23,249 research outputs found
You Tube if you want to – a Web 2.0 approach to staff development in web conferencing
How can we identify and make best use of potential resources in a staff development programme promoting web conferencing? What are the resources we should use? This paper regards web conferencing as a potentially powerful tool at the disposal of an institution intent on exploring new models of blended and online learning appropriate to the changing needs of 21st-century learners. It presents web conferencing in the user-centric context of Web 2.0 – the social web technologies whose educational impact is to empower online communication, collaboration, participation and sharing of resources. Based on findings from an 18-month period of evaluation and initial implementation at Leeds Met, it outlines practical staff development approaches in the related areas of user-created content and community involvement that could promote a more efficient and focused dissemination of the insights and experiences of a local, national and world-wide user group
Predicting kinase inhibitor resistance: Physics-based and data-driven approaches.
Resistance to small molecule drugs often emerges in cancer cells, viruses, and bacteria as a result of the evolutionary pressure exerted by the therapy. Protein mutations that directly impair drug binding are frequently involved in resistance, and the ability to anticipate these mutations would be beneficial in drug development and clinical practice. Here, we evaluate the ability of three distinct computational methods to predict ligand binding affinity changes upon protein mutation for the cancer target Abl kinase. These structure-based approaches rely on first-principle statistical mechanics, mixed physics- and knowledge-based potentials, and machine learning, and were able to estimate binding affinity changes and identify resistant mutations with remarkable accuracy. We expect that these complementary approaches will enable the routine prediction of resistance-causing mutations in a variety of other target proteins
A security architecture for personal networks
Abstract Personal Network (PN) is a new concept utilizing pervasive computing to meet the needs of the user. As PNs edge closer towards reality, security becomes an important concern since any vulnerability in the system will limit its practical use. In this paper we introduce a security architecture designed for PNs. Our aim is to use secure but lightweight mechanisms suitable for resource constrained devices and wireless communication. We support pair-wise keys for secure cluster formation and use group keys for securing intra-cluster communication. In order to analyze the performance of our proposed mechanisms, we carry out simulations using ns-2. The results show that our mechanisms have a low overhead in terms of delay and energy consumption
Electrodeposition of Ni-Si Schottky barriers
Electrodeposition is being used to fabricate magnetic microstructures directly on patterned n-type Si wafers of various substrate resistivities. The Ni-Si Schottky barrier is characterized and found to be of high quality for relatively low Si resistivities (1-2 Omega(.)cm), with extremely low reverse leakage. It is shown that a direct correlation exists among the electrodeposition potential, the roughness, and the coercivity of the films. A conductive seed layer or a back contact is not compulsory for electrodeposition on Si with resistivities up to 15 Omega(.)cm. This shows that electrodeposition of magnetic materials on Si might be a viable fabrication technique for magnetoresistance and spintronics applications
Angular dependence of core hole screening in LiCoO2: A DFT+U calculation of the oxygen and cobalt K-edge x-ray absorption spectra
Angular dependent core-hole screening effects have been found in the cobalt
K-edge x-ray absorption spectrum of LiCoO2, using high-resolution data and
parameter-free GGA+U calculations. The Co 1s core-hole on the absorber causes
strong local attraction. The core-hole screening on the nearest neighbours
cobalt induces a 2 eV shift in the density of states with respect to the
on-site 1s-3d transitions, as detected in the Co K pre-edge spectrum. Our DFT+U
calculations reveal that the off-site screening is different in the
out-of-plane direction, where a 3 eV shift is visible in both calculations and
experiment. The detailed analysis of the inclusion of the core-hole potential
and the Hubbard parameter U shows that the core-hole is essential for the
off-site screening, while U improves the description of the angular dependent
screening effects. In the case of oxygen K-edge, both the core-hole potential
and the Hubbard parameter improve the relative positions of the spectral
features
A fast ethanol assay to detect seed deterioration
The most common way to test seed quality is to use a simple and reliable but time- and space-consuming germination test. In this paper we present a fast and simple method to analyse cabbage seed deterioration by measuring ethanol production from partially imbibed seeds. The method uses a modified breath analyser and is simple compared to gas chromatographic or enzymatic procedures. A modified method using elevated temperatures (40°C instead of 20°C) shortened the assay time and improved its sensitivity. The analysis showed an inverse correlation between ethanol production and seed quality (e.g. the final percentages or speed of germination and the number of normal seedlings). The increase in ethanol production was observed when cabbage seeds were deteriorated by storage under ambient conditions or hot water treatments, both of which reduced the number of normal seedlings. Premature seeds produced more ethanol upon imbibition than mature seeds. Ethanol production occurred simultaneously with oxygen consumption, indicating that lack of oxygen is not the major trigger for ethanol production
Theory of Resonant Inelastic X-ray Scattering by Collective Magnetic Excitations
I present a tractable theory for the Resonant Inelastic X-ray Scattering
(RIXS) spectral function of magnons. The low-energy transition operator is
written as a product of local spin operators times fundamental x-ray absorption
spectra. This leads to simple selection rules for the magnetic cross section.
The scattering cross section linear (quadratic) in spin operators is
proportional to the magnetic circular (linear) dichroic absorption. RIXS is a
novel tool to measure magnetic quasi particles (magnons) and the incoherent
spectral weight, as well as multiple magnons up to very high energy losses, in
small samples, thin films and multilayers, complementary to Neutron scattering
Atomistic models of hydrogenated amorphous silicon nitride from first principles
We present a theoretical study of hydrogenated amorphous silicon nitride (a-SiNx:H), with equal concentrations of Si and N atoms (x=1), for two considerably different densities (2.0 and 3.0 g/cm3). Densities and hydrogen concentration were chosen according to experimental data. Using first-principles molecular-dynamics within density-functional theory the models were generated by cooling from the liquid. Where both models have a short-range order resembling that of crystalline Si3N4 because of their different densities and hydrogen concentrations they show marked differences at longer length scales. The low-density nitride forms a percolating network of voids with the internal surfaces passivated by hydrogen. Although some voids are still present for the high-density nitride, this material has a much denser and uniform space filling. The structure factors reveal some tendency for the nonstoichiometric high-density nitride to phase separate into nitrogen rich and poor areas. For our slowest cooling rate (0.023 K/fs) we obtain models with a modest number of defect states, where the low (high) density nitride favors undercoordinated (overcoordinated) defects. Analysis of the structural defects and electronic density of states shows that there is no direct one-to-one correspondence between the structural defects and states in the gap. There are several structural defects that do not contribute to in-gap states and there are in-gap states that do only have little to no contributions from (atoms in) structural defects. Finally an estimation of the size and cooling rate effects on the amorphous network is reported.
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