Neural network classification of eigenmodes in the magnetohydrodynamic spectroscopy code Legolas

JDJ was supported by funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme, Grant agreement No. 833251 PROMINENT ERC-ADG 2018.A neural network is employed to address a non-binary classification problem of plasma instabilities in astrophysical jets, calculated with the Legolas code. The trained models exhibit reliable performance in the identification of the two instability types supported by these jets. We also discuss the generation of artificial data and refinement of predictions in general eigenfunction classification problems.Peer reviewe

Stochastic macromodeling for hierarchical uncertainty quantification of nonlinear electronic systems

A hierarchical stochastic macromodeling approach is proposed for the efficient variability analysis of complex nonlinear electronic systems. A combination of the Transfer Function Trajectory and Polynomial Chaos methods is used to generate stochastic macromodels. In order to reduce the computational complexity of the model generation when the number of stochastic variables increases, a hierarchical system decomposition is used. Pertinent numerical results validate the proposed methodology

Superspace formulation of general massive gauge theories and geometric interpretation of mass-dependent BRST symmetries

A superspace formulation is proposed for the osp(1,2)-covariant Lagrangian quantization of general massive gauge theories. The superalgebra os0(1,2) is considered as subalgebra of sl(1,2); the latter may be considered as the algebra of generators of the conformal group in a superspace with two anticommuting coordinates. The mass-dependent (anti)BRST symmetries of proper solutions of the quantum master equations in the osp(1,2)-covariant formalism are realized in that superspace as invariance under translations combined with mass-dependent special conformal transformations. The Sp(2) symmetry - in particular the ghost number conservation - and the "new ghost number" conservation are realized as invariance under symplectic rotations and dilatations, respectively. The transformations of the gauge fields - and of the full set of necessarily required (anti)ghost and auxiliary fields - under the superalgebra sl(1,2) are determined both for irreducible and first-stage reducible theories with closed gauge algebra.Comment: 35 pages, AMSTEX, precision of reference

Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy

Distal hereditary motor neuropathies are a rare subgroup of inherited peripheral neuropathies hallmarked by a length-dependent axonal degeneration of lower motor neurons without significant involvement of sensory neurons. We identified patients with heterozygous nonsense mutations in the alpha II-spectrin gene, SPTAN1, in three separate dominant hereditary motor neuropathy families via next-generation sequencing. Variable penetrance was noted for these mutations in two of three families, and phenotype severity differs greatly between patients. The mutant mRNA containing nonsense mutations is broken down by nonsense-mediated decay and leads to reduced protein levels in patient cells. Previously, dominant-negative alpha II-spectrin gene mutations were described as causal in a spectrum of epilepsy phenotypes

Weakness in the ICU: a call to action

Muscle weakness is prevalent in critically ill patients and can have a dramatic effect on short- and long-term outcomes, yet there are currently no interventions with proven efficacy in preventing or treating this complication. In a new randomized trial, researchers found that serial electrical muscle stimulation significantly mitigated ultrasound-defined muscle atrophy, and the treatment was not linked to adverse effects. Although preliminary, these results, together with other recent studies, indicate a paradigm shift to a proactive approach in managing neuromuscular complications in the ICU

Global Anomalies in the Batalin Vilkovisky Quantization

The Batalin Vilkovisky (BV) quantization provides a general procedure for calculating anomalies associated to gauge symmetries. Recent results show that even higher loop order contributions can be calculated by introducing an appropriate regularization-renormalization scheme. However, in its standard form, the BV quantization is not sensible to quantum violations of the classical conservation of Noether currents, the so called global anomalies. We show here that the BV field antifield method can be extended in such a way that the Ward identities involving divergencies of global Abelian currents can be calculated from the generating functional, a result that would not be obtained by just associating constant ghosts to global symmetries. This extension, consisting of trivially gauging the global Abelian symmetries, poses no extra obstruction to the solution of the master equation, as it happens in the case of gauge anomalies. We illustrate the procedure with the axial model and also calculating the Adler Bell Jackiw anomaly.Comment: We emphasized the fact that our procedure only works for the case of Abelian global anomalies. Section 3 was rewritten and some references were added. 12 pages, LATEX. Revised version that will appear in Phys. Rev.

Liver monocytes and kupffer cells remain transcriptionally distinct during chronic viral infection

Due to the scarcity of immunocompetent animal models for chronic viral hepatitis, little is known about the role of the innate intrahepatic immune system during viral replication in the liver. These insights are however fundamental for the understanding of the inappropriate adaptive immune responses during the chronic phase of the infection. We apply the Lymphocytic Choriomenigitis Virus (LCMV) clone 13 mouse model to examine chronic virus-host interactions of Kupffer cells (KC) and infiltrating monocytes (IM) in an infected liver. LCMV infection induced overt cli

Field-enlarging transformations and chiral theories

A field-enlarging transformation in the chiral electrodynamics is performed. This introduces an additional gauge symmetry to the model that is unitary and anomaly-free and allows for comparison of different models discussed in the literature. The problem of superfluous degrees of freedom and their influence on quantization is discussed. Several "mysteries" are explained from this point of view.Comment: 14 pages, LaTeX-file, BI-TP 93/0

BRST quantization of anomalous gauge theories

It is shown how the BRST quantization can be applied to a gauge invariant sector of theories with anomalously broken symmetries. This result is used to show that shifting the anomalies to a classically trivial sector of fields (Wess-Zumino mechanism) makes it possible to quantize the physical sector using a standard BRST procedure, as for a non anomalous theory. The trivial sector plays the role of a topological sector if the system is quantized without shifting the anomalies.Comment: 16 pages, latex, revised and enlarged version to appear in Phys.Rev.