11,161 research outputs found
CoQ10 and Aging.
The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production. Oxidative damage to macromolecules including DNA and electron transport proteins likely increases ROS production resulting in further damage. This oxidative theory of cell aging is supported by the fact that diseases associated with the aging process are marked by increased oxidative stress. Coenzyme Q10 (CoQ10) levels fall with aging in the human but this is not seen in all species or all tissues. It is unknown whether lower CoQ10 levels have a part to play in aging and disease or whether it is an inconsequential cellular response to aging. Despite the current lay public interest in supplementing with CoQ10, there is currently not enough evidence to recommend CoQ10 supplementation as an anti-aging anti-oxidant therapy
Stratigraphy and paleoceanography of a topography-controlled contourite drift in the Pen Duick area, southern Gulf of Cadiz
Chord Label Personalization through Deep Learning of Integrated Harmonic Interval-based Representations
The increasing accuracy of automatic chord estimation systems, the
availability of vast amounts of heterogeneous reference annotations, and
insights from annotator subjectivity research make chord label personalization
increasingly important. Nevertheless, automatic chord estimation systems are
historically exclusively trained and evaluated on a single reference
annotation. We introduce a first approach to automatic chord label
personalization by modeling subjectivity through deep learning of a harmonic
interval-based chord label representation. After integrating these
representations from multiple annotators, we can accurately personalize chord
labels for individual annotators from a single model and the annotators' chord
label vocabulary. Furthermore, we show that chord personalization using
multiple reference annotations outperforms using a single reference annotation.Comment: Proceedings of the First International Conference on Deep Learning
and Music, Anchorage, US, May, 2017 (arXiv:1706.08675v1 [cs.NE]
A Whole Genome Association Study to Detect Loci Associated with Somatic Cell Score in Dairy Cattle
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