these observations demonstrate that transhydrogenases enable a redox-adjusting mechanism that comes into play when biodegradation reactions are executed to metabolize unusual carbon compounds.This work was supported by the EVOPROG (FP7-ICT-610730), ARISYS (ERC-2012-ADG-322797) and EmPowerPutida (EU-H2020-BIOTEC-2014-2015-6335536),
Contracts of the European Union, and the CAMBIOS (RTC-2014-1777-3) and CONTIBUGS (PCIN-2013-040) projects of the Spanish Ministry of Economy and Competitiveness.Peer reviewe
Strong Shock Waves and Nonequilibrium Response in a One-dimensional Gas: a Boltzmann Equation Approach
We investigate the nonequilibrium behavior of a one-dimensional binary fluid
on the basis of Boltzmann equation, using an infinitely strong shock wave as
probe. Density, velocity and temperature profiles are obtained as a function of
the mixture mass ratio \mu. We show that temperature overshoots near the shock
layer, and that heavy particles are denser, slower and cooler than light
particles in the strong nonequilibrium region around the shock. The shock width
w(\mu), which characterizes the size of this region, decreases as w(\mu) ~
\mu^{1/3} for \mu-->0. In this limit, two very different length scales control
the fluid structure, with heavy particles equilibrating much faster than light
ones. Hydrodynamic fields relax exponentially toward equilibrium, \phi(x) ~
exp[-x/\lambda]. The scale separation is also apparent here, with two typical
scales, \lambda_1 and \lambda_2, such that \lambda_1 ~ \mu^{1/2} as \mu-->0$,
while \lambda_2, which is the slow scale controlling the fluid's asymptotic
relaxation, increases to a constant value in this limit. These results are
discussed at the light of recent numerical studies on the nonequilibrium
behavior of similar 1d binary fluids.Comment: 9 pages, 8 figs, published versio
Hamiltonian systems with orbits covering densely submanifolds of small codimension
The existence of a transition chain in a Hamiltonian system leads to the existence of orbits shadowing it, if some lambda lemma can be applied. This fact has been used to prove the existence of diffusion in perturbations of integrable a priori stable systems. We prove that, under suitable conditions, there are orbits which cover densely codimension two submanifolds of the (2n - 1)-dimensional energy level. We also construct examples, near general integrable systems, where the computations to verify the sufficient conditions for the appearance of such phenomenon can be performed
An (Un)feasible Gay Planet. The Vital Intercession of Women in the Continuity of Athos in Lois McMaster Bujold's Ethan of Athos
Lois McMaster Bujold's Ethan of Athos (1986) portrays a planet only habitable by men in which homosexuality is the norm rather than celibacy, also contemplated. Nevertheless, women are not permitted to participate in this gay society since they are seen by Athosians as creatures that only bring misfortunes and jeopardize the system that governs the planet. Regardless of the fact that the autor does provide a number of eutopian elements that can be found in Athos, its exacerbated misogynistic doctrine highlights its dystopian aspects. By analysing both the eutopian and dystopian features of Athos, I argue, that the autor is not concerned with portraying either an eutopia or a dystopia as much as she is concerned with leading an Athosian, the protagonist Ethan, to acknowledge that Athos' existence cannot occur without women. As a tool to destroy Ethan's unfounded misogyny, Bujold utilises the friendship between Ethan and female mercenary Elli Quinn. In this process, Elli Quinn arises as the real hero of the novel since she not only helps and protects Ethan but also provides Athos with a priceless gift, her own ova.La novela Ethan de Athos (1986) de Lois McMaster Bujold recrea un planeta solo habitado por hombres en el que la homosexualidad es la norma a pesar de que el celibato también sea contemplado. No obstante, las mujeres no pueden participar en esta sociedad gay ya que son vistas por los Athosianos como criaturas que solo traen infortunios y que ponen en peligro el sistema que rige el planeta. Independientemente de que la autora sà introduce cierto número de elementos eutópicos que pueden ser encontrados en Athos, la exacerbada misoginia del planeta subraya sus aspectos más distópicos. Mediante el análisis de los elementos tanto eutópicos como distópicos, argumento que la autora no está preocupada en recrear ni una eutopia ni una distopÃa sino que lo que más le interesa es llevar a un Athosiano, el protagonista Ethan, a reconocer que la existencia de Athos no puede ocurrir sin mujeres. Como herramienta para desmoronar la misoginia sin fundamento de Ethan, Bujold utiliza la amistad entre Ethan y la mercenaria Elli Quinn. En este proceso, Elli Quinn se eleva como la verdadera heroÃna de la novela puesto que no solo ayuda y protege a Ethan sino que también proporciona a Athos un regalo inconmensurable, sus propios ovarios.La novel·la Ethan de Athos (1986) de Lois McMaster Bujold representa un planeta només habitat per homes en el qual l'homosexualitat és la norma malgrat que el celibat també sigui contemplat. No obstant això, les dones no poden participar en aquesta societat gai ja que són vistes pels Athosians com a criatures que únicament porten infortunis i que posen en perill el sistema que regeix el planeta. Independentment que l'autora sà introdueix cert nombre d'elements eutòpics que poden ser trobats en Athos, l'exacerbada misogÃnia del planeta subratlla els seus aspectes més distòpics. Mitjançant l'anà lisi dels elements tant eutòpics com distòpics, argument que l'autora no es preocupa de reprodueix ni una eutopia ni una distopia sinó que el que més li interessa és portar a un Athosià , el protagonista Ethan, a reconèixer que l'existència de Athos no pot ocórrer sense dones. Com a eina per enfonsar la misogÃnia sense fonament de Ethan, Bujold utilitza l'amistat entre Ethan i la mercenà ria Elli Quinn. En aquest procés, Elli Quinn s'eleva com la veritable heroÃna de la novel·la que no solament ajuda i protegeix a Ethan sinó que també proporciona a Athos un regal incommensurable, els seus propis ovaris
El col·leccionisme d’antiguitats com a mitjà de promoció social: el cas de Josep de Maranges i Marimon. Anà lisi del Compendio histórico, resumen y descripción de la antiquisima ciudad de Empurias
L’antiquarisme clà ssic fou una eina de promoció social durant
la Il·lustració. Un món associat també als estudis d’història antiga.
Aquest article dóna mostra d’això a partir de Josep de Maranges
i Marimon i el seu Compendio. L’obra aporta noves dades sobre
la seva biografia i analitza les motivacions que el dugueren a
escriure-la. La primera redacció del Compendio es relaciona amb
una oferta al PrÃncep d’Astúries d’una col·lecció d’antiguitats reco-
llida per Maranges. Això no fou una estratègia aïllada. La famÃlia
Maranges anteriorment ja havia utilitzat aquest recurs per obrir-se
nous cercles socials
Grand canonical and canonical solution of self-avoiding walks with up to three monomers per site on the Bethe lattice
We solve a model of polymers represented by self-avoiding walks on a lattice
which may visit the same site up to three times in the grand-canonical
formalism on the Bethe lattice. This may be a model for the collapse transition
of polymers where only interactions between monomers at the same site are
considered. The phase diagram of the model is very rich, displaying coexistence
and critical surfaces, critical, critical endpoint and tricritical lines, as
well as a multicritical point. From the grand-canonical results, we present an
argument to obtain the properties of the model in the canonical ensemble, and
compare our results with simulations in the literature. We do actually find
extended and collapsed phases, but the transition between them, composed by a
line of critical endpoints and a line of tricritical points, separated by the
multicritical point, is always continuous. This result is at variance with the
simulations for the model, which suggest that part of the line should be a
discontinuous transition. Finally, we discuss the connection of the present
model with the standard model for the collapse of polymers (self-avoiding
self-attracting walks), where the transition between the extended and collapsed
phases is a tricritical point.Comment: 34 pages, including 10 figure
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