30 research outputs found
HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status
Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease
Particle Acceleration in Pulsar Wind Nebulae: PIC modelling
We discuss the role of particle-in-cell (PIC) simulations in unveiling the
origin of the emitting particles in PWNe. After describing the basics of the
PIC technique, we summarize its implications for the quiescent and the flaring
emission of the Crab Nebula, as a prototype of PWNe. A consensus seems to be
emerging that, in addition to the standard scenario of particle acceleration
via the Fermi process at the termination shock of the pulsar wind, magnetic
reconnection in the wind, at the termination shock and in the Nebula plays a
major role in powering the multi-wavelength signatures of PWNe.Comment: 32 pages, 16 figures, to appear in the book "Modelling Nebulae"
edited by D. Torres for Springer, based on the invited contributions to the
workshop held in Sant Cugat (Barcelona), June 14-17, 201
Image Classification for Age-related Macular Degeneration Screening Using Hierarchical Image Decompositions and Graph Mining
Age-related Macular Degeneration (AMD) is the most common cause of adult blindness in the developed world. This paper describes a new image mining technique to perform automated detection of AMD from color fundus photographs. The technique comprises a novel hierarchical image decomposition mechanism founded on a circular and angular partitioning. The resulting decomposition is then stored in a tree structure to which a weighted frequent sub-tree mining algorithm is applied. The identified sub-graphs are then incorporated into a feature vector representation (one vector per image) to which classification techniques can be applied. The results show that the proposed approach performs both efficiently and accurately
Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-2-hydroxyethyl)-l-glutamine]
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice
Immunopathology of vascular and renal diseases and of organ and celltransplantatio
HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status
Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease
Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma
Experimental cancer immunology and therap