Quantum Degenerate Systems

Degenerate dynamical systems are characterized by symplectic structures whose rank is not constant throughout phase space. Their phase spaces are divided into causally disconnected, nonoverlapping regions such that there are no classical orbits connecting two different regions. Here the question of whether this classical disconnectedness survives quantization is addressed. Our conclusion is that in irreducible degenerate systems --in which the degeneracy cannot be eliminated by redefining variables in the action--, the disconnectedness is maintained in the quantum theory: there is no quantum tunnelling across degeneracy surfaces. This shows that the degeneracy surfaces are boundaries separating distinct physical systems, not only classically, but in the quantum realm as well. The relevance of this feature for gravitation and Chern-Simons theories in higher dimensions cannot be overstated.Comment: 18 pages, no figure

PPLN Waveguide for Quantum Communication

We report on energy-time and time-bin entangled photon-pair sources based on a periodically poled lithium niobate (PPLN) waveguide. Degenerate twin photons at 1314 nm wavelength are created by spontaneous parametric down-conversion and coupled into standard telecom fibers. Our PPLN waveguide features a very high conversion efficiency of about 10^(-6), roughly 4 orders of magnitude more than that obtained employing bulk crystals. Even if using low power laser diodes, this engenders a significant probability for creating two pairs at a time - an important advantage for some quantum communication protocols. We point out a simple means to characterize the pair creation probability in case of a pulsed pump. To investigate the quality of the entangled states, we perform photon-pair interference experiments, leading to visibilities of 97% for the case of energy-time entanglement and of 84% for the case of time-bin entanglement. Although the last figure must still be improved, these tests demonstrate the high potential of PPLN waveguide based sources to become a key element for future quantum communication schemesComment: 11 pages, 9 figures, submitted to the European Physical Journal D (special issue of the Quick conference

RAPD markers in wild and cultivated Vitis vinifera

Some Vitis vinifera cultivars and V. vinifera ssp. silvestris individuals have been subjected to the RAPD analysis in order to estimate the genetic diversity existing within this germplasm. 44 decamer primers of arbitrary sequence have been used for PCR and reproducible band profiles have been obtained. The distribution of the individualized polymorphic DNA markers has not turned out to be different in a remarkable way between cultivated and wild grapevines but this RAPD approach provides for some characteristics useful to analyze genetic relationships even within the Vitis vinifera species

Nature-Inspired Interconnects for Self-Assembled Large-Scale Network-on-Chip Designs

Future nano-scale electronics built up from an Avogadro number of components needs efficient, highly scalable, and robust means of communication in order to be competitive with traditional silicon approaches. In recent years, the Networks-on-Chip (NoC) paradigm emerged as a promising solution to interconnect challenges in silicon-based electronics. Current NoC architectures are either highly regular or fully customized, both of which represent implausible assumptions for emerging bottom-up self-assembled molecular electronics that are generally assumed to have a high degree of irregularity and imperfection. Here, we pragmatically and experimentally investigate important design trade-offs and properties of an irregular, abstract, yet physically plausible 3D small-world interconnect fabric that is inspired by modern network-on-chip paradigms. We vary the framework's key parameters, such as the connectivity, the number of switch nodes, the distribution of long- versus short-range connections, and measure the network's relevant communication characteristics. We further explore the robustness against link failures and the ability and efficiency to solve a simple toy problem, the synchronization task. The results confirm that (1) computation in irregular assemblies is a promising and disruptive computing paradigm for self-assembled nano-scale electronics and (2) that 3D small-world interconnect fabrics with a power-law decaying distribution of shortcut lengths are physically plausible and have major advantages over local 2D and 3D regular topologies

Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides

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Broadband integrated beam splitter using spatial adiabatic passage

Light routing and manipulation are important aspects of integrated optics. They essentially rely on beam splitters which are at the heart of interferometric setups and active routing. The most common implementations of beam splitters suffer either from strong dispersive response (directional couplers) or tight fabrication tolerances (multimode interference couplers). In this paper we fabricate a robust and simple broadband integrated beam splitter based on lithium niobate with a splitting ratio achromatic over more than 130 nm. Our architecture is based on spatial adiabatic passage, a technique originally used to transfer entirely an optical beam from a waveguide to another one that has been shown to be remarkably robust against fabrication imperfections and wavelength dispersion. Our device shows a splitting ratio of 0.52$\pm$0.03 and 0.48$\pm$0.03 from 1500\,nm up to 1630\,nm. Furthermore, we show that suitable design enables the splitting in output beams with relative phase 0 or $\pi$. Thanks to their independence to material dispersion, these devices represent simple, elementary components to create achromatic and versatile photonic circuits

Novel Bifunctional Compounds Targeting Nicotine and Dopamine Receptor Subtypes: Synthesis and Pharmacological Investigation

Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson\u2019s disease, schizophrenia and drug addiction or drug dependence, may be substantially built on the existence of intramembrane receptor-receptor interactions within receptor mosaics where it is believed that the D2 receptor may operate as the \u201chub receptor\u201d [1]. In particular, it has been proposed that striatal dopaminergic neurotransmission could be under the control of receptor heteromers containing D2 autoreceptors and non-alpha7 nicotinic acetylcholine heteroreceptors [2]. In an attempt to investigate the biochemical and functional interactions between dopaminergic autoreceptors and nAChRs containing the beta2 subunit, we designed and prepared a group of potential bifunctional derivatives incorporating a D2/D3 agonist moiety and a nicotinic alpha4beta2 antagonist fragment, linked by polymethylene spacers of different length. The new compounds have been biologically characterized for their affinity/specificity/functional profile at the target nACh and D2 receptor subtypes. The synthesis of the designed derivatives and the results of their pharmacological investigation will be presented and discussed. [1] K.Fuxe, D.Marcellino, A.Rivera, Z.Diaz-Cabiale, M.Filip, B.Gago, D.C.S.Roberts, U.Langel, S.Genedani, L.Ferraro, A.de la Calle, J.Narvaez, S.Tanganelli, A.Woods, L.F.Agnati, Brain Res.Rev., 58, 2008, 415-452. [2] D.Quarta, F.Ciruela, K.Patkar, J.Borycz, M.Solinas, C.Lluis, R.Franco, R.A.Wise, S.R.Goldberg, B.T.Hope, A.Woods, S.Ferr\ue9, Neuropsychopharmacol., 32, 2007, 35-42

Polarization entangled photon-pair source based on quantum nonlinear photonics and interferometry

We present a versatile, high-brightness, guided-wave source of polarization entangled photons, emitted at a telecom wavelength. Photon-pairs are generated using an integrated type-0 nonlinear waveguide, and subsequently prepared in a polarization entangled state via a stabilized fiber interferometer. We show that the single photon emission wavelength can be tuned over more than 50 nm, whereas the single photon spectral bandwidth can be chosen at will over more than five orders of magnitude (from 25 MHz to 4 THz). Moreover, by performing entanglement analysis, we demonstrate a high degree of control of the quantum state via the violation of the Bell inequalities by more than 40 standard deviations. This makes this scheme suitable for a wide range of quantum optics experiments, ranging from fundamental research to quantum information applications. We report on details of the setup, as well as on the characterization of all included components, previously outlined in F. Kaiser et al. (2013 Laser Phys. Lett. 10, 045202).Comment: 16 pages, 7 figure

Corrigendum: Effects of a 3-week inpatient multidisciplinary body weight reduction program on body composition and physical capabilities in adolescents and adults with obesity

A correction has been made to Funding. The correct Funding statement is: “Research funded by the Italian Ministry of Health.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated

A quantum relay chip based on telecommunication integrated optics technology

We investigate an integrated optical circuit on lithium niobate designed to implement the teleportation-based quantum relay scheme for one-way quantum communication at a telecom wavelength. Such an advanced quantum circuit merges for the first time, both optical-optical and electro-optical non-linear functions necessary to implement the desired on-chip single qubit teleportation. On one hand, spontaneous parametric down-conversion is used to produce entangled photon-pairs. On the other hand, we take advantage of two photon routers, consisting of electro-optically controllable couplers, to separate the paired photons and to perform a Bell state measurement, respectively. After having validated all the individual functions in the classical regime, we have performed a Hong-Ou-Mandel (HOM) experiment to mimic a one-way quantum communication link. Such a quantum effect, seen as a prerequisite towards achieving teleportation, has been obtained, at one of the routers, when the chip was coupled to an external single photon source. The two-photon interference pattern shows a net visibility of 80%, which validates the proof of principle of a "quantum relay circuit" for qubits carried by telecom photons. In case of optimized losses, such a chip could increase the maximal achievable distance of one-way quantum key distribution links by a factor 1.8. Our approach and results emphasize the high potential of integrated optics on lithium niobate as a key technology for future reconfigurable quantum information manipulation.Comment: 16 pages, 8 figure