2,155 research outputs found
Economic Interplay Forecasting Business Success
A startup ecosystem is a dynamic environment in which several actors, such as investors, venture capitalists, angels, and facilitators, are the protagonists of a complex interplay. Most of these interactions involve the flow of capital whose size and direction help to map the intricate system of relationships. This quantity is also considered a good proxy of economic success. Given the complexity of such systems, it would be more desirable to supplement this information with other informative features, and a natural choice is to adopt mathematical measures. In this work, we will specifically consider network centrality measures, borrowed by network theory. In particular, using the largest publicly available dataset for startups, the Crunchbase dataset, we show how centrality measures highlight the importance of particular players, such as angels and accelerators, whose role could be underestimated by focusing on collected funds only. We also provide a quantitative criterion to establish which firms should be considered strategic and rank them. Finally, as funding is a widespread measure for success in economic settings, we investigate to which extent this measure is in agreement with network metrics; the model accurately forecasts which firms will receive the highest funding in future years
Capital Regulation, Liquidity Requirements and Taxation in a Dynamic Model of Banking
This paper formulates a dynamic model of a bank exposed to both credit and liquidity risk, which can resolve financial distress in three costly forms: fire sales, bond issuance and equity issuance. We use the model to analyze the impact of capital regulation, liquidity requirements and taxation on banks' optimal policies and metrics of efficiency of intermediation and social value. We obtain three main results. First, mild capital requirements increase bank lending, bank efficiency and social value relative to an unregulated bank, but these benefits turn into costs if capital requirements are too stringent. Second, liquidity requirements reduce bank lending, efficiency and social value significantly, they nullify the benefits of mild capital requirements, and their private and social costs increase monotonically with their stringency. Third, increases in corporate income and bank liabilities taxes reduce bank lending, bank efficiency and social value, with tax receipts increasing with the former but decreasing with the latter. Moreover, the effects of an increase in both forms of taxation are dampened if they are jointly implemented with increases in capital and liquidity requirements
Data on the stability of darunavir/cobicistat suspension after tablet manipulation
The COVID-19 outbreak is now one of the most critical crises to manage for most of the national healthcare systems in the world. In the absence of authorised pharmacological treatments, many antiretrovirals, including darunavir/cobicistat fixed combination, are used off-label in the hospital wards as life-treating medicines for COVID-19 patients. Unfortunately, for most of them, the drug products available on the market are not designed to be administered by a nasogastric tube to inpatients of intensive care units. Therefore, their manipulation, even if it can strongly affect the product quality, is necessary for the preparation of suspension to meet patients\u2019 need. In this situation, it is urgent to provide data and guidance to support hospital pharmacists and clinicians in their activity. The data in this article indicate that darunavir/cobicistat suspensions compounded by pharmacists using as active ingredient a commercially available tablet can be stable at least for one week
A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function
Initial Results from the CHOOZ Long Baseline Reactor Neutrino Oscillation Experiment
Initial results are presented from CHOOZ, a long-baseline reactor-neutrino
vacuum-oscillation experiment. Electron antineutrinos were detected by a liquid
scintillation calorimeter located at a distance of about 1 km. The detector was
constructed in a tunnel protected from cosmic rays by a 300 MWE rock
overburden. This massive shielding strongly reduced potentially troublesome
backgrounds due to cosmic-ray muons, leading to a background rate of about one
event per day, more than an order of magnitude smaller than the observed
neutrino signal. From the statistical agreement between detected and expected
neutrino event rates, we find (at 90% confidence level) no evidence for
neutrino oscillations in the electron antineutrino disappearance mode for the
parameter region given approximately by deltam**2 > 0.9 10**(-3) eV**2 for
maximum mixing and (sin(2 theta)**2) > 0.18 for large deltam**2.Comment: 13 pages, Latex, submitted to Physics Letters
Search for neutrino oscillations on a long base-line at the CHOOZ nuclear power station
This final article about the CHOOZ experiment presents a complete description
of the electron antineutrino source and detector, the calibration methods and
stability checks, the event reconstruction procedures and the Monte Carlo
simulation. The data analysis, systematic effects and the methods used to reach
our conclusions are fully discussed. Some new remarks are presented on the
deduction of the confidence limits and on the correct treatment of systematic
errors.Comment: 41 pages, 59 figures, Latex file, accepted for publication by
Eur.Phys.J.
Final results of magnetic monopole searches with the MACRO experiment
We present the final results obtained by the MACRO experiment in the search
for GUT magnetic monopoles in the penetrating cosmic radiation, for the range
. Several searches with all the MACRO sub-detectors
(i.e. scintillation counters, limited streamer tubes and nuclear track
detectors) were performed, both in stand alone and combined ways. No candidates
were detected and a 90% Confidence Level (C.L.) upper limit to the local
magnetic monopole flux was set at the level of cm
s sr. This result is the first experimental limit obtained in
direct searches which is well below the Parker bound in the whole range
in which GUT magnetic monopoles are expected.Comment: 12 pages, Latex, 9 figures and 2 Table
Muon Energy Estimate Through Multiple Scattering with the Macro Detector
Muon energy measurement represents an important issue for any experiment
addressing neutrino induced upgoing muon studies. Since the neutrino
oscillation probability depends on the neutrino energy, a measurement of the
muon energy adds an important piece of information concerning the neutrino
system. We show in this paper how the MACRO limited streamer tube system can be
operated in drift mode by using the TDC's included in the QTPs, an electronics
designed for magnetic monopole search. An improvement of the space resolution
is obtained, through an analysis of the multiple scattering of muon tracks as
they pass through our detector. This information can be used further to obtain
an estimate of the energy of muons crossing the detector. Here we present the
results of two dedicated tests, performed at CERN PS-T9 and SPS-X7 beam lines,
to provide a full check of the electronics and to exploit the feasibility of
such a multiple scattering analysis. We show that by using a neural network
approach, we are able to reconstruct the muon energy for 40 GeV. The
test beam data provide an absolute energy calibration, which allows us to apply
this method to MACRO data.Comment: 25 pages, 11 figures, Submitted to Nucl. Instr. & Meth.
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